N-benzyl-2-(2-fluorophenoxy)pyridine-3-carboxamide | 131236-86-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-benzyl-2-(2-fluorophenoxy)pyridine-3-carboxamide
• CAS: 131236-86-7
• 化学式: C₁₉H₁₅FN₂O₂
• 分子量: 322.339
• InChiKey: FRDSIUAQORPXQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯烟酸 在 N-甲基吗啉 、 sodium hydride 、 氯甲酸异丁酯 作用下， 反应 19.83h， 生成 N-benzyl-2-(2-fluorophenoxy)pyridine-3-carboxamide
  参考文献：
  名称：

  Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding

  摘要：

  The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of [H-3]rolipram to rat brain membranes and reverse reserpine-induced hypothermia in the mouse. Several compounds exhibited potent in vivo activity comparable to the standard agent, rolipram.

  DOI：

  10.1021/jm00105a015

文献信息

• VINICK, FREDRIC J.;SACCOMANO, NICHOLAS A.;KOE, B. KENNETH;NIELSEN, JANN A+, J. MED. CHEM., 34,(1991) N, C. 86-89
  作者：VINICK, FREDRIC J.、SACCOMANO, NICHOLAS A.、KOE, B. KENNETH、NIELSEN, JANN A+

  DOI：——

  日期：——
• Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding
  作者：Fredric J. Vinick、Nicholas A. Saccomano、B. Kenneth Koe、Jann A. Nielsen、Ian H. Williams、Peter F. Thadeio、Stanley Jung、Morgan Meltz、Jonathan Johnson、Lorraine A. Lebel、Lorena L. Russo、David Helweg

  DOI：10.1021/jm00105a015

  日期：1991.1

  The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of [H-3]rolipram to rat brain membranes and reverse reserpine-induced hypothermia in the mouse. Several compounds exhibited potent in vivo activity comparable to the standard agent, rolipram.