3-(4-methoxypyridin-2-yl) propionic acid | 608880-87-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4-methoxypyridin-2-yl) propionic acid
• 英文别名: 3-(4-methoxypyridin-2-yl)propionic acid；4-methoxy-2-Pyridinepropanoic acid；3-(4-methoxypyridin-2-yl)propanoic acid
• CAS: 608880-87-1
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: IZGQSDZAESMUQU-UHFFFAOYSA-N

物化性质

• 沸点：
  330.9±27.0 °C(Predicted)
• 密度：
  1.203±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-methoxypyridin-2-yl) propionic acid 、 2-氨基-5-碘-3-吡啶胺 以 H₂PO₄ 为溶剂， 反应 22.0h， 生成 2-[2-(4-methoxypyridin-2-yl)ethyl]-6-iodo-3H-imidazo[4,5-b]pyridine
  参考文献：
  名称：

  [EN] IMIDAZOPYRIDINE-DERIVATIVES AS INDUCIBLE NO-SYNTHASE INHIBITORS
  [FR] DERIVES IMIDAZOPYRIDINE SERVANT D'INHIBITEURS DE NO-SYNTHASE INDUCTIBLE

  摘要：

  式（I）中R1、R2、R3、R4、R5和A的化合物具有描述中给出的含义，是新颖有效的iNOS抑制剂。

  公开号：

  WO2005030770A1
• 作为产物：
  描述：

  4-甲氧基吡啶-2-醛 在 哌啶 、 palladium 10% on activated carbon 、 氢气 、 吡啶盐酸盐 、 sodium hydroxide 作用下， 以 四氢呋喃 、 吡啶 、 甲醇 为溶剂， 反应 2.0h， 生成 3-(4-methoxypyridin-2-yl) propionic acid
  参考文献：
  名称：

  Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights

  摘要：

  Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.073

文献信息

• Novel Tetrahydropyridothiophenes
  申请人：Pekari Klaus

  公开号：US20080260749A1

  公开（公告）日：2008-10-23

  Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

  具有某种化学式（I）的化合物，在其中Ra和Rb具有描述中指示的含义，是具有抗增殖和诱导凋亡活性的新型有效化合物。
• [EN] IMIDAZO[4,5-B]QUINOLINE-DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS<br/>[FR] DERIVES DE IMIDAZO[4,5-B]QUINOLINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE NO-SYNTHASE
  申请人：ALTANA PHARMA AG

  公开号：WO2004076451A1

  公开（公告）日：2004-09-10

  The compounds of formula I In which R1, R2, R3 and A have the meanings as given In the description are novel effective INOS Inhibitors.

  式I中的化合物，其中R1、R2、R3和A的含义如描述中所述，是新颖有效的iNOS抑制剂。
• [EN] IMIDAZOPYRIDINE-DERIVATIVES AS INDUCIBLE NO-SYNTHASE INHIBITORS<br/>[FR] DERIVES IMIDAZOPYRIDINE SERVANT D'INHIBITEURS DE NO-SYNTHASE INDUCTIBLE
  申请人：ALTANA PHARMA AG

  公开号：WO2005030770A1

  公开（公告）日：2005-04-07

  The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.

  式（I）中R1、R2、R3、R4、R5和A的化合物具有描述中给出的含义，是新颖有效的iNOS抑制剂。
• [EN] IMIDAZOPYRIDINE-DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS<br/>[FR] DERIVES IMIDAZOPYRIDINE SERVANT D'INHIBITEURS DE NO-SYNTHASE INDUCTIBLE
  申请人：ALTANA PHARMA AG

  公开号：WO2005030771A1

  公开（公告）日：2005-04-07

  The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.

  式（I）中R1、R2、R3、R4、R5和A具有描述中给出的含义的化合物是新颖有效的iNOS抑制剂。
• [EN] NOVEL ALKOXYPYRIDINE-DERIVATIVES<br/>[FR] NOUVEAUX DERIVES D'ALCOXYPYRIDINE
  申请人：ALTANA PHARMA AG

  公开号：WO2003080607A1

  公开（公告）日：2003-10-02

  The compounds of formula (I) in which R1 is 1-4C-alkoxy, , A is 1-4C-alkylene, B represents 3H-imidazo (4,5b) pyridin-2-yl, 3H-imidazo (4,5-b) pyridin-2-yl substituted by R2 and/or R8, 9H-purin-8yl or 9H-purin-8-yl substituted by R4 and/or R5 are effective iNOS inhibitors.

  化学式为(I)的化合物，其中R1为1-4C-烷氧基，A为1-4C-烷基，B代表3H-咪唑并[4,5-b]吡啶-2-基，3H-咪唑并[4,5-b]吡啶-2-基被R2和/或R8取代，9H-嘌呤-8-基或9H-嘌呤-8-基被R4和/或R5取代，具有有效的iNOS抑制剂作用。