p-tert-amyloxy-benzaldehyde | 80166-76-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: p-tert-amyloxy-benzaldehyde
• 英文别名: 4-(2-Methylbutan-2-yloxy)benzaldehyde
• CAS: 80166-76-3
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: ZQMMVTTVTQGDFP-UHFFFAOYSA-N

物化性质

• 沸点：
  290.8±13.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-tert-amyloxy-benzaldehyde 在 sodium hydroxide 哌啶 、 sodium tetrahydroborate 、 N,N-二甲基甘氨酸 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 4.0h， 生成 5-[4-(1,1-Dimethyl-propoxy)-benzyl]-thiazolidine-2,4-dione
  参考文献：
  名称：

  Structure–activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

  摘要：

  Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The anticancer effect of troglitazone was reported to be mediated by depletion of intracellular calcium stores resulting in inhibition of translation initiation. The unsaturated form of troglitazone displays similar anticancer properties in vitro. In this letter, we report our findings on the minimum structural requirements for both compounds to retain their calcium release and antiproliferative activities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.087
• 作为产物：
  描述：

  2-甲基-2-丁醇 、 对氟苯甲醛 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 p-tert-amyloxy-benzaldehyde
  参考文献：
  名称：

  Structure–activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

  摘要：

  Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The anticancer effect of troglitazone was reported to be mediated by depletion of intracellular calcium stores resulting in inhibition of translation initiation. The unsaturated form of troglitazone displays similar anticancer properties in vitro. In this letter, we report our findings on the minimum structural requirements for both compounds to retain their calcium release and antiproliferative activities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.087

文献信息

• Preparation of 1-(4-hydroxy-phenyl)-butan-3-one and novel intermediates
  申请人：BASF Aktiengesellschaft

  公开号：US04908481A1

  公开（公告）日：1990-03-13

  A simple process for preparing 1-(4-hydroxy-phenyl)-butan-3-one, a sought-after natural aromatic, in a pure form and in good yield from easily accessible starting materials, wherein a 4-tert-alkoxy-benzaldehyde is condensed, under alkaline conditions, to give a novel 1-(4-tert.-alkoxy-phenyl)-but-1-en-3-one, the latter is hydrogenated, during or after this condensation, to give a novel 1-(4-tert.-alkoxy-phenyl)-butan-3-one, and isobutene or 2-methyl-but-1(2)-ene is eliminated from this compound in the presence of a catalytic amount of an acid. The novel intermediates have the general formula ##STR1## where R is H or CH.sub.3 and the broken line may or may not be an additional carbon-carbon bond.

  一种简单的制备1-(4-羟基苯基)-丁酮的方法，该天然芳香物质易于获得，纯度高，收率好，其方法包括将4-叔-烷氧基苯甲醛在碱性条件下缩合，形成一种新的1-(4-叔-烷氧基苯基)-丁-1-烯-3-酮，然后在此缩合过程中或之后，对该中间体进行氢化，得到一种新的1-(4-叔-烷氧基苯基)-丁酮，并在存在催化酸的情况下，从该化合物中消除异丁烯或2-甲基-丁-1(2)-烯。新的中间体具有一般式##STR1##其中R为H或CH.sub.3，虚线可以是另一个碳-碳键或不是。
• Verfahren zur Herstellung von 1-(4-Hydroxy-phenyl)-butan-3-on sowie neue Zwischenprodukte dieses Verfahrens
  申请人：BASF Aktiengesellschaft

  公开号：EP0038480B1

  公开（公告）日：1983-09-21
• RESIST MULTILAYER FILM-ATTACHED SUBSTRATE AND PATTERNING PROCESS
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20190041753A1

  公开（公告）日：2019-02-07

  The present invention provides a resist multilayer film-attached substrate, including a substrate and a resist multilayer film formed on the substrate, in which the resist multilayer film has an organic resist underlayer film difficultly soluble in ammonia hydrogen peroxide water, an organic film soluble in ammonia hydrogen peroxide water, a silicon-containing resist middle layer film, and a resist upper layer film laminated on the substrate in the stated order. There can be provided a resist multilayer film-attached substrate that enables a silicon residue modified by dry etching to be easily removed in a wet manner with a removing liquid harmless to a semiconductor apparatus substrate and an organic resist underlayer film required in the patterning process, for example, an ammonia aqueous solution containing hydrogen peroxide called SC1, which is commonly used in the semiconductor manufacturing process.
• US4908481A
  申请人：——

  公开号：US4908481A

  公开（公告）日：1990-03-13
• Structure–activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium
  作者：Yun-Hua Fan、Han Chen、Amarnath Natarajan、Yuhong Guo、Fred Harbinski、Julia Iyasere、William Christ、Huseyin Aktas、Jose A. Halperin

  DOI：10.1016/j.bmcl.2004.02.087

  日期：2004.5

  Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The anticancer effect of troglitazone was reported to be mediated by depletion of intracellular calcium stores resulting in inhibition of translation initiation. The unsaturated form of troglitazone displays similar anticancer properties in vitro. In this letter, we report our findings on the minimum structural requirements for both compounds to retain their calcium release and antiproliferative activities. (C) 2004 Elsevier Ltd. All rights reserved.