Bis-(diethylamino-5-valeryl)-2,7-fluorenon-9 | 34924-27-1

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: Bis-(diethylamino-5-valeryl)-2,7-fluorenon-9
• 英文别名: 2,7-Bis[5-(Diethylamino)Valeryl]Fluoren-9-one；2,7-Bis[5-(diethylamino)pentanoyl]fluoren-9-one
• CAS: 34924-27-1
• 化学式: C₃₁H₄₂N₂O₃
• 分子量: 490.686
• InChiKey: SPIUQDGDQIPORX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  36
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氯代戊酰氯 在 三氯化铝 、 氧气 、 苄基三甲基氢氧化铵 、 potassium iodide 作用下， 以 四氢呋喃 、 吡啶 、 乙醇 为溶剂， 生成 Bis-(diethylamino-5-valeryl)-2,7-fluorenon-9
  参考文献：
  名称：

  双碱性取代的多环芳族化合物。一类新的抗病毒药物。3.2，7-双（氨基酰基）芴和-芴酮。

  摘要：

  DOI：

  10.1021/jm00254a021

文献信息

• Pharmaceutically useful bis-amine derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03947593A1

  公开（公告）日：1976-03-30

  Compounds of the following general structure are useful in treating conditions of delayed hypersensitivity: ##EQU1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, carbazole, N-(lower) alkyl carbazole or anthraquinone; Y represents carbonyl, divalent sulfur or oxygen; with the proviso that when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms; and each of R.sup.1 and R.sup.2 represents hydrogen, lower alkyl of from 1 to 4 carbon atoms, or alkenyl of from 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position; and pharmaceutically useful acid addition salts thereof.

  以下一般结构的化合物在治疗延迟型过敏症状方面很有用：其中[W]代表从芴烯、芴、芴-9-醇、芴-9-酮、咔唑、N-(较低)烷基咔唑或蒽醌中选择的芳香多环核；Y代表羰基、二价硫或氧；但当Y为羰基时，[W]不是芴-9-醇或蒽醌；A代表由1至6个碳原子的直链或支链烷基链；R.sup.1和R.sup.2分别代表氢、由1至4个碳原子的低烷基，或者由3至6个碳原子组成的烯烃，其乙烯不饱和度不在1位；以及其药用酸盐。
• Bis-basic ketones of fluorene and fluorenone
  申请人：Richardson-Merrell Inc.

  公开号：US04064347A1

  公开（公告）日：1977-12-20

  The novel bis-basic ketones of fluorene and fluorenone of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##STR1## wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group ##STR2## wherein R.sup.1 and R.sup.2 are individually hydrogen, (lower)alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group ##STR3## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, (lower)alkyl of 1 to about 4 carbon atoms, phenyl, or benzyl and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group ##STR4## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or (lower)alkyl of from 1 to about 4 carbon atoms; or D. the group ##STR5## WHEREIN P IS A WHOLE INTEGER FROM 2 TO 3, AND M IS A WHOLE INTEGER FROM 1 TO 2; OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT OF SAID BASE. These new compounds may be prepared by several different methods which are described.

  本发明的萘和萘醌的双碱基酮具有口服和非口服给药时的抗病毒活性。这些化合物由以下式表示： 其中Z为氧或H.sub.2；每个A为具有1到约6个碳原子的直链或支链烷基链；每个Y为A。组 其中R.sup.1和R.sup.2分别为氢、（较低）烷基，具有1到约6个碳原子，环烷基，具有3到6个碳原子，烯烃，具有3到6个碳原子，并且烯烃基团的烯丙烯不在烯烃基团的1位；或B。组 其中N为4到6的整数，R.sup.3为氢、1到约4个碳原子的（较低）烷基，苯基或苄基，并且可以连接到杂环基团的任一碳原子；或C。组 其中X为氧或NR.sup.4，R.sup.4为氢或1到约4个碳原子的（较低）烷基；或D。组 其中P为2到3的整数，M为1到2的整数；或所述碱的药学上可接受的酸加盐。这些新化合物可以通过描述的几种不同方法制备。
• US3947593A
  申请人：——

  公开号：US3947593A

  公开（公告）日：1976-03-30
• US4064347A
  申请人：——

  公开号：US4064347A

  公开（公告）日：1977-12-20
• Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones
  作者：William L. Albrecht、Robert W. Fleming、Stephen W. Horgan、James C. Kihm、Gerald D. Mayer

  DOI：10.1021/jm00254a021

  日期：1974.8