Schwefeligsaeurediethylester | 29786-05-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Schwefeligsaeurediethylester
• 英文别名: O,O-diethyl thiosulfite；thiosulfurous acid O,O'-diethyl ester；Thioschwefligsaeure-O,O'-diaethylester；O,O'-Diaethyl-thiosulfit；Diaethoxydisulfid；Diethyl thiosulfite；diethoxy(sulfanylidene)-λ4-sulfane
• CAS: 29786-05-8
• 化学式: C₄H₁₀O₂S₂
• 分子量: 154.254
• InChiKey: XEQXXHHUQBSNHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Schwefeligsaeurediethylester 在 sodium ethanolate 作用下， 生成 diethoxysulfane
  参考文献：
  名称：

  Surgical Treatment of Severe Acute Pancreatitis: Timing of Operation is Crucial for Survival

  摘要：

  Background: In patients operated on for severe acute pancreatitis (SAP) the impact of the timing of operation on outcome is controversial. Materials and methods: In a retrospective analysis of a prospectively documented database, we studied 250 patients suffering from SAP, who were in need for surgical treatment during their course of disease. Results: From 1982 to 1998, 250 patients with the diagnosis of SAP who required operative treatment were admitted to the intensive care unit (ICU) of a university hospital. The mean APACHE II score on the day of admission was 16.1 (8-35). One hundred eighty-five patients (74%) required reoperation, of whom 111 patients (60%) underwent reoperation on demand and 74 (40%) patients a pre-planned reoperation. Overall mortality was 38.8% (97 patients). In patients who were operated during the first three weeks after onset of disease, mortality was significantly higher than in patients who were operated after three weeks (46% vs. 25%, p < 0.01). Besides patient age (p < 0.05), APACHE II score at admission (p < 0.01), multiple organ dysfunction (p < 0.01), infection of pancreatic necrosis (p < 0.05), surgical control of pancreatic necrosis (p < 0.0001), and the time of surgical intervention (p < 0.05) determined survival significantly. Conclusion: Patients who were operated later than three weeks after onset of disease had a significantly better outcome. In patients suffering from SAP who required surgical treatment, the timing of operation is crucial for survival.

  DOI：

  10.1089/109629603766957004
• 作为产物：
  描述：

  sodium ethanolate 在 二氯化二硫 作用下， 生成 Schwefeligsaeurediethylester
  参考文献：
  名称：

  A Sense of Life: Computational and Experimental Investigations with Models of Biochemical and Evolutionary Processes

  摘要：

  We collaborate in a research program aimed at creating a rigorous framework, experimental infrastructure, and computational environment for understanding, experimenting with, manipulating, and modifying a diverse set of fundamental biological processes at multiple scales and spatio-temporal modes. The novelty of our research is based on an approach that (i) requires coevolution of experimental science and theoretical techniques and (ii) exploits a certain universality in biology guided by a parsimonious model of evolutionary mechanisms operating at the genomic level and manifesting at the proteomic, transcriptomic, phylogenic, and other higher levels. Our current program in "systems biology" endeavors to marry large-scale biological experiments with the tools to ponder and reason about large, complex, and subtle natural systems. To achieve this ambitious goal, ideas and concepts are combined from many different fields: biological experimentation, applied mathematical modeling, computational reasoning schemes, and large-scale numerical and symbolic simulations. From a biological viewpoint, the basic issues are many: (i) understanding common and shared structural motifs among biological processes; (ii) modeling biological noise due to interactions among a small number of key molecules or loss of synchrony; (iii) explaining the robustness of these systems in spite of such noise; and (iv) cataloging multistatic behavior and adaptation exhibited by many biological processes.

  DOI：

  10.1089/153623103322452387

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: S: SVol.4a/b, 1.1.9.6, page 44 - 45
  作者：

  DOI：——

  日期：——
• Murthy, A. R. V., 1953, vol. 37, p. 11 - 16
  作者：Murthy, A. R. V.

  DOI：——

  日期：——
• Meuwsen, Chemische Berichte, 1936, vol. 69, p. 937
  作者：Meuwsen

  DOI：——

  日期：——
• Murthy, Proceedings - Indian Academy of Sciences, Section A, 1953, vol. 37, p. 11
  作者：Murthy

  DOI：——

  日期：——
• A Sense of Life: Computational and Experimental Investigations with Models of Biochemical and Evolutionary Processes
  作者：Bud Mishra、Raoul-Sam Daruwala、Yi Zhou、Nadia Ugel、Alberto Policriti、Marco Antoniotti、Salvatore Paxia、Marc Rejali、Archisman Rudra、Vera Cherepinsky、Naomi Silver、William Casey、Carla Piazza、Marta Simeoni、Paolo Barbano、Marina Spivak、Jiawu Feng、Ofer Gill、Mysore Venkatesh、Fang Cheng、Bing Sun、Iuliana Ioniata、Thomas Anantharaman、E. Jane Albert Hubbard、Amir Pnueli、David Harel、Vijay Chandru、Ramesh Hariharan、Michael Wigler、Frank Park、Shih-Chieh Lin、Yuri Lazebnik、Franz Winkler、Charles R. Cantor、Alessandra Carbone、Mikhael Gromov

  DOI：10.1089/153623103322452387

  日期：2003.9.26

  We collaborate in a research program aimed at creating a rigorous framework, experimental infrastructure, and computational environment for understanding, experimenting with, manipulating, and modifying a diverse set of fundamental biological processes at multiple scales and spatio-temporal modes. The novelty of our research is based on an approach that (i) requires coevolution of experimental science and theoretical techniques and (ii) exploits a certain universality in biology guided by a parsimonious model of evolutionary mechanisms operating at the genomic level and manifesting at the proteomic, transcriptomic, phylogenic, and other higher levels. Our current program in "systems biology" endeavors to marry large-scale biological experiments with the tools to ponder and reason about large, complex, and subtle natural systems. To achieve this ambitious goal, ideas and concepts are combined from many different fields: biological experimentation, applied mathematical modeling, computational reasoning schemes, and large-scale numerical and symbolic simulations. From a biological viewpoint, the basic issues are many: (i) understanding common and shared structural motifs among biological processes; (ii) modeling biological noise due to interactions among a small number of key molecules or loss of synchrony; (iii) explaining the robustness of these systems in spite of such noise; and (iv) cataloging multistatic behavior and adaptation exhibited by many biological processes.