2-butoxy-1,4-butanediol | 63842-86-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-butoxy-1,4-butanediol
• 英文别名: 2-Butoxybutane-1,4-diol
• CAS: 63842-86-4
• 化学式: C₈H₁₈O₃
• 分子量: 162.229
• InChiKey: ZFHCNZMNMKSHLF-UHFFFAOYSA-N

物化性质

• 沸点：
  285.7±20.0 °C(Predicted)
• 密度：
  0.999±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-butoxy-1,4-butanediol 在 copper chromite 氢气 作用下， 生成 1,4-丁二醇
  参考文献：
  名称：

  Production of 1,4-butanediol

  摘要：

  揭示了一种改进的生产1,4-丁二醇的工艺，其中将含有二烷基烷氧基琥珀酸酯的混合物在铜铬催化剂存在下与氢气在高温高压下接触，形成包含1,4-丁二醇和相应烷醇的混合物。在一种首选实施方式中，二丁基丁氧基琥珀酸酯被转化为1,4-丁二醇和正丁醇，且选择性高。

  公开号：

  US04172961A1
• 作为产物：
  描述：

  butoxy-succinic acid dibutyl ester 、 氢化铝锂 生成 2-butoxy-1,4-butanediol
  参考文献：
  名称：

  ISHII, YOUICHI;OSAKADA, KOHTARO;IKARIYA, TAKAO;SABURI, MASAHIKO;YOSHIKAWA+, J. ORG. CHEM., 1986, 51, N 11, 2034-2039

  摘要：

  DOI：

文献信息

• Medical device with coating that promotes endothelial cell adherence
  申请人：——

  公开号：US20020049495A1

  公开（公告）日：2002-04-25

  This invention provides compositions and methods for producing a medical device coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fullerenes. The fullerenes range from about C60 to about C100. The medical device may be a stent or a synthetic graft. The antibodies promote adherence of endothelial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies. Methods of preparing such composition and methods of treating a mammal with atherosclerosis or other types of vessel obstruction are disclosed. By facilitating adherence of endothelial cells to the surface of the medical device, the methods and compositions of this invention will decrease the incidence of restenosis as well as other thromboembolic complications resulting from implantation of medical devices.

  本发明提供了生产涂有基质和与内皮细胞抗原反应的抗体的医疗器械的组合物和方法。包覆医疗器械的基质可由合成材料组成，如聚氨酯、聚左旋乳酸、纤维素酯或聚乙二醇。在另一个实施方案中，基质由天然材料组成，如胶原蛋白、纤维蛋白、弹性蛋白、无定形碳。在第三个实施方案中，基质可由富勒烯组成。富勒烯的范围从约 C60 到约 C100。医疗设备可以是支架或合成移植物。抗体可促进内皮细胞附着在医疗设备上。抗体可与基质混合，或通过连接分子与基质共价连接。粘附到医疗设备后，内皮细胞会在医疗设备上分化和增殖。抗体可以是不同类型的单克隆抗体。本文公开了制备这种组合物的方法以及治疗患有动脉粥样硬化或其他类型血管阻塞的哺乳动物的方法。通过促进内皮细胞附着在医疗器械表面，本发明的方法和组合物将降低再狭窄的发生率以及因植入医疗器械而引起的其他血栓栓塞并发症。
• Ruthenium complex catalyzed regioselective dehydrogenation of unsymmetrical .alpha.,.omega.-diols
  作者：Youichi Ishii、Kohtaro Osakada、Takao Ikariya、Masahiko Saburi、Sadao Yoshikawa

  DOI：10.1021/jo00361a018

  日期：1986.5
• COATING WHICH PROMOTES ENDOTHELIAL CELL ADHERENCE
  申请人：OrbusNeich Medical, Inc.

  公开号：EP1263484B1

  公开（公告）日：2007-05-16
• Medical Device with Coating that Promotes Endothelial Cell Adherence
  申请人：Kutryk John Bradley Michael

  公开号：US20070156232A1

  公开（公告）日：2007-07-05

  This invention provides compositions and methods for producing a medical device coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fillerenes. The fullerenes range from about C60 to about C100. The medical device may be a stent or a synthetic graft. The antibodies promote adherence of eadothelial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies. Methods of preparing such composition and methods of treating a mammal with atherosclerosis or other types of vessel obstruction are disclosed. By facilitating adherence of endothelial cells to the surface of the medical device, the methods and compositions of this invention will decrease the incidence of restenosis as well as other thromboembolic complications resulting from implantation of medical devices.
• MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE
  申请人：Kutryk Michael John Bradley

  公开号：US20130035755A1

  公开（公告）日：2013-02-07

  The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.