pentafluoropropanol | 28302-70-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: pentafluoropropanol
• 英文别名: 1,1,2,2,3-pentafluoropropan-1-ol
• CAS: 28302-70-7
• 化学式: C₃H₃F₅O
• 分子量: 150.048
• InChiKey: COWKRCCNQSQUGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  pentafluoropropanol 、 AG221中间体C 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 2.17h， 生成 4-(2,2,3,3,3-pentafluoropropoxy)-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine
  参考文献：
  名称：

  CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF

  摘要：

  公开号：

  EP3489230B1

文献信息

• HYDROFLUOROACETAL COMPOUNDS AND PROCESSES FOR THEIR PREPARATION AND USE
  申请人：Flynn Richard M.

  公开号：US20090326083A1

  公开（公告）日：2009-12-31

  The present disclosure provides a compound according to the formula: R f 1 [CH(—O—CH (3-m) R f 2 m )(—O—CF 2 —CFH—R f 3 )] n [I] wherein n is 1 or 2, wherein m is 1, 2 or 3, wherein, when n is 1, R f 1 is selected from the group consisting of highly fluorinated alkyl groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms; wherein, when n is 2, R f 1 is selected from the group consisting of highly fluorinated alkylene groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms; wherein each R f 2 is independently selected from the group consisting of alkyl groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms; wherein at least one R f 2 is highly fluorinated; wherein each R f 3 is independently selected from the group consisting of fluorine and highly fluorinated alkyl groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms. Also provided are methods of use and manufacture of such compounds.

  本公开提供了一种按照式子Rf1[CH(—O—CH(3-m)Rf2m)(—O—CF2—CFH—Rf3)]n[I]的化合物，其中n为1或2，m为1、2或3，当n为1时，Rf1选自高度氟化的线性、支链、环状或其组合的烷基基团，可以选择性地被取代，并且可以选择性地包含一个或多个链合杂原子；当n为2时，Rf1选自高度氟化的线性、支链、环状或其组合的烷基烷基团，可以选择性地被取代，并且可以选择性地包含一个或多个链合杂原子；每个Rf2独立地选自线性、支链、环状或其组合的烷基基团，可以选择性地被取代，并且可以选择性地包含一个或多个链合杂原子；至少一个Rf2高度氟化；每个Rf3独立地选自氟和高度氟化的线性、支链、环状或其组合的烷基基团，可以选择性地被取代，并且可以选择性地包含一个或多个链合杂原子。还提供了这种化合物的使用和制造方法。
• Hydrofluoroacetal compounds and processes for their preparation and use
  申请人：3M Innovative Properties Company

  公开号：US08071816B2

  公开（公告）日：2011-12-06

  The present disclosure provides a compound according to the formula: Rf1[CH(—O—CH(3-m)Rf2m)(—O—CF2—CFH—Rf3)]n   [I] wherein n is 1 or 2, wherein m is 1, 2 or 3, wherein, when n is 1, Rf1 is selected from the group consisting of highly fluorinated alkyl groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms; wherein, when n is 2, Rf1 is selected from the group consisting of highly fluorinated alkylene groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms; wherein each Rf2 is independently selected from the group consisting of alkyl groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms; wherein at least one Rf2 is highly fluorinated; wherein each Rf3 is independently selected from the group consisting of fluorine and highly fluorinated alkyl groups which are linear, branched, cyclic, or a combination thereof, which may optionally be substituted, and which may optionally contain one or more catenated heteroatoms. Also provided are methods of use and manufacture of such compounds.

  本公开提供了一种化合物，其化学式为：Rf1 [CH（—O—CH（3-m）Rf2m）（—O—CF2—CFH—Rf3）]n [I]，其中n为1或2，m为1、2或3，当n为1时，Rf1选自高度氟化的直链、支链、环状或其组合的烷基基团，可选地取代，并可选地含有一个或多个串联的杂原子；当n为2时，Rf1选自高度氟化的直链、支链、环状或其组合的烷基烷基团，可选地取代，并可选地含有一个或多个串联的杂原子；每个Rf2独立地选自线性、支链、环状或其组合的烷基基团，可选地取代，并可选地含有一个或多个串联的杂原子；至少一个Rf2是高度氟化的；每个Rf3独立地选自氟和高度氟化的直链、支链、环状或其组合的烷基基团，可选地取代，并可选地含有一个或多个串联的杂原子。还提供了使用和制造这种化合物的方法。
• CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF
  申请人：Nanjing Sanhome Pharmaceutical Co., Ltd.

  公开号：EP3489230B1

  公开（公告）日：2021-12-08