5-(4-acetylphenyl)thiophene-2-carbaldehyde | 886509-28-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(4-acetylphenyl)thiophene-2-carbaldehyde
• 英文别名: 5-(4-Acetyl-phenyl)-thiophene-2-carbaldehyde
• CAS: 886509-28-0
• 化学式: C₁₃H₁₀O₂S
• 分子量: 230.287
• InChiKey: VOZUIYZQWNJMHE-UHFFFAOYSA-N

物化性质

• 沸点：
  400.1±35.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  62.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-硫代乙内酰脲 、 5-(4-acetylphenyl)thiophene-2-carbaldehyde 在 溶剂黄146 、 β-丙氨酸 作用下， 反应 15.0h， 以79%的产率得到5-((5-(4-acetylphenyl)thiophen-2-yl)methylene)-2-thioxoimidazolidin-4-one
  参考文献：
  名称：

  Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

  摘要：

  A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perform. Structure activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed 2-thioxoimidazolidin-4-one/thiophene core. The ability of the resulting compounds to inhibit the lytic activity of both isolated perform protein and perforin delivered in situ by natural killer cells was determined. A number of compounds showed excellent activity at concentrations that were nontoxic to the killer cells, and several were a significant improvement on previous classes of inhibitors, being substantially more potent and soluble. Representative examples showed rapid and reversible binding to immobilized mouse perforin at low concentrations (<= 2.5 mu M) by surface plasmon resonance and prevented formation of perforin pores in target cells despite effective target cell engagement, as determined by calcium influx studies. Mouse PK studies of two analogues showed T-1/2 values of 1.1-1.2 h (dose of 5 mg/kg iv) and MTDs of 60-80 mg/kg (ip).

  DOI：

  10.1021/jm401604x
• 作为产物：
  描述：

  5-溴噻吩-2-甲醛 、 钾(4-乙酰基苯基)(三氟)硼酸酯(1-) 在 {2,6-bis[(di-1-piperidinylphosphino)amino]phenyl}palladium(II) chloride 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 、 正丁醇 为溶剂， 反应 7.0h， 以85%的产率得到5-(4-acetylphenyl)thiophene-2-carbaldehyde
  参考文献：
  名称：

  1,3-二氨基苯衍生的氨基膦钯夹钳络合物{C6H3 [NHP（哌啶基）2] 2Pd（Cl）} –活性优异的铃木-宫浦催化剂，具有出色的官能团耐受性

  摘要：

  快速制备的1,3-二氨基苯衍生的氨基膦钳形配合物{C 6 H 3 [NHP（哌啶基）2 ] 2 Pd（Cl）}（1）是一种有效的Suzuki催化剂，具有出色的官能团耐受性。仅很少检测到副产物形成，例如均偶联，去溴化或原去硼，如果这样，在所有情况下均低于5％的水平。提出的反应方案是普遍适用的。实验观察表明，钯纳米颗粒的催化活性形式1。

  DOI：

  10.1002/adsc.200900848

文献信息

• [EN] COMPOUNDS, PREPARATIONS AND USES THEREOF<br/>[FR] COMPOSÉS, LEURS PRÉPARATIONS ET LEURS UTILISATIONS
  申请人：PETER MACCALLUM CANCER INST

  公开号：WO2011075784A1

  公开（公告）日：2011-06-30

  The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susceptible to a disease or disorder, or having a disease or disorder associated with undesirable perforin activity.

  本发明提供了式（I）的新化合物，包括这些化合物的药物组合物以及使用这些化合物作为抑制穿孔素活性的药剂或药物，用于治疗患有与不良穿孔素活性相关的疾病或紊乱、或处于患有风险或易感染某种疾病或紊乱的受试者的方法。
• COMPOUNDS, PREPARATION AND USES THEREOF
  申请人：Spicer Julie Ann

  公开号：US20130065897A1

  公开（公告）日：2013-03-14

  The present invention provides novel compounds of the Formula I, pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susceptible to a disease or disorder, or having a disease or disorder associated with undesirable perforin activity.

  本发明提供了公式I的新化合物，包括这些化合物的制药组合物以及使用这些化合物作为抑制穿孔素活性的药剂或药物的方法，以及用于治疗处于风险或易感疾病或紊乱，或具有与不良穿孔素活性相关的疾病或紊乱的受试者。
• Synthesis of palladium complexes containing benzimidazole core and their catalytic activities in direct arylation of heteroaromatic species
  作者：Sema Şeker、Öznur Doğan Ulu、Nevın Gürbüz、Namık Özdemır、İsmaıl Özdemır、Hakan Bülbül

  DOI：10.1080/00958972.2024.2335629

  日期：——

  Herein, we report the synthesis of four new palladium complexes containing a benzimidazole core and examine their catalytic activities in the direct arylation of heteroaromatic species with aryl br...

  在此，我们报告了四种含有苯并咪唑核心的新型钯配合物的合成，并检查了它们在杂芳族物质与芳基溴的直接芳基化中的催化活性。
• COMPOUNDS, PREPARATIONS AND USES THEREOF
  申请人：Peter MacCallum Cancer Institute

  公开号：EP2515903A1

  公开（公告）日：2012-10-31
• Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin
  作者：Julie A. Spicer、Gersande Lena、Dani M. Lyons、Kristiina M. Huttunen、Christian K. Miller、Patrick D. O’Connor、Matthew Bull、Nuala Helsby、Stephen M. F. Jamieson、William A. Denny、Annette Ciccone、Kylie A. Browne、Jamie A. Lopez、Jesse Rudd-Schmidt、Ilia Voskoboinik、Joseph A. Trapani

  DOI：10.1021/jm401604x

  日期：2013.12.12

  A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perform. Structure activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed 2-thioxoimidazolidin-4-one/thiophene core. The ability of the resulting compounds to inhibit the lytic activity of both isolated perform protein and perforin delivered in situ by natural killer cells was determined. A number of compounds showed excellent activity at concentrations that were nontoxic to the killer cells, and several were a significant improvement on previous classes of inhibitors, being substantially more potent and soluble. Representative examples showed rapid and reversible binding to immobilized mouse perforin at low concentrations (<= 2.5 mu M) by surface plasmon resonance and prevented formation of perforin pores in target cells despite effective target cell engagement, as determined by calcium influx studies. Mouse PK studies of two analogues showed T-1/2 values of 1.1-1.2 h (dose of 5 mg/kg iv) and MTDs of 60-80 mg/kg (ip).