8-Amino-6-methoxy-5-(4-methoxyphenoxy)-4-methylquinoline | 82333-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Amino-6-methoxy-5-(4-methoxyphenoxy)-4-methylquinoline
• 英文别名: 6-Methoxy-5-(4-methoxyphenoxy)-4-methylquinolin-8-amine
• CAS: 82333-44-6
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: YVRCDWQHMUTCIK-UHFFFAOYSA-N

物化性质

• 熔点：
  185-187 °C
• 沸点：
  503.2±50.0 °C(Predicted)
• 密度：
  1.222±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-Amino-6-methoxy-5-(4-methoxyphenoxy)-4-methylquinoline 在 一水合肼 、 三乙胺 作用下， 以 乙二醇乙醚 、 乙醇 为溶剂， 反应 12.5h， 生成 8-((4-Amino-1-methylbutyl)amino)-6-methoxy-5-(4-methoxyphenoxy)-4-methyl-quinoline
  参考文献：
  名称：

  Antimalarials. 14. 5-(Aryloxy)-4-methylprimaquine analogs. A highly effective series of blood and tissue schizonticidal agents

  摘要：

  A series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity. The compounds were tested for suppressive activity against Plasmodium berghei in mice and for radical curative activity against Plasmodium cynomolgi in the rhesus monkey. The compounds were not only significantly superior to primaquine as radical curative agents but also were suprisingly highly effective as suppressive agents.

  DOI：

  10.1021/jm00351a017
• 作为产物：
  描述：

  5-chloro-6-methoxy-4-methyl-8-nitroquinoline 在 镍 氢氧化钾 、 氢气 作用下， 以 1,4-二氧六环 、 乙二醇乙醚 、 乙醇 为溶剂， 反应 9.25h， 生成 8-Amino-6-methoxy-5-(4-methoxyphenoxy)-4-methylquinoline
  参考文献：
  名称：

  Antimalarials. 14. 5-(Aryloxy)-4-methylprimaquine analogs. A highly effective series of blood and tissue schizonticidal agents

  摘要：

  A series of five 5-(aryloxy)-4-methylprimaquine analogues has been prepared and evaluated for antimalarial activity. The compounds were tested for suppressive activity against Plasmodium berghei in mice and for radical curative activity against Plasmodium cynomolgi in the rhesus monkey. The compounds were not only significantly superior to primaquine as radical curative agents but also were suprisingly highly effective as suppressive agents.

  DOI：

  10.1021/jm00351a017

文献信息

• LAMONTAGNE, M. P.;BLUMBERGS, P.;STRUBE, R. E., J. MED. CHEM., 1982, 25, N 9, 1094-1097
  作者：LAMONTAGNE, M. P.、BLUMBERGS, P.、STRUBE, R. E.

  DOI：——

  日期：——
• US4431807A
  申请人：——

  公开号：US4431807A

  公开（公告）日：1984-02-14