2-[2-[2-(2-羟基乙氧基)乙基硫烷基]乙氧基]乙醇 | 64036-00-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-[2-[2-(2-羟基乙氧基)乙基硫烷基]乙氧基]乙醇
• 英文名称: 6-Thia-3,9-dioxa-1,11-undecanediol
• 英文别名: 2,2'-(3-thia-pentane-1,5-diyldioxy)-bis-ethanol；3,9-dioxa-6-thia-undecane-1,11-diol；bis-[2-(2-hydroxy-ethoxy)-ethyl]-sulfide；2.2'-Bis-(2-hydroxy-aethoxy)-diaethylsulfid；Bis-[2-(2-hydroxy-aethoxy)-aethyl]-sulfid；1,4,10,13-Tetraoxa-7-thiatridecan；2,2'-{Sulfanediylbis[(ethane-2,1-diyl)oxy]}di(ethan-1-ol)；2-[2-[2-(2-hydroxyethoxy)ethylsulfanyl]ethoxy]ethanol
• CAS: 64036-00-6
• 化学式: C₈H₁₈O₄S
• 分子量: 210.295
• InChiKey: KWHMEFJLTCULBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[2-[2-(2-羟基乙氧基)乙基硫烷基]乙氧基]乙醇 在 氯化亚砜 、 氯仿 、 sodium ethanolate 作用下， 生成 6,12,18,24-tetraoxa-3,9,15,21,27-pentathia-nonacosane-1,29-diol
  参考文献：
  名称：

  Policy analysis in the presence of distorting taxes

  摘要：

  This article first describes the new literature in environmental economics on the so-called "double-dividend" and then explores its implications for a broad range of economic issues. This literature reveals that in a second-best, general-equilibrium setting environmental measures raise costs and prices and thereby reduce the real wage. This rise in the cost of living reduces slightly the quantity of labor supplied in an already highly distorted labor market, giving rise to losses in social welfare that can be large relative to the basic gains from a cleaner environment. These losses can be offset to some extent by using revenues (if any) from the environmental programs to reduce existing taxes on labor This same line of analysis applies to many programs and institutions in the economy that mise the cost of living: tariffs and quotas on imports, agricultural price-support programs, monopoly pricing, programs of occupational licensure that limit entry, and many others. Thus, traditional, partial-equilibrium benefit-cost analysis appears, in many instances, to have unwittingly omitted from the calculations a potentially quite significant class of social costs. (C) 2000 by the Association for Public Policy and Management.

  DOI：

  10.1002/1520-6688(200023)19:4<603::aid-pam5>3.0.co;2-3
• 作为产物：
  描述：

  2-氯乙氧基乙醇 在 硫化氢 、 sodium ethanolate 作用下， 生成 2-巯基乙氧基乙醇 、 2-[2-[2-(2-羟基乙氧基)乙基硫烷基]乙氧基]乙醇
  参考文献：
  名称：

  Policy analysis in the presence of distorting taxes

  摘要：

  This article first describes the new literature in environmental economics on the so-called "double-dividend" and then explores its implications for a broad range of economic issues. This literature reveals that in a second-best, general-equilibrium setting environmental measures raise costs and prices and thereby reduce the real wage. This rise in the cost of living reduces slightly the quantity of labor supplied in an already highly distorted labor market, giving rise to losses in social welfare that can be large relative to the basic gains from a cleaner environment. These losses can be offset to some extent by using revenues (if any) from the environmental programs to reduce existing taxes on labor This same line of analysis applies to many programs and institutions in the economy that mise the cost of living: tariffs and quotas on imports, agricultural price-support programs, monopoly pricing, programs of occupational licensure that limit entry, and many others. Thus, traditional, partial-equilibrium benefit-cost analysis appears, in many instances, to have unwittingly omitted from the calculations a potentially quite significant class of social costs. (C) 2000 by the Association for Public Policy and Management.

  DOI：

  10.1002/1520-6688(200023)19:4<603::aid-pam5>3.0.co;2-3

文献信息

• Synthesis and metal transport ability of a new series of thiamacrocycles containing thiol and disulfide groups inside the ring
  作者：Tatsuya Nabeshima、Taizo Aoki、Tsutomu Haruyama、Toshinobu Shinnai、Hideaki Ohshiro、Toshiyuki Saiki、Yumihiko Yano

  DOI：10.1002/hc.1044

  日期：——

  methods for thiamacrocycles containing two thiol groups or a disulfide linkage and their abilities to effect single heavy-metal-ion transport across a liquid membrane were examined. High Ag+ selectivity was accomplished by the thiol or disulfide hosts, although all the corresponding crown ether analogs bearing a disulfide group showed no Ag+ selectivity. The difference of the transport preferences

  检查了含有两个硫醇基团或二硫键的硫大环的合成方法及其影响单个重金属离子跨液膜传输的能力。硫醇或二硫化物主体实现了高 Ag+ 选择性，尽管所有带有二硫化物基团的相应冠醚类似物都没有显示出 Ag+ 选择性。此处制备的噻冠醚之间传输偏好的差异被认为是由连接到 Ag+ 的硫原子的位置和数量以及主体的腔尺寸反映的。© 2001 John Wiley & Sons, Inc. 杂原子化学 12:276–281, 2001
• Photographic element containing a cyclic thioether compound
  申请人：Eastman Kodak Company

  公开号：US04752560A1

  公开（公告）日：1988-06-21

  This invention is directed to a photographic element containing a radiation-sensitive silver halide emulsion layer and a cyclic thioether compound comprised of at least one oxygen atom and at least three sulfur atoms, each of said atoms being separated from one another by a divalent alkylene group.

  本发明涉及一种包含辐射敏感的银卤化物乳液层和环状硫醚化合物的摄影元素，所述环状硫醚化合物由至少一个氧原子和至少三个硫原子组成，每个原子之间由双价烷基组分隔。
• Quantifying macrocyclization-induced strain utilizing <i>N</i>-phenylimides as conformational reporters
  作者：Bright U. Emenike、David W. Shinn、Ronald A. Spinelle、Barney Yoo、Ambar M. Rosario

  DOI：10.1039/d3cc06296a

  日期：——

  Incorporating an N-phenylimide unit into macrocycles enabled measurements of macrocyclization strains by comparing the N-phenylimide's conformational changes to similar units attached to a linear-chain control.

  将 N-苯基亚胺单元加入大环中，通过比较 N-苯基亚胺与线性链对照组中类似单元的构象变化，可以测量大环化应变。
• Photographic elements and compositions containing cyclic thioethers
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0216973A1

  公开（公告）日：1987-04-08

  Cyclic thioether comprising at least three sulfur atoms and at least one oxygen atom, each sulfur or oxygen atom being separated from another sulfur or oxygen atom by a polymethylene group. Application to photography, in particular as sensitizer and/or development accelerator. Fig. 1 shows a photographic film in which the thioether performs the function of a development accelerator.

  环状硫醚，由至少三个硫原子和至少一个氧原子组成，每个硫原子或氧原子与另一个硫原子或氧原子之间由一个聚甲醛基团隔开。 应用于摄影，特别是作为感光剂和/或显影促进剂。图 1 显示了一种照相胶片，其中的硫醚具有显影促进剂的功能。
• DERIVATIVES OF SMALL INTERFERING RNAS AND USE THEREOF
  申请人：Consejo Superior De Investigaciones Científicas (CSIC)

  公开号：EP2636678A1

  公开（公告）日：2013-09-11

  The present invention relates to a small interfering RNA (siRNA) being 2'-O-methyl modified and there being attached thereto by a phosphodiester bond a position 3', wherein group R in position 3', wherein R is selected from among: a C1-C6 alkyl substituted with at least one -OH group; a C4-C6 cycloalkyl substituted with at least one -OH group; a C4-C6 heterocycloalkyl; a heteroalkyl chain having between 2 and 7 atoms, wherein at least one is an oxygen atom or a sulphur atom, the chain preferably being substituted with at least one -OH group; and a heteroaryl the ring whereof being formed of between 3 and 6 atoms and at least one of said atoms is an oxygen atom. The present invention furthermore refers to the use of said siRNA for the treatment of inflammatory diseases, preferably inflammatory bowel disease.

  本发明涉及一种经 2'-O-甲基修饰的小干扰 RNA（siRNA），其 3'位通过磷酸二酯键相连，其中 3'位的基团 R 选自以下基团被至少一个-OH 基团取代的 C1-C6 烷基；被至少一个-OH 基团取代的 C4-C6 环烷基；C4-C6 杂环烷基；具有 2 至 7 个原子的杂烷基链，其中至少一个是氧原子或硫原子，该链最好被至少一个-OH 基团取代；以及杂芳基，其环由 3 至 6 个原子组成，其中至少一个原子是氧原子。本发明还涉及将所述 siRNA 用于治疗炎症性疾病，最好是炎症性肠病。