2-氨基喹唑啉 | 1687-51-0

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2-氨基喹唑啉
• 中文别名: 2-氨基奎唑啉
• 英文名称: quinazolin-2-ylamine
• 英文别名: 2-aminoquinazoline；2-Amino-chinazolin；quinazolin-2-amine
• CAS: 1687-51-0
• 化学式: C₈H₇N₃
• 分子量: 145.164
• InChiKey: CZAAKPFIWJXPQT-UHFFFAOYSA-N

物化性质

• 熔点：
  204 °C
• 沸点：
  370.7±25.0 °C(Predicted)
• 密度：
  1.292±0.06 g/cm3(Predicted)
• 保留指数：
  1748

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335
• 储存条件：
  2-8°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Aminoquinazoline
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H302: Harmful if swallowed
H319: Causes serious eye irritation
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Aminoquinazoline
CAS number: 1687-51-0

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
Eye contact:
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels, refrigerated.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C8H7N3
Molecular weight: 145.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氨基喹唑啉 生成 2-Ethoxycarbonylaminochinazolin
  参考文献：
  名称：

  SASSE K., SYNTHESIS, 1978, NO 5, 379-382

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯喹唑啉 在 盐酸 、 sodium azide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 2-氨基喹唑啉
  参考文献：
  名称：

  硝基，Diradicals和Ylides。2-喹唑基腈的开环扩环和开环

  摘要：

  在200°C和更高的温度下升华，将Tetrazolo [1,5- a ]喹唑啉（9）转化为2-azidoquinquinazoline（10），叠氮化物-四唑平衡受熵控制。2-喹唑基氮烯11和27和/或它们的扩环产物14和29可以经历I型（ylidic）和II型（diradicaloidoid）开环。的氩气矩阵光解9 / 10，得到2- quinazolylnitrene（11），它的特点是ESR，UV和IR光谱。还观察到由重排或开环形成的少量第二氮烯。激进主义者（19）通过II型开环快速形成并通过ESR光谱表征; 它在15 K时热衰减，半衰期约为。47分钟，与其计算得出的系统间易穿越性（19T → 19OSS）相一致，然后轻松进行环化/重排成1-氰基吲唑（21）（计算出的活化屏障1-2 kcal / mol）和N-氰基蒽腈（22）。21和22是光解的最终产物。21也是闪蒸真空热解的最终产品。零场分裂参数D（cm

  DOI：

  10.1021/jo052541i
• 作为试剂：
  描述：

  氯喳味唑酮 、 hydrochloride dihydrate salt 、 ethyl N-(6-amino-2,3-dichlorobenzyl)glycine 、 溴化氰 在 2-氨基喹唑啉 作用下， 以 alcohol 为溶剂， 生成 2-氨基喹唑啉
  参考文献：
  名称：

  Method for the manufacture of Anagrelide

  摘要：

  提供了从2,3-二氯苯甲醛制备Anagrelide碱的方法。还提供了一种从2,3-二氯苯甲醛制备中间化合物乙基N-(2,3-二氯-6-硝基苯基)甘氨酸的方法，并使用SnCl2或特定定义的催化剂还原甘氨酸化合物。进一步提供了从相应的亚胺喹唑啉化合物进行环化反应形成Anagrelide碱的方法。

  公开号：

  US20030060630A1

文献信息

• [EN] THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE<br/>[FR] DÉRIVÉS DE THIOPHÈNE POUR LE TRAITEMENT DE TROUBLES PROVOQUÉS PAR IGE
  申请人：UCB BIOPHARMA SRL

  公开号：WO2019243550A1

  公开（公告）日：2019-12-26

  Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

  提供了公式（I）的噻吩衍生物及其药用可接受的盐。这些化合物对于治疗或预防由IgE引起的疾病具有用途，如过敏、1型超敏反应或家族性鼻窦炎。
• Aminoquinazolines and their use as medicaments
  申请人：——

  公开号：US20020049197A1

  公开（公告）日：2002-04-25

  Compounds of the formula 1 having an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and air-ways, and the preparation thereof

  具有抑制酪氨酸激酶介导的信号传导作用的化合物的公式，它们在治疗疾病，特别是肿瘤性疾病和肺部及呼吸道疾病中的用途，以及其制备
• Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
  申请人：——

  公开号：US20020082271A1

  公开（公告）日：2002-06-27

  Compounds of the formula 1 having an inhibitory effect on signal transduction mediated by tyrosine kinases and their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and airways, and the preparation thereof.

  具有抑制酪氨酸激酶介导的信号转导作用的化合物的公式1，以及其在治疗疾病，特别是肿瘤性疾病和肺部及气道疾病中的用途，以及其制备方法。
• SUBSTITUTED SULFONAMIDE COMPOUNDS
  申请人：OBERBOERSCH Stefan

  公开号：US20080153843A1

  公开（公告）日：2008-06-26

  Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

  磺胺取代物，其制备方法，含有这些化合物的药物组合物，以及磺胺取代物在治疗或抑制疼痛和/或各种疾病或疾病状态中的用途。
• [DE] HETEROZYKLISCH SUBSTITUIERTE PENTANOL-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ENTZÜNDUNGSHEMMER<br/>[EN] HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS<br/>[FR] DERIVES DE PENTANOL SUBSTITUES PAR UN HETEROCYCLE, PROCEDE DE PRODUCTION DE CES COMPOSES ET LEUR UTILISATION COMME AGENTS ANTI-INFLAMMATOIRES
  申请人：SCHERING AG

  公开号：WO2005003098A1

  公开（公告）日：2005-01-13

  Die Erfindung betrifft durch Chinazolin, Chinoxalin, Cinnolin, Indazol, Phthalazin, Naphthyridin, Benzothiazol, Dihydroindolon, Dihydroisoindolon, Benzimidazol oder Indol substituierte Pentanolderivate der allgemeinen Formel (I) ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer.

  这项发明涉及一种通式（I）中由咪唑啉、喹啉、喹啉、吲唑、邻苯二酰嗪、萘啉、苯并噻唑、二氢吲哚酮、二氢异吲哚酮、苯并咪唑或吲哚取代的戊醇衍生物，以及它们的制备方法和作为抗炎药的用途。

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