8-<(4-amino-1-methylbutyl)amino>-5,6-dimethoxy-4-methylquinoline | 64992-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-<(4-amino-1-methylbutyl)amino>-5,6-dimethoxy-4-methylquinoline
• 英文别名: 4-N-(5,6-dimethoxy-4-methylquinolin-8-yl)pentane-1,4-diamine
• CAS: 64992-94-5
• 化学式: C₁₇H₂₅N₃O₂
• 分子量: 303.404
• InChiKey: WWJWTKNTQQNEOX-UHFFFAOYSA-N

物化性质

• 沸点：
  487.2±45.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  69.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-<(4-amino-1-methylbutyl)amino>-5,6-dimethoxy-4-methylquinoline 在 氢溴酸 作用下， 反应 48.0h， 以59%的产率得到8-<(4-amino-1-methylbutyl)amino>-5,6-dihydroxy-4-methylquinoline trihydrobromide
  参考文献：
  名称：

  Jain, Rahul; Gupta, R. C.; Anand, Nitya, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, # 8, p. 792 - 794

  摘要：

  DOI：
• 作为产物：
  描述：

  2-[4-(5,6-Dimethoxy-4-methyl-quinolin-8-ylamino)-pentyl]-isoindole-1,3-dione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 8-<(4-amino-1-methylbutyl)amino>-5,6-dimethoxy-4-methylquinoline
  参考文献：
  名称：

  Antimalarials. 13. 5-Alkoxy analogs of 4-methylprimaquine

  摘要：

  A series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. The compounds were tested for suppressive antimalarial activity against Plasmodium berghei in mice and for radical curative antimalarial activity against Plasmodium cynomolgi in the rhesus monkey. Although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly effective as both blood and tissue schizonticidal agents.

  DOI：

  10.1021/jm00350a016

文献信息

• Jain, Rahul; Jain, Sanjay; Gupta, R C, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, p. 251 - 254
  作者：Jain, Rahul、Jain, Sanjay、Gupta, R C、Anand, Nitya、Dutta, G P、Puri, S K

  DOI：——

  日期：——
• Methods and compositions for the treatment of neurodegenerative disorders
  申请人：Jin Xiaowei

  公开号：US20080044390A1

  公开（公告）日：2008-02-21

  The present invention features compositions, kits, and methods for treating, preventing, and ameliorating neurodegenerative disorders, e.g., Huntington's disease.
• US4167638A
  申请人：——

  公开号：US4167638A

  公开（公告）日：1979-09-11
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS
  申请人：COMBINATORX INC

  公开号：WO2008021210A2

  公开（公告）日：2008-02-21

  [EN] The present invention features compositions, kits, and methods for treating, preventing, and ameliorating neurodegenerative disorders, e.g., Huntington's disease.
  [FR] La présente invention comporte des compositions, des kits et des méthodes pour traiter, prévenir et guérir des troubles neurodégénératifs, par exemple, la maladie de Huntington.
• Antimalarials. 13. 5-Alkoxy analogs of 4-methylprimaquine
  作者：Maurice P. LaMontagne、Anica Markovac、M. Sami Khan

  DOI：10.1021/jm00350a016

  日期：1982.8

  A series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. The compounds were tested for suppressive antimalarial activity against Plasmodium berghei in mice and for radical curative antimalarial activity against Plasmodium cynomolgi in the rhesus monkey. Although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly effective as both blood and tissue schizonticidal agents.