(2E,2'E)-N,N'-(ethane-1,2-diyl)bis(N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide) | 1449232-06-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2E,2'E)-N,N'-(ethane-1,2-diyl)bis(N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide)
• 英文别名: (E)-N-methyl-N-[2-[methyl-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]amino]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
• CAS: 1449232-06-7
• 化学式: C₂₈H₃₆N₂O₈
• 分子量: 528.602
• InChiKey: SHXRSEZNPHIGEY-WGDLNXRISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  38
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride 、 N,N'-二甲基乙二胺 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 (2E,2'E)-N,N'-(ethane-1,2-diyl)bis(N-methyl-3-(3,4,5-trimethoxyphenyl)acrylamide)
  参考文献：
  名称：

  Synthesis of piperlogs and analysis of their effects on cells

  摘要：

  Piperlongumine (PL) is a naturally occurring small molecule previously shown to induce cell death preferentially in cancer cells relative to non-cancer cells. An initial effort to synthesize analogs highlighted the reactivities of both of piperlongumine's alpha,beta-unsaturated imide functionalities as key features determining PL's cellular effects. In this study, a second-generation of analogs was synthesized and evaluated in cells to gain further insight into how the reactivity, number, and orientation of PL's reactive olefins contribute to its ability to alter the physiology of cells. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.080

文献信息

• Synthesis of piperlogs and analysis of their effects on cells
  作者：Zarko V. Boskovic、Mahmud M. Hussain、Drew J. Adams、Mingji Dai、Stuart L. Schreiber

  DOI：10.1016/j.tet.2013.05.080

  日期：2013.9

  Piperlongumine (PL) is a naturally occurring small molecule previously shown to induce cell death preferentially in cancer cells relative to non-cancer cells. An initial effort to synthesize analogs highlighted the reactivities of both of piperlongumine's alpha,beta-unsaturated imide functionalities as key features determining PL's cellular effects. In this study, a second-generation of analogs was synthesized and evaluated in cells to gain further insight into how the reactivity, number, and orientation of PL's reactive olefins contribute to its ability to alter the physiology of cells. (C) 2013 Elsevier Ltd. All rights reserved.