1-(pyridin-4-yl)-2-(quinolin-2-yl)ethanol | 97980-32-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(pyridin-4-yl)-2-(quinolin-2-yl)ethanol
• 英文别名: 1-pyridin-4-yl-2-quinolin-2-yl-ethanol；1-Pyridyl-(4)-2-chinolyl-(2)-ethanol；1-Pyridin-4-yl-2-quinolin-2-ylethanol
• CAS: 97980-32-0
• 化学式: C₁₆H₁₄N₂O
• 分子量: 250.3
• InChiKey: BEFQREKYNCMWJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-吡啶甲醛 、 2-甲基喹啉 以 1,4-二氧六环 为溶剂， 反应 72.0h， 以53%的产率得到(E)-2-(2-(pyridin-4-yl)ethenyl)quinoline
  参考文献：
  名称：

  Catalyst-free synthesis of (E)-2-alkenylquinoline derivatives via C(sp3)-H functionalization of 2-methylquinolines

  摘要：

  This Letter described a facile approach to synthesize (E)-2-alkenylquinoline derivatives via C(sp(3))-H functionalization of 2-methylquinolines under catalyst-free conditions. A variety of electronically and sterically diverse 2-methyl quinoline and aromatic aldehydes were well tolerated. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.079

文献信息

• Catalyst-free synthesis of (E)-2-alkenylquinoline derivatives via C(sp3)-H functionalization of 2-methylquinolines
  作者：Lubin Xu、Zhuzhou Shao、Liang Wang、Huaili Zhao、Jian Xiao

  DOI：10.1016/j.tetlet.2014.10.079

  日期：2014.12

  This Letter described a facile approach to synthesize (E)-2-alkenylquinoline derivatives via C(sp(3))-H functionalization of 2-methylquinolines under catalyst-free conditions. A variety of electronically and sterically diverse 2-methyl quinoline and aromatic aldehydes were well tolerated. (C) 2014 Elsevier Ltd. All rights reserved.