4-acetyl-N-isopropylaniline | 73008-78-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetyl-N-isopropylaniline
• 英文别名: 1-(4-(isopropylamino)phenyl)ethanone；1-[4-(Propan-2-ylamino)phenyl]ethanone
• CAS: 73008-78-3
• 化学式: C₁₁H₁₅NO
• mdl: MFCD16469422
• 分子量: 177.246
• InChiKey: NMABRGMEWAFXNO-UHFFFAOYSA-N

物化性质

• 沸点：
  303.6±25.0 °C(Predicted)
• 密度：
  1.019±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-acetyl-N-isopropylaniline 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 甲苯 为溶剂， 生成 1-(3-Bromo-4-isopropylamino-phenyl)-ethanone
  参考文献：
  名称：

  Asato, Goro; Baker, Pamela K.; Bass, Roy T., Agricultural and Biological Chemistry, 1984, vol. 48, # 11, p. 2883 - 2888

  摘要：

  DOI：
• 作为产物：
  描述：

  对羟基苯乙酮 在 氢氧化钾 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 8.5h， 生成 4-acetyl-N-isopropylaniline
  参考文献：
  名称：

  Goswami; Goswami; Borthakur, Journal of Chemical Research - Part S, 1996, # 9, p. 424 - 425

  摘要：

  DOI：

文献信息

• Alkylation of Amines with Alcohols and Amines by a Single Catalyst under Mild Conditions
  作者：Qingzhu Zou、Chao Wang、Jen Smith、Dong Xue、Jianliang Xiao

  DOI：10.1002/chem.201501109

  日期：2015.6.26

  An efficient catalytic system for the alkylation of amines with either alcohols or amines under mild conditions has been developed, using cyclometallated iridium complexes as catalysts. The method has broad substrate scope, allowing for the synthesis of a diverse range of secondary and tertiary amines with good to excellent yields. By controlling the ratio of substrates, both mono‐ and bis‐alkylated

  使用环金属化铱配合物作为催化剂，已经开发出一种在温和条件下将胺与醇或胺烷基化的有效催化体系。该方法具有广泛的底物范围，允许以良好或优异的产率合成多种范围的仲胺和叔胺。通过控制底物的比例，可以高选择性获得单烷基化胺和双烷基化胺。特别是，甲醇可用作烷基化试剂，选择性地提供N-甲基化产物。对于该反应观察到强溶剂作用。
• Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same
  申请人：Tzeng Cherng-Chyi

  公开号：US20090111987A1

  公开（公告）日：2009-04-30

  Disclosed herein are novel imino-indeno[1,2-c]quinoline derivatives of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these derivatives, their synthetic precursors and their uses in the manufacture of pharmaceutical compositions for use in the treatment of cancers.

  本文披露了一种新型的imino-indeno[1,2-c]quinoline衍生物，其化学式为(I)：或其药用可接受的盐或溶剂，其中每个取代基的定义如规范和权利要求所述。还披露了这些衍生物的制备过程、它们的合成前体以及它们在制造用于治疗癌症的药物组合物中的用途。
• NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF
  申请人：Franklin Richard

  公开号：US20110015182A1

  公开（公告）日：2011-01-20

  Carbamate linked prodrugs of meptazinol and other opioid analgesics are provided. The prodrug moiety may comprise a single amino acid or short peptide. Additionally, the present invention relates to methods for reducing gastrointestinal side effects in a subject, the gastrointestinal side effects being associated with the administration of an opioid analgesic. The methods comprise orally administering an opioid prodrug or pharmaceutically acceptable salt thereof to a subject, wherein the opioid prodrug is comprised of an opioid analgesic covalently bonded through a carbamate linkage to a prodrug moiety, and wherein upon oral administration, the prodrug or pharmaceutically acceptable salt minimizes at least one gastrointestinal side effect associated with oral administration of the opioid analgesic alone. Compositions for use with the method are also provided.

  本发明提供了与咪哌唑酮和其他阿片类镇痛剂相关的氨基甲酸酯前药。前药基团可以包括单个氨基酸或短肽。此外，本发明涉及减少受试者胃肠道副作用的方法，其中胃肠道副作用与阿片类镇痛剂的给药有关。该方法包括口服给受试者阿片类前药或其药学上可接受的盐，其中阿片类前药由阿片类镇痛剂通过氨基甲酸酯键共价结合到前药基团上，且在口服给药时，前药或药学上可接受的盐至少减少与单独口服阿片类镇痛剂有关的一个胃肠道副作用。本发明还提供了用于该方法的组合物。
• <scp>Palladium‐Catalyzed</scp> Tandem Cyclization Strategy for the Assembly of <scp>3‐Halo</scp> ‐1,2,5‐triarylpyrroles from <scp> <i>N</i> ‐Alkylanilines </scp> and Haloalkynes
  作者：Songjia Fang、Huanfeng Jiang、Wanqing Wu

  DOI：10.1002/cjoc.202200422

  日期：2023.1.15

  This report discloses a distinctive palladium-catalyzed sequential tandem cyclization reaction of two molecular haloalkynes and one molecular N-alkylanilines, leading to the efficient assembly of various 3-halo-1,2,5-triarylpyrrole derivatives. Two carbon-carbon triple bonds and one carbon-halogen bond in two molecular haloalkynes are transformed conveniently in one single step, which may involve the

  该报告公开了一种独特的钯​​催化的两个分子卤代炔烃和一个分子N -烷基苯胺的顺序串联环化反应，导致各种 3-卤代-1,2,5-三芳基吡咯衍生物的有效组装。两个分子卤代炔烃中的两个碳碳三键和一个碳卤键可以一步方便地转化，这可能涉及卤代炔烃的氨基炔基化和新形成的烯炔中间体的环化。卤代吡咯产品的高化学选择性和区域选择性、良好的官能团耐受性和后期修饰进一步说明了该策略的合成价值。
• Photoinduced Carbon−Heteroatom Cross‐Coupling Catalyzed by Nickel Naphthyridine Complexes
  作者：Janet Bahri、Shubham Deolka、Pavan K. Vardhanapu、Eugene Khaskin、Ramadoss Govindarajan、Robert R. Fayzullin、Serhii Vasylevskyi、Julia R. Khusnutdinova

  DOI：10.1002/cctc.202301142

  日期：2023.12.19

  and C‒O cross-coupling reactions catalyzed by NiII complexes supported by 2,7-dimethyl-1,8-naphthyridine ligand. Using the same Ni catalyst and visible light irradiation, both C‒O and C‒N coupling reactivity was observed without additional photocatalysts. These results demonstrate that Ni naphthyridine complexes represent a versatile catalytic motif for photoredox nickel catalysis alternative to commonly

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