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3-(1-methylindol-3-yl)-4-(3-nitrophenyl)furan-2,5-dione | 396090-99-6

中文名称
——
中文别名
——
英文名称
3-(1-methylindol-3-yl)-4-(3-nitrophenyl)furan-2,5-dione
英文别名
——
3-(1-methylindol-3-yl)-4-(3-nitrophenyl)furan-2,5-dione化学式
CAS
396090-99-6
化学式
C19H12N2O5
mdl
——
分子量
348.315
InChiKey
FELWTGXYEPONDU-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    605.4±55.0 °C(Predicted)
  • 密度:
    1.44±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    3.1
  • 重原子数:
    26
  • 可旋转键数:
    2
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.05
  • 拓扑面积:
    94.1
  • 氢给体数:
    0
  • 氢受体数:
    5

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    3-(1-methylindol-3-yl)-4-(3-nitrophenyl)furan-2,5-dione 在 palladium on activated charcoal ammonium hydroxide氢气 作用下, 以 四氢呋喃N,N-二甲基甲酰胺 为溶剂, 25.0~140.0 ℃ 、101.33 kPa 条件下, 反应 21.0h, 生成 3-(3-氨基苯基)-4-(1-甲基-1H-吲哚-3-基)吡咯-2,5-二酮
    参考文献:
    名称:
    Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides
    摘要:
    The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described. These 2,3-bisarylznaleimides were derived from the structural lead provided by the indolocarbazoles, staurosporine and K252a. Optimum activity required the imide NH, both carbonyl groups, and the olefinic bond of the maleimide ring. 2,3-Bisindolylmaleimides were the most active, and the potency of these was improved by a chloro substituent at the 5-position of one indole ring (compound 28, IC50 0.11-mu-M). In a series of (phenylindolyl)maleimides, nitro compound 74 was most active (IC50 0.67-mu-M). Naphthalene 19 and benzothiophene 21 showed greater than 100-fold selectivity for inhibition of PKC over the closely related cAMP-dependent protein kinase (PKA).
    DOI:
    10.1021/jm00079a024
  • 作为产物:
    参考文献:
    名称:
    Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides
    摘要:
    The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described. These 2,3-bisarylznaleimides were derived from the structural lead provided by the indolocarbazoles, staurosporine and K252a. Optimum activity required the imide NH, both carbonyl groups, and the olefinic bond of the maleimide ring. 2,3-Bisindolylmaleimides were the most active, and the potency of these was improved by a chloro substituent at the 5-position of one indole ring (compound 28, IC50 0.11-mu-M). In a series of (phenylindolyl)maleimides, nitro compound 74 was most active (IC50 0.67-mu-M). Naphthalene 19 and benzothiophene 21 showed greater than 100-fold selectivity for inhibition of PKC over the closely related cAMP-dependent protein kinase (PKA).
    DOI:
    10.1021/jm00079a024
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文献信息

  • 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
    申请人:——
    公开号:US20020052397A1
    公开(公告)日:2002-05-02
    This invention relates to inhibitors of glycogen synthase kinase- 3 &bgr;, methods of treating diseases characterized by an excess of Th 2 cytokines, and to 3 -indolyl- 4 -phenyl- 1 H-pyrrole- 2,5 -dione derivatives of Formula (I): 1 that are inhibitors of glycogen synthase kinase - 3 &bgr;, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    这项发明涉及抑制糖原合成酶激酶-3β的方法,用于治疗由Th2细胞因子过多引起的疾病,以及3-吲哚基-4-苯基-1H-吡咯-2,5-二酮衍生物的化合物(I)的方法:这些化合物是糖原合成酶激酶-3β的抑制剂,包含它们的药物组合物,使用它们的方法以及制备这些化合物的方法。
  • Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3 betta
    申请人:Syntex (U.S.A.) LLC
    公开号:US20030176484A1
    公开(公告)日:2003-09-18
    This invention relates to the use of inhibitors of glycogen synthase kinase-3&bgr; to increase bone formation.
    这项发明涉及利用糖原合成激酶-3β抑制剂来增加骨形成。
  • [EN] USE OF A GSK-3BETA INHIBITOR IN THE MANUFACTURE OF A MEDICAMENT FOR INCREASING BONE FORMATION<br/>[FR] UTILISATION D'UN INHIBITEUR DE GSK-3 BETA DANS LA FABRICATION D'UN MEDICAMENT POUR ACCROITRE LA FORMATION OSSEUSE
    申请人:HOFFMANN LA ROCHE
    公开号:WO2003057202A1
    公开(公告)日:2003-07-17
    This invention relates to the use of inhibitors of glycogen synthase kinase-3β to increase bone formation.
    本发明涉及使用糖原合酶激酶-3β抑制剂来增加骨形成。
  • 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3&bgr;
    申请人:Syntex (U.S.A.) LLC
    公开号:US06479490B2
    公开(公告)日:2002-11-12
    This invention relates to inhibitors of glycogen synthase kinase-3&bgr;, methods of treating diseases characterized by an excess of Th2 cytokines, and to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I): that are inhibitors of glycogen synthase kinase -3&bgr;, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    本发明涉及抑制糖原合成酶激酶-3β,治疗由Th2细胞因子过量引起的疾病的方法,以及公式(I)的3-吲哚基-4-苯基-1H-吡咯-2,5-二酮衍生物,它们是糖原合成酶激酶-3β的抑制剂,包含它们的制药组合物,使用它们的方法和制备这些化合物的方法。
  • 3-INDOLYL-4-PHENYL-1H-PYRROLE-2,5-DIONE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3BETA
    申请人:F. Hoffmann-La Roche AG
    公开号:EP1307447B1
    公开(公告)日:2004-12-15
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