2-Aethyl-4-methylacetophenon | 58632-87-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Aethyl-4-methylacetophenon
• 英文别名: 2-ethyl-4-methylacetophenone；2'-Ethyl-4'-methylacetophenone；1-(2-ethyl-4-methylphenyl)ethanone
• CAS: 58632-87-4
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: IUFUODFAIFHGCU-UHFFFAOYSA-N

物化性质

• 沸点：
  255.6±19.0 °C(Predicted)
• 密度：
  0.953±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-乙基甲苯 、 乙酰氯 在 三氯化铝 作用下， 以 二氯甲烷 为溶剂， 生成 2-Aethyl-4-methylacetophenon 、 1-(4-ethyl-2-methyl-phenyl)-ethanone
  参考文献：
  名称：

  Tetralin formate ester aroma chemicals

  摘要：

  本发明涉及具有芳香麝香般气味的新型甲酸酯四氢萘化合物。

  公开号：

  US05292719A1

文献信息

• LIGHT-DRIVEN ROTARY MOLECULAR MOTORS
  申请人：Bell Thomas W.

  公开号：US20110077394A1

  公开（公告）日：2011-03-31

  Compounds of Formula (1) are disclosed. C b is a carbocyclic or heterocyclic group having an atom within the cyclic structure selected from C, N, Si, and C r and singly bound to A. A is CR, COR, CSR, CNR 2 , CCN, CCONR 2 , CNO 2 , CNNAr, CX′, or N. C r is a chromophore having a substantially planar cyclic structure. The compounds function as nanometer-scale rotary molecular motors powered and controlled by light energy. The design of the molecular motor devices is flexible so that the rotary direction, drive light wavelength, and other physical characteristics can be varied. The compounds can be chemically functionalized to allow it to be integrated into or attached to a variety of structures. The device can be used in applications where mechanical power, positional control, and information encoding are to be generated at the size scale of individual molecules.

  式（1）的化合物已被披露。 C b 是一个具有环结构内选自C、N、Si和C r 的原子的碳环或杂环基团，并与A单键相连。A是CR、COR、CSR、CNR 2 、CCN、CCONR 2 、CNO 2 、CNNAr、CX′或N。C r 是具有基本平面环结构的色团。这些化合物作为受光能驱动和控制的纳米尺度旋转分子马达。分子马达装置的设计灵活，使得旋转方向、驱动光波长和其他物理特性可以变化。这些化合物可以在化学上官能化，以使其能够集成到或附着到各种结构中。该装置可用于需要在单个分子尺度上产生机械动力、位置控制和信息编码的应用中。
• Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
  申请人：Arvinas, Inc.

  公开号：US10647698B2

  公开（公告）日：2020-05-12

  The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, Inhibitors of Apoptosis Proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作雌激素受体（靶蛋白）的调节剂。特别是，本公开涉及双功能化合物，其一端含有 Von Hippel-Lindau 配体、cereblon 配体、凋亡蛋白抑制剂配体、小鼠双敏同源物 2 配体或其组合中的至少一种、其一端与相应的 E3 泛素连接酶结合，另一端与靶蛋白结合，从而将靶蛋白置于泛素连接酶附近，以实现对靶蛋白的降解（和抑制）。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防因目标蛋白聚集或积聚而导致的疾病或失调。
• Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
  申请人：WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.

  公开号：US11021457B2

  公开（公告）日：2021-06-01

  The present invention provides an isoindolone-imide ring-1,3-dione-2-ene compound, and a preparation method, a pharmaceutical composition and use thereof. Specifically, the present invention provides a compound of Formula (I) below or a pharmaceutically acceptable salt thereof, wherein Ar is an isoindolinone-imide group represented by Formula (II), L is absent or is a divalent, trivalent or tetravalent linking group, and X is a group represented by Formula (III). Definitions of the other groups are as described in the specification. The compound of Formula (I) is an autophagy modulators, particularly a mammalian ATG8 homolog modulator.

  本发明提供了一种异吲哚酮-亚胺环-1,3-二酮-2-烯化合物及其制备方法、药物组合物和用途。具体地说，本发明提供了下式（I）化合物或其药学上可接受的盐，其中 Ar 是由式（II）代表的异吲哚啉酮亚胺基团，L 不存在或为二价、三价或四价连接基团，X 是由式（III）代表的基团。其他基团的定义如说明书所述。式（I）化合物是一种自噬调节剂，特别是哺乳动物 ATG8 同源物调节剂。
• Ruthenium-Catalysed Murai-Type Couplings at Room Temperature
  作者：Stefan Busch、Walter Leitner

  DOI：10.1002/1615-4169(20010226)343:2<192::aid-adsc192>3.0.co;2-s

  日期：2001.2.26
• TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE
  申请人：Arvinas Operations, Inc.

  公开号：US20210145832A1

  公开（公告）日：2021-05-20

  The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) TBK1. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds TBK1 such that TBK1 is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of TBK1. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of TBK1.