(2S,3R)-(+)-3-methylpentan-2-ol | 205698-03-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R)-(+)-3-methylpentan-2-ol
• 英文别名: (2S,3R)-e-3-Methyl-2-pentanol；3-Methyl-2-pentanol；(2S)-3-methylpentan-2-ol
• CAS: 205698-03-9
• 化学式: C₆H₁₄O
• 分子量: 102.177
• InChiKey: ZXNBBWHRUSXUFZ-GDVGLLTNSA-N

物化性质

• 沸点：
  133.5±8.0 °C(Predicted)
• 密度：
  0.811±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基-2-戊酮 在 mercaptoethyl alcohol 、 Tris-HCl buffer 、 alcohol dehydrogenase from Thermoanaerobium brockii 、 烟酰胺腺嘌呤双核苷酸磷酸盐 、 异丙醇 作用下， 生成 (2S,3S)-3-Methyl-2-pentanol 、 (2S,3R)-(+)-3-methylpentan-2-ol 、 (2R,3R)-3-methylpentan-2-ol 、 (2R,3S)-3-Methyl-2-pentanol
  参考文献：
  名称：

  Thermostable enzymes in organic synthesis. 2. Asymmetric reduction of ketones with alcohol dehydrogenase from Thermoanaerobium brockii

  摘要：

  DOI：

  10.1021/ja00261a026

文献信息

• Hardening composition
  申请人：Dentsply DeTrey GmbH

  公开号：EP2070507A1

  公开（公告）日：2009-06-17

  A hardening composition comprising a particulate glass, said glass comprising 10-35% by weight of silica, 10-35% by weight of alumina, 3-30% by weight of zinc oxide, 4-30% by weight of P2O5 and 3-25% by weight of fluoride, and an acidic copolymer reactive with the particulate glass under aqueous conditions. An aqueous polymer solution comprising 10 to 65% by weight of the acidic copolymer of the hardening composition with a mean molecular weight of from 50,000 to 200,000, obtainable by a process comprising the copolymerization of a mixture containing acrylic acid and an acrylic acid ester (I) and / or a compound of the formula (II) and, optionally, a compound of the formula (III): wherein k is an integer of from 1 to 5; h is an integer from 0 to (5 - k); n is an integer of from 1 to 3; R1 is hydrogen or a C1-6 alkyl group, and; R2 and R3 independently represent hydrogen, a C1-6 alkyl group or a moiety of the following formula (IV): wherein m independently is an integer of from 0 to 3, and L is -CH2- or -CH=CH-; provided that at least one of R1, R2 or R3 is not hydrogen.

  一种硬化组合物，包括微粒玻璃，所述玻璃包括 10-35%（重量）的二氧化硅、 10-35%（重量）的氧化铝、3-30%（重量）的氧化锌、4-30%（重量）的 P2O5 和 3-25%（重量）的氟化物，以及在水性条件下与微粒玻璃反应的酸性共聚物。一种聚合物水溶液，包含 10-65%（重量）的硬化组合物的酸性共聚物，其平均分子量为 50,000 至 200,000，可通过共聚含有丙烯酸和丙烯酸酯（I）和/或式（II）化合物以及可选式（III）化合物的混合物的工艺获得： 其中 k 是 1 至 5 的整数；h 是 0 至 (5 - k) 的整数；n 是 1 至 3 的整数；R1 是氢或 C1-6 烷基；R2 和 R3 分别代表氢、C1-6 烷基或下式 (IV) 的分子： 其中 m 独立地为 0 至 3 的整数，L 为-CH2-或-CH=CH-；条件是 R1、R2 或 R3 中至少有一个不是氢。
• Kirmse, Wolfgang; Guenther, Bernd-Rainer; Knist, Johannes, Chemische Berichte, 1980, vol. 113, # 6, p. 2127 - 2139
  作者：Kirmse, Wolfgang、Guenther, Bernd-Rainer、Knist, Johannes、Kratz, Sigrid、Loosen, Karin、et al.

  DOI：——

  日期：——
• AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：Sugen, Inc.

  公开号：EP1603570B1

  公开（公告）日：2013-01-23
• Novel Saperconazole Crystalline Forms and Related Processes, Pharmaceutical Compositions and Methods
  申请人：Scoppettuolo Lisa

  公开号：US20070293674A1

  公开（公告）日：2007-12-20

  The invention provides novel soluble conazole crystalline forms (e.g., cisitraconazole, saperconazole) that include salts, co-crystals and polymorphs useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.
• HARDENING COMPOSITION
  申请人：BLACKWELL GORDON

  公开号：US20110071233A1

  公开（公告）日：2011-03-24

  A hardening composition comprising a particulate glass, said glass comprising 10-35% by weight of silica, 10-35% by weight of alumina, 3-30% by weight of zinc oxide, 4-30% by weight of P 2 O 5 and 3-25% by weight of fluoride, and an acidic copolymer reactive with the particulate glass under aqueous conditions. An aqueous polymer solution comprising 10 to 65% by weight of the acidic copolymer of the hardening composition with a mean molecular weight of from 50,000 to 200,000, obtainable by a process comprising the copolymerization of a mixture containing acrylic acid and an acrylic acid ester (I) and/or a compound of the formula (II) and, optionally, a compound of the formula (III): wherein k is an integer of from 1 to 5; h is an integer from 0 to (5-k); n is an integer of from 1 to 3; R1 is hydrogen or a C1-6 alkyl group, and; R2 and R3 independently represent hydrogen, a C1-6 alkyl group or a moiety of the following formula (IV): wherein m independently is an integer of from 0 to 3, and L is —CH 2 — or —CH═CH—; provided that at least one of R1, R2 or R3 is not hydrogen.