bis(3-cyclohexen-1-ylmethyloxy)methane | 92860-41-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bis(3-cyclohexen-1-ylmethyloxy)methane
• 英文别名: bis(3-cyclohexen-1-yl-methoxy)methane；bis(3-cyclohexen-1-ylmethoxy)methane；Bis--monoformal；Bis-(cyclohexen-(3)-yl-methyl)-monoformal；4-(cyclohex-3-en-1-ylmethoxymethoxymethyl)cyclohexene
• CAS: 92860-41-8
• 化学式: C₁₅H₂₄O₂
• 分子量: 236.354
• InChiKey: WTLKZQAACUTNHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis(3-cyclohexen-1-ylmethyloxy)methane 、 2,4-喹唑啉二酮 在 N,O-双三甲硅基乙酰胺 、 三氟甲磺酸三甲基硅酯 作用下， 以 乙腈 为溶剂， 反应 5.17h， 以71%的产率得到1-(cyclohex-3-en-1-ylmethoxymethyl)quinazoline-2,4(1H,3H)-dione
  参考文献：
  名称：

  Synthesis of New Quinazoline-2,4(1H,3H)-dione non-nucleoside Analogues of the reverse transcriptase inhibitor TNK-651

  摘要：

  本研究介绍了从喹唑啉-2,4(1 H,3 H)-二酮合成一系列新型非核苷类逆转录酶抑制剂 TNK-651 的过程。化合物 2a-c 经硅烷化后，在 CsI 存在下用苄基氯甲基醚处理，得到 1-苄氧基甲基喹唑啉衍生物 3a-c。将硅烷化的喹唑啉二酮 2a-c 与相应的缩醛 5a-e 在三羟甲基三苯胺存在下进行处理，可得到相应的 TNK-651 类似物 6-10。

  DOI：

  10.3184/030823407x227101
• 作为产物：
  描述：

  聚合甲醛 、 3-环己烯-1-甲醇 生成 bis(3-cyclohexen-1-ylmethyloxy)methane
  参考文献：
  名称：

  838.缩醛和低聚缩醛。第一部分：反应性寡聚甲醛的制备和性质

  摘要：

  DOI：

  10.1039/jr9620004307

文献信息

• PROCESS FOR THE EPOXIDATION OF OLEFINS
  申请人：Chang Chun Plastics Co., Ltd.

  公开号：US20160083360A1

  公开（公告）日：2016-03-24

  The subject invention is related to a process for the epoxidation of olefin with peroxide, comprising reacting peroxide with olefin in the presence a solvent, wherein the solvent has Hansen Solubility Parameters (HSPs) of δ T,solvent and δ H,solvent and the epoxide product has Hansen Solubility Parameters (HSPs) of δ T,product and δ H,product , and wherein: δ T,product −6≦δ T,solvent ≦δ T,product +6, and δ H,product −6≦δ H,solvent .

  该发明涉及一种过氧化物与烯烃进行环氧化反应的方法，包括在溶剂存在的情况下，将过氧化物与烯烃反应，其中溶剂具有Hansen溶解度参数（HSPs）δT，溶剂和δH，溶剂，环氧产物具有Hansen溶解度参数（HSPs）δT，产物和δH，产物，并且满足以下条件：δT，产物-6≦δT，溶剂≦δT，产物+6，以及δH，产物-6≦δH，溶剂。
• Synthesis of Novel MKC-442 Analogues with Potent Activities against HIV-1
  作者：Nasser R. El-Brollosy、Erik B. Pedersen、Claus Nielsen

  DOI：10.1002/ardp.200300742

  日期：2003.7

  Bis(alken‐1‐yloxy)methanes 2 were synthesized by reacting 2‐cyclohexenol, 3‐cyclohexenylmethanol, cinnamyl alcohol and its α‐methyl analogue with dibromomethane. Condensation of 2 with 5, 6‐disubstituted uracil derivatives 1 resulted in the desired MKC‐442 analogues 3‐6. The most active compounds, N‐1 cinnamyloxymethyl‐ and N‐1 2‐methyl‐3‐phenylallyloxymethyl substituted 5‐ethyl‐6‐(3, 5‐dimethylbenzyl)uracils

  双(链烯-1-基氧基)甲烷2是通过2-环己烯醇、3-环己烯基甲醇、肉桂醇及其α-甲基类似物与二溴甲烷反应合成的。2 与 5, 6-二取代尿嘧啶衍生物 1 的缩合产生所需的 MKC-442 类似物 3-6。活性最强的化合物，N-1 肉桂氧基甲基-和 N-1 2-甲基-3-苯基烯丙氧基甲基取代的 5-乙基-6-（3, 5-二甲基苄基）尿嘧啶（5b 和 6b），对野生型 HIV-表现出活性1 在纳摩尔范围内，针对 Y181C 和 Y181C + K103N，已知对 MKC-442 具有抗性的突变菌株，在微摩尔范围内。
• Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides
  作者：Nasser R. El-Brollosy

  DOI：10.1007/s00706-008-0948-7

  日期：2008.12

  The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)6-azauracils and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria.
• Cleavable diepoxide for removable device protection in electronic packaging
  申请人：International Business Machines Corporation

  公开号：EP0532896B1

  公开（公告）日：1997-03-19
• CONTINUOUS PROCESS OF OLEFINIC EPOXIDATION BY SUPPORTED HETEROPOLY ACID
  申请人：Chang Chun Plastics Co., Ltd.

  公开号：US20160177023A1

  公开（公告）日：2016-06-23

  The subject invention is related to a continuous process of epoxidation of an olefin with supported heteropoly acid catalyst, which does not involve the use of an additive(s). The subject invention separates the products and oxides through a continuous process to reduce backmixing, thereby achieving an efficacy equal to that of a process involving the use of an additive. By excluding additives from the process, the subject invention has a lower cost, and avoids the need for additional wastewater treatment since no alkali metal or alkali earth metal compound is formed during the reaction. Moreover, the continuous process of the invention is also beneficial in industrial manufacturing.