1-Phenyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-ylamine | 230308-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Phenyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-ylamine
• 英文别名: 1-Phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-amine
• CAS: 230308-39-1
• 化学式: C₁₇H₁₅N₃
• mdl: MFCD01062725
• 分子量: 261.326
• InChiKey: IBYGZZKGKLQRQF-UHFFFAOYSA-N

物化性质

• 沸点：
  507.5±50.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-苯基-2-吡咯烷酮 在 sodium hexamethyldisilazane 、 三氯氧磷 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 8.0h， 生成 1-Phenyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-ylamine
  参考文献：
  名称：

  A novel and highly efficient synthesis of the aza analogs of tacrine

  摘要：

  We describe a new and efficient synthesis of the aza analogs of tacrine based upon the chemistry of the anionically activated trifluoromethyl group. We identify four sites (A-D) which can be successfully altered to afford the desired fused tricyclic heterocycles in high yield (63-82%). The reaction is believed to proceed through the formation of a quinone methide intermediate. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01122-3

文献信息

• A novel and highly efficient synthesis of the aza analogs of tacrine
  作者：Leon Smith、Alexander S. Kiselyov

  DOI：10.1016/s0040-4039(99)01122-3

  日期：1999.7

  We describe a new and efficient synthesis of the aza analogs of tacrine based upon the chemistry of the anionically activated trifluoromethyl group. We identify four sites (A-D) which can be successfully altered to afford the desired fused tricyclic heterocycles in high yield (63-82%). The reaction is believed to proceed through the formation of a quinone methide intermediate. (C) 1999 Elsevier Science Ltd. All rights reserved.