(2R,4R)-4-[(4R)-nonadec-1-en-4-yl]oxypentan-2-ol | 307557-88-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,4R)-4-[(4R)-nonadec-1-en-4-yl]oxypentan-2-ol
• CAS: 307557-88-6
• 化学式: C₂₄H₄₈O₂
• 分子量: 368.644
• InChiKey: GRSNUTSMVZTIJL-SMIHKQSGSA-N

物化性质

• 沸点：
  463.1±28.0 °C(Predicted)
• 密度：
  0.867±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  26
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R,4R)-4-[(4R)-nonadec-1-en-4-yl]oxypentan-2-ol 在 sodium chlorite 、 sodium periodate 、 potassium dihydrogenphosphate 、 四氧化锇 、 N-甲基吲哚酮 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 生成 (R)-3-hydroxyoctadecanoic acid
  参考文献：
  名称：

  Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

  摘要：

  A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our sidechain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00424-8
• 作为产物：
  描述：

  十六醛 在 四氯化钛 、 对甲苯磺酸 作用下， 以 二氯甲烷 、 苯 为溶剂， 生成 (2R,4R)-4-[(4R)-nonadec-1-en-4-yl]oxypentan-2-ol
  参考文献：
  名称：

  Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

  摘要：

  A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our sidechain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00424-8

文献信息

• Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2
  作者：Shu-Hui Chen、Xicheng Sun、Robert Boyer、Jonathan Paschal、Doug Zeckner、William Current、Mark Zweifel、Michael Rodriguez

  DOI：10.1016/s0960-894x(00)00424-8

  日期：2000.9

  A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our sidechain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections. (C) 2000 Elsevier Science Ltd. All rights reserved.