3-Hydroxy-4-amino-phenylalanin | 88686-28-6

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 丙氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Hydroxy-4-amino-phenylalanin
• 英文别名: 2-Amino-3-(4-amino-3-hydroxyphenyl)propanoic acid
• CAS: 88686-28-6
• 化学式: C₉H₁₂N₂O₃
• mdl: MFCD18647666
• 分子量: 196.206
• InChiKey: XHWPXBNFKWLGJH-UHFFFAOYSA-N

物化性质

• 沸点：
  424.8±45.0 °C(Predicted)
• 密度：
  1.420±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  α-Amino-β-(3-methoxy-4-aminophenyl)propionic acid dihydrochloride 在 氢碘酸 作用下， 反应 24.0h， 以95%的产率得到3-Hydroxy-4-amino-phenylalanin
  参考文献：
  名称：

  Synthesis and analysis of pheomelanin degradation products. 2

  摘要：

  DOI：

  10.1021/jo00180a009

文献信息

• Nicolaus,R.A. et al., Gazzetta Chimica Italiana, 1969, vol. 99, p. 323 - 350
  作者：Nicolaus,R.A. et al.

  DOI：——

  日期：——
• Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
  申请人：Miao Zhenwei

  公开号：US20080317670A1

  公开（公告）日：2008-12-25

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
• Synthesis and analysis of pheomelanin degradation products. 2
  作者：Dilip G. Patil、Miles R. Chedekel

  DOI：10.1021/jo00180a009

  日期：1984.3