(E)-3-(naphthalen-2-yl)acrylamide | 107622-49-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(naphthalen-2-yl)acrylamide
• 英文别名: (E)-3-naphthalen-2-ylprop-2-enamide
• CAS: 107622-49-1
• 化学式: C₁₃H₁₁NO
• 分子量: 197.236
• InChiKey: SQEPXJIYNPDPRZ-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲醇 、 (E)-3-(naphthalen-2-yl)acrylamide 在 sodium hypochlorite 作用下， 生成 (2-[2]naphthyl-vinyl)-carbamic acid methyl ester
  参考文献：
  名称：

  Gopinath et al., Journal of the Chemical Society, 1957, p. 1144,1146

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-3-(萘-2-基)丙烯酸 生成 (E)-3-(naphthalen-2-yl)acrylamide
  参考文献：
  名称：

  Gopinath et al., Journal of the Chemical Society, 1957, p. 1144,1146

  摘要：

  DOI：

文献信息

• Selective and facile synthesis of α,β-unsaturated nitriles and amides with N-hydroxyphthalimide as the nitrogen source
  作者：Yiyan Yan、Xiaohe Xu、Xiaokang Jie、Jingya Cheng、Renren Bai、Qi Shuai、Yuanyuan Xie

  DOI：10.1016/j.tetlet.2018.06.011

  日期：2018.7

  The direct conversion of α,β-unsaturated aldehydes to corresponding nitriles promoted by Pd(OAc)2 and phthalic acid which was hydrolyzed from N-hydroxyphthalimide (NHPI) has been disclosed. Additionally, it was found that when water was used as the solvent, α,β-unsaturated amides was obtained as the main products in good to excellent yields. It was first reported that NHPI was utilized as the nitrogen

  已经公开了由N-羟基邻苯二甲酰亚胺（NHPI）水解的Pd（OAc）2和邻苯二甲酸促进的α，β-不饱和醛直接转化为相应的腈。另外，发现当使用水作为溶剂时，以良好至优异的产率获得α，β-不饱和酰胺作为主要产物。首次报道，NHPI被用作氮源，由醛合成α，β-不饱和腈和酰胺。对照实验表明，醛经过肟化和脱水过程形成腈和酰胺。
• Proteasome inhibitors and methods of using the same
  申请人：Bernadini Raffaella

  公开号：US20050107307A1

  公开（公告）日：2005-05-19

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以通过抑制蛋白酶体活性等方式调节细胞凋亡。这些化合物和组合物可以用于诱导细胞凋亡并治疗癌症等疾病，以及与蛋白酶体活性直接或间接相关的其他疾病。
• PROTEASOME INHIBITORS AND METHODS OF USING THE SAME
  申请人：Bernardini Raffaella

  公开号：US20090291918A1

  公开（公告）日：2009-11-26

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节细胞凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可以用于诱导细胞凋亡和治疗癌症及其他与蛋白酶体活性直接或间接相关的疾病。
• Proteasome Inhibitors and Methods of Using the Same
  申请人：Bernardini Raffaella

  公开号：US20110144033A1

  公开（公告）日：2011-06-16

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节细胞凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可用于诱导细胞凋亡和治疗癌症和其他与蛋白酶体活性直接或间接相关的疾病的方法。
• Proteasome Inhibitors And Methods Of Using The Same
  申请人：Cephalon, Inc.

  公开号：US20140088042A1

  公开（公告）日：2014-03-27

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可以用于诱导凋亡和治疗癌症和其他与蛋白酶体活性直接或间接相关的疾病的方法。