9-bromo-2-methyl-6,12-dihydroquinolino[3,4-b][1,4]benzothiazin-6(5H)-one | 1253049-40-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-bromo-2-methyl-6,12-dihydroquinolino[3,4-b][1,4]benzothiazin-6(5H)-one
• 英文别名: 9-Bromo-2-methyl-5,12-dihydroquinolino[3,4-b][1,4]benzothiazin-6-one
• CAS: 1253049-40-9
• 化学式: C₁₆H₁₁BrN₂OS
• 分子量: 359.246
• InChiKey: LEGGRFUJQALHBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟基-6-甲基-2-喹啉酮 、 2-氨基-5-溴苯硫醇 在 二甲基亚砜 作用下， 反应 1.0h， 以72%的产率得到9-bromo-2-methyl-6,12-dihydroquinolino[3,4-b][1,4]benzothiazin-6(5H)-one
  参考文献：
  名称：

  Synthesis and antioxidant activity of quinolinobenzothiazinones

  摘要：

  A new series of structurally diverse quinolinobenzothiazinones has been synthesized with the annulation of heterocyclic structural pharmacophores. The synthesized quinolinobenzothiazinones have been evaluated for their antioxidant (LPO & GSH) and radical scavenging activities (DPPH and ABTS assays). (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.07.006

文献信息

• Synthesis and antioxidant activity of quinolinobenzothiazinones
  作者：M. Kumar、Kshitija Sharma、R.M. Samarth、A. Kumar

  DOI：10.1016/j.ejmech.2010.07.006

  日期：2010.10

  A new series of structurally diverse quinolinobenzothiazinones has been synthesized with the annulation of heterocyclic structural pharmacophores. The synthesized quinolinobenzothiazinones have been evaluated for their antioxidant (LPO & GSH) and radical scavenging activities (DPPH and ABTS assays). (C) 2010 Elsevier Masson SAS. All rights reserved.