3-butoxybut-1-ene | 37027-60-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-butoxybut-1-ene
• 英文别名: 3-Butoxy-1-buten；1-Butene, 3-butoxy-；1-but-3-en-2-yloxybutane
• CAS: 37027-60-4
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: CQJQTXVQMQMNBT-UHFFFAOYSA-N

物化性质

• 沸点：
  138.7±9.0 °C(Predicted)
• 密度：
  0.789±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-butoxybut-1-ene 在 仲丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 2-butoxy-2-methyl-1-phenylbut-3-enyl isobutyrate
  参考文献：
  名称：

  A Metathesis-Based Approach to the Synthesis of Furans

  摘要：

  The enol ether-olefin ring-closing metathesis reaction has been employed to generate 2,3-dihydrofurans that are equipped with a leaving group. These substrates are at the correct oxidation state to undergo an acid-catalyzed aromatization, and this strategy has been utilized to provide a mild and rapid route (four steps) to a range of novel 2,5-disubstituted furans.

  DOI：

  10.1021/ol062933r
• 作为产物：
  描述：

  正溴丁烷 、 3-丁烯-2-醇 在 四丁基碘化铵 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以55%的产率得到3-butoxybut-1-ene
  参考文献：
  名称：

  A Metathesis-Based Approach to the Synthesis of Furans

  摘要：

  The enol ether-olefin ring-closing metathesis reaction has been employed to generate 2,3-dihydrofurans that are equipped with a leaving group. These substrates are at the correct oxidation state to undergo an acid-catalyzed aromatization, and this strategy has been utilized to provide a mild and rapid route (four steps) to a range of novel 2,5-disubstituted furans.

  DOI：

  10.1021/ol062933r

文献信息

• PROCESS FOR DOUBLE CARBONYLATION OF ALLYL ETHERS TO CORRESPONDING DIESTERS
  申请人：EVONIK DEGUSSA GMBH

  公开号：US20170174609A1

  公开（公告）日：2017-06-22

  The invention relates to a process for doubly carbonylating allyl ethers to the corresponding diesters, wherein a linear or branched allyl ether is reacted with a linear or branched alkanol (alcohol) with supply of CO and in the presence of a catalytic system composed of a palladium complex and at least one organic phosphorus ligand and in the presence of a hydrogen halide selected from HCl, HBr and HI.

  该发明涉及一种将烯丙醚双羰基化为相应的二酯的过程，其中线性或支链烯丙醚与线性或支链烷醇（醇类）在供应CO的条件下，在钯络合物和至少一种有机磷配体组成的催化体系以及氢卤化物（HCl、HBr和HI）存在下反应。
• Reaction of 1,3-Dienes with Nucleophiles Catalysed by [1,2-Bis(dialkylphosphino)-ethane] palladium Complexes
  作者：P. W. Jolly、N. Kokel

  DOI：10.1055/s-1990-27010

  日期：——

  A(η2-butadiene)[1,2-bis(dialkylphosphino)ethane]palladium complex catalyses the reaction of 1,3-dienes with active hydrogen compounds or alcohols to give 1:1 adducts in high yield under moderate conditions.

  A(η2-丁二烯)[1,2-双(膦基烷基)乙烷]钯复合物在温和条件下催化1,3-二烯与活性氢化合物或醇的反应，生成高产率的1:1加合物。
• Processes for the preparation of n-butyraldehyde, n-butanol and mixtures
  申请人：BASF Aktiengesellschaft

  公开号：US06166265A1

  公开（公告）日：2000-12-26

  Process for the preparation of n-butyraldehyde and/or n-butanol, wherein a) 1,3-Butadiene or a butadiene-containing hydrocarbon mixture is reacted with an alcohol of the formula I ROH I, where R is C.sub.2 -C.sub.20 -alkyl or alkenyl which is unsubstituted or substituted by 1 or 2 C.sub.1 -C.sub.10 -alkoxy or hydroxyl groups, or is C.sub.6 -C.sub.10 -aryl, C.sub.7 -C.sub.11 -aralkyl or methyl, at elevated temperatures and superatmospheric pressure in the presence of a Bronsted acid or in the presence of a complex of an element of Group Ia, VIIA or VIIIA of the Periodic Table of Elements with phosphorus- or nitrogen-containing ligands to give a mixture of the adducts of the formulae II ##STR1## and III ##STR2## b) the adduct III is isomerized to the adduct II, c) the adduct II is converted into the acetal of the formula IV ##STR3## d) n-butyraldehyde and/or n-butanol are then produced from this acetal IV by reacting it, in the liquid phase, with hydrogen and water or water in the presence of a homogeneous or heterogeneous transition metal catalyst which differs from dicobaltoctacarbonyl or hydridocobalttetracarbonyl.

  制备正丁醛和/或正丁醇的方法，其中a）1,3-丁二烯或含有丁二烯的烃混合物与具有化学式I ROH I的醇发生反应，其中R是未取代或取代1或2个C1-C10-烷氧基或羟基的C2-C20-烷基或烯基，或者是C6-C10-芳基，C7-C11-芳基甲基，在高温和超大气压下，在Brønsted酸的存在下或在元素Ia、VIIA或VIIIA的复合物的存在下与含磷或氮配体的配体发生反应，生成化学式II和III的加合物混合物；b）将加合物III异构化为加合物II；c）将加合物II转化为化学式IV的缩醛；d）然后通过在液相中与过渡金属催化剂反应，以水和氢或水的存在下，从该缩醛IV生产正丁醛和/或正丁醇。
• ORAL COMBINATION THERAPY FOR TREATING HCV INFECTION IN SPECIFIC PATIENT SUBGENOTYPE POPULATIONS
  申请人：MENSA Federico

  公开号：US20130288957A1

  公开（公告）日：2013-10-31

  The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) Compound (2), or a pharmaceutically acceptable salt thereof, as herein described, and optionally (c) ribavirin, and methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in a patient that has genetic variations located near the IL28B gene, including SNP rs12979860 with a CC or non-CC genotype and SNP rs8099917 with a TT or non-TT genotype.

  本发明涉及包括（a）本文所述的化合物（1）或其药学上可接受的盐，（b）本文所述的化合物（2）或其药学上可接受的盐，以及可选的（c）利巴韦林的治疗组合，以及使用这种治疗组合治疗HCV感染或减轻患有位于IL28B基因附近的遗传变异的患者的一种或多种症状的方法，包括具有CC或非CC基因型的SNP rs12979860和具有TT或非TT基因型的SNP rs8099917。
• Catalyst system and method for carbonylation
  申请人：——

  公开号：US20030191339A1

  公开（公告）日：2003-10-09

  The invention relates to a catalyst system for carbonylating olefinically or acetylenically unsaturated compounds with carbon monoxide and a nucleophile compound, containing (a) palladium; (b) a phosphine and (c) a polymer containing nitrogen which is soluble in the reaction mixture, with the exception of polyvinyl polymers with aromatic radicals containing nitrogen on the polymer chain. The invention also relates to a method for carbonylation in the presence of one such catalyst system.

  这项发明涉及一种催化剂体系，用于将烯烃或乙炔不饱和化合物与一氧化碳和亲核试剂进行羰基化，包含(a) 钯；(b) 一种膦和(c) 一种含氮的聚合物，在反应混合物中可溶解，但不包括聚乙烯基链上含氮芳香基团的聚乙烯基聚合物。该发明还涉及在一种这样的催化剂体系存在下进行羰基化的方法。