mercaptoethyl alcohol | 129976-27-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: mercaptoethyl alcohol
• 英文别名: beta-hydroxyethylmercaptan；1-hydroxyethanethiol；1-mercaptoethanol；mercaptoethanol；hydroxyethanethiol；2-ethanol-1-thiol；Mercapto-ethanol；1-sulfanylethanol
• CAS: 129976-27-8
• 化学式: C₂H₆OS
• 分子量: 78.135
• InChiKey: GHKCSRZBNZQHKW-UHFFFAOYSA-N

物化性质

• 沸点：
  126.2±23.0 °C(Predicted)
• 密度：
  1.063±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  mercaptoethyl alcohol 、 2-氯乙醛缩二甲醇 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 15.0h， 生成 (2-hydroxyethylthio)acetaldehyde dimethyl acetal
  参考文献：
  名称：

  (Meth)acrylate derivative, intermediate thereof, and polymer compound

  摘要：

  提供一种聚合物化合物，如下所示，可用作具有较少膨胀的聚合物的原材料，通过聚合含有上述聚合物化合物的原材料得到的聚合物，包含上述聚合物并在LWR方面改进的光阻组合物，以及上述聚合物化合物的高效生产工艺：其中n表示0到2的整数；R1表示氢原子、甲基或三氟甲基；R2、R3、R4、R5、R6、R7、R8、R9和R10表示氢原子、具有1到6个碳原子的烷基或类似物；W表示具有1到10个碳原子的烷基或类似物；Y1和Y2表示氧原子或硫原子。

  公开号：

  US08492562B2
• 作为试剂：
  描述：

  6-氨基-2-(乙基硫代)-1H-嘧啶-4-酮 在 盐酸 、 sodium dithionite 、 mercaptoethyl alcohol 、 氧气 、 对甲苯磺酸 、 溶剂黄146 、 sodium nitrite 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 25.0h， 生成 2-ethylthio-6-(D-erythro-3-hydroxy-1,2-O-isopropylidenepropyl)pteridin-4(3H)-one
  参考文献：
  名称：

  Synthesis of 2-Ethylthio-6-(3-hydroxy- 1,2-O-isopropylidenepropyl)pteridin- 4(3H)-one

  摘要：

  A strategy has been described for the synthesis of 2-ethylthio-6-(3-hydroxy-1,2-O-isopropylidenepropyl)pteridin-4(3H)-one, which can be used as a useful intermediate for the conversion of neopterin to biopterin.

  DOI：

  10.3987/com-00-8881

文献信息

• [EN] AMINO QUINAZOLINES AS KINASE INHIBITORS<br/>[FR] AMINO-QUINAZOLINES EN TANT QU'INHIBITEURS DE KINASE
  申请人：GLAXO GROUP LTD

  公开号：WO2013025958A1

  公开（公告）日：2013-02-21

  Disclosed are compounds having the formula (Formula (I)): wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

  揭示了具有以下公式（公式（I））的化合物：其中R1、R2、R3和Z如本文所定义，并且制备和使用这些化合物的方法。
• Nitrosated and nitrosylated &agr;-adrenergic receptor antagonist, compositions and methods of use
  申请人：NitroMed, Inc.

  公开号：US06469065B1

  公开（公告）日：2002-10-22

  The present invention describes novel nitrosated and/or nitrosylated &agr;-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated &agr;-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one &agr;-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

  本发明描述了新型的硝化和/或亚硝化α-肾上腺素受体拮抗剂，以及含有至少一种硝化和/或亚硝化α-肾上腺素受体拮抗剂的新型组合物，可选地，含有一种或多种捐赠、转移或释放一氧化氮、提高内源性内皮衍生舒张因子水平、刺激内源性一氧化氮合成或是一氧化氮合酶底物的化合物，和/或一种或多种血管活性剂。本发明还提供了含有至少一种α-肾上腺素受体拮抗剂和一种或多种捐赠、转移或释放一氧化氮、提高内源性内皮衍生舒张因子水平、刺激内源性一氧化氮合成或是一氧化氮合酶底物和/或一种或多种血管活性剂的新型组合物。本发明还提供了治疗或预防男性和女性性功能障碍、增强男性和女性性反应、治疗或预防良性前列腺增生、高血压、充血性心力衰竭、变异（Printzmetal）心绞痛、青光眼、神经退行性疾病、血管痉挛性疾病、认知障碍、急迫性尿失禁或过度活跃膀胱，并逆转麻醉状态的方法。
• Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
  申请人：——

  公开号：US20020143007A1

  公开（公告）日：2002-10-03

  The present invention describes novel nitrosated and/or nitrosylated &agr;-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated &agr;-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one &agr;-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

  本发明描述了新型硝化和/或硝基化α-肾上腺素受体拮抗剂，以及包含至少一种硝化和/或硝基化α-肾上腺素受体拮抗剂的新型组合物，以及可选地包含一种或多种捐赠、转移或释放一氧化氮、提高内源性内皮衍生松弛因子水平、刺激内源性一氧化氮合成或是一氧化氮合成酶底物的化合物，和/或一种或多种血管活性药物。本发明还提供了包含至少一种α-肾上腺素受体拮抗剂和一种或多种捐赠、转移或释放一氧化氮、提高内源性内皮衍生松弛因子水平、刺激内源性一氧化氮合成或是一氧化氮合成酶底物，和/或一种或多种血管活性药物的新型组合物。本发明还提供了用于治疗或预防男性和女性的性功能障碍、增强男性和女性的性反应，以及治疗或预防良性前列腺增生、高血压、充血性心力衰竭、变异性（Printzmetal）心绞痛、青光眼、神经退行性疾病、血管痉挛性疾病、认知障碍、急迫性尿失禁或过度活跃膀胱，以及逆转麻醉状态的方法。
• Nucleosides having bicyclic sugar moiety
  申请人：ICN Pharmaceuticals, Inc.

  公开号：US06403566B1

  公开（公告）日：2002-06-11

  Conformationally restricted 2′, 4′—bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2′ and C4′ of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients. Oligonucleotides composed of these novel nucleosides are useful for oligonucleotide therapeutic and diagnostic compounds.

  本文描述了构象受限的2′，4′-桥联核苷类似物。这些化合物可以通过在核苷的C2′和C4′处通过连接物或连接分子的环化来制备。这些新型核苷具有理想的锁定糖环形，并且可能作为药用成分。由这些新型核苷组成的寡核苷酸对寡核苷酸治疗和诊断化合物非常有用。
• Sulfur-containing nitroaminobenzene dyes, process and hair dye
  申请人：Clairol Incorporated

  公开号：US04799934A1

  公开（公告）日：1989-01-24

  Novel sulfur containing nitroamino benzene dyes of formula: ##STR1## and salts thereof wherein (a) R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of alkyl, hydroxyalkyl, polyhydroxyalky, aminoalkyl, monoalkylamioalkyl and dialkylaminoalkyl, wherein (b) n is 0, 1 or 2, and wherein (c) the group ##STR2## occupies a position that is meta or para to the group-NHR.sub.1 ; a process for synthesizing these compounds and their use as direct dyeing hair dyes are being disclosed.

  新型含硫的硝基氨基苯染料的化学式：##STR1##及其盐，其中(a) R.sub.1和R.sub.2相同或不同，选自烷基、羟基烷基、多羟基烷基、氨基烷基、单烷基氨基烷基和二烷基氨基烷基组成的群，其中(b) n为0、1或2，且(c)基团##STR2##占据一个与基团-NHR.sub.1的间位或对位的位置；揭示了合成这些化合物的过程以及它们作为直接染发剂的用途。