2-叠氮基-4-苯基-1,3-噻唑 | 62263-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-叠氮基-4-苯基-1,3-噻唑
• 英文名称: 4-Phenyl-2-azido-thiazol
• 英文别名: 2-azido-4-phenyl-thiazole；2-Azido-4-phenyl-1,3-thiazole
• CAS: 62263-00-7
• 化学式: C₉H₆N₄S
• 分子量: 202.239
• InChiKey: GWDGKCZBYKDHTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-叠氮基-4-苯基-1,3-噻唑 在 水 、 potassium carbonate 、 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 生成 5-methyl-1-(4-phenylthiazol-2-yl)-1H-1,2,3-triazole-4-carboxylic acid
  参考文献：
  名称：

  Evaluation of the antiproliferative activity of selected 1,2,3-triazole-4-carboxylic acids — key fragments and precursors of antitumor 1,2,3-triazole-4-carboxamides

  摘要：

  DOI：

  10.7124/bc.000a5c
• 作为产物：
  描述：

  2-氨基-4-苯基噻唑 在 磷酸 、 硝酸 、 sodium nitrite 、 sodium azide 作用下， 以 水 为溶剂， 以23%的产率得到2-叠氮基-4-苯基-1,3-噻唑
  参考文献：
  名称：

  Synthesis of 2-Azido-1,3-thiazoles as 1,2,3-Triazole Precursors

  摘要：

  By diazotization of 2-aminothiazoles and reaction with sodium azide, the derivatives of 2-azidothiazole were synthesized. Conditions of diazotization were selected according to the nature of a substituent in thiazoles. 2-Azidothiazole derivatives were studied in the base-catalysed condensation reactions with activated methylenic compounds to yield new 1-(1,3-thiazol-2-yl)-1H-1,2,3-triazole-4-carboxylic acids.

  DOI：

  10.1080/00397910902981274

文献信息

• Dehuri, S. N.; Pradhan, P. C.; Nayak, A., Journal of the Indian Chemical Society, 1983, vol. 60, p. 475 - 478
  作者：Dehuri, S. N.、Pradhan, P. C.、Nayak, A.

  DOI：——

  日期：——
• Synthesis of 2-Azido-1,3-thiazoles as 1,2,3-Triazole Precursors
  作者：Nazariy T. Pokhodylo、Roman D. Savka、Nazar I. Pidlypnyi、Vasyl S. Matiychuk、Mykola D. Obushak

  DOI：10.1080/00397910902981274

  日期：2010.1.14

  By diazotization of 2-aminothiazoles and reaction with sodium azide, the derivatives of 2-azidothiazole were synthesized. Conditions of diazotization were selected according to the nature of a substituent in thiazoles. 2-Azidothiazole derivatives were studied in the base-catalysed condensation reactions with activated methylenic compounds to yield new 1-(1,3-thiazol-2-yl)-1H-1,2,3-triazole-4-carboxylic acids.
• Evaluation of the antiproliferative activity of selected 1,2,3-triazole-4-carboxylic acids — key fragments and precursors of antitumor 1,2,3-triazole-4-carboxamides
  作者：N. T. Pokhodylo、V. S. Matiychuk

  DOI：10.7124/bc.000a5c

  日期：2021.8.31