(E)-2-fluoro-1-phenyl-2-(phenylsulfonyl)-5-p-tolylpent-4-en-1-one | 1203825-79-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-2-fluoro-1-phenyl-2-(phenylsulfonyl)-5-p-tolylpent-4-en-1-one
• 英文别名: (E)-2-(benzenesulfonyl)-2-fluoro-5-(4-methylphenyl)-1-phenylpent-4-en-1-one
• CAS: 1203825-79-9
• 化学式: C₂₄H₂₁FO₃S
• 分子量: 408.493
• InChiKey: VOWRRUPMYVSGBZ-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-甲基-4-丙-1-炔基苯 、 2-fluoro-1-phenyl-2-(phenylsulfonyl)ethanone 在 四(三苯基膦)钯 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以92%的产率得到(E)-2-fluoro-1-phenyl-2-(phenylsulfonyl)-5-p-tolylpent-4-en-1-one
  参考文献：
  名称：

  Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles

  摘要：

  A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different alpha-substituted fluoro(phenyisulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.126

文献信息

• Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles
  作者：Chuanfa Ni、Jinbo Hu

  DOI：10.1016/j.tetlet.2009.09.126

  日期：2009.12

  A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different alpha-substituted fluoro(phenyisulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers. (C) 2009 Elsevier Ltd. All rights reserved.