2-氯十二烷酸 | 35300-93-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-氯十二烷酸
• 英文名称: α-Chlor-dodecansaeure
• 英文别名: α-Chlorlaurinsaeure；2-chlorododecanoic acid；alpha-chlorolauric acid；2-Chlor-dodecansaeure；2-Chlor-laurinsaeure
• CAS: 35300-93-7
• 化学式: C₁₂H₂₃ClO₂
• 分子量: 234.766
• InChiKey: VMDJHUIQKPMKOC-UHFFFAOYSA-N

物化性质

• 熔点：
  35-38 °C
• 沸点：
  183-184 °C(Press: 10 Torr)
• 密度：
  1.007±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氯十二烷酸 在 双氧水 作用下， 以79%的产率得到2-Chloro-dodecaneperoxoic acid
  参考文献：
  名称：

  过酸反应的亲核研究人员

  摘要：

  过酸RC0 3H产生自由基R'，其与过酸或与溶剂反应，得到醇ROH和烃RH。自由基的亲核特性可以通过用感应基团取代带有奇数电子的碳或通过使用环状或双环自由基等封闭结构来改变自由基杂化来进行修饰。对于每个R，比率ROH / RH的测量建立了具有过酸OO键的R的反应性规模。这种反应性不依赖于自由基的稳定性，而是强烈依赖于亲核特性。一级自由基的反应性比二级自由基的要低，并且与叔级自由基的反应性要低得多。作为双环[2.2.1]庚基-1的桥头自由基不与过酸反应。这些结果被解释为表明带有电荷转移的过渡态（极性效应），过酸是亲电子的，自由基是亲核的。讨论了PMO理论。

  DOI：

  10.1016/0040-4020(80)80056-1
• 作为产物：
  描述：

  癸基丙二酸 在 磺酰氯 、 乙醚 作用下， 生成 2-氯十二烷酸
  参考文献：
  名称：

  Horn et al., Journal of the Chemical Society, 1950, p. 2900

  摘要：

  DOI：

文献信息

• Spicamycin derivatives and their use as anticancer agents
  申请人：Kirin Beer Kabushiki Kaisha

  公开号：US05461036A1

  公开（公告）日：1995-10-24

  Spicamycin derivative represented by the formula (I) or a salt thereof: ##STR1## wherein R represents specific diverse substituents, for example, a linear alkadienyl having from 11 to 13 carbon atoms, and R.sub.1 and R.sub.2 respectively represent H or OH. Examples of specific compounds are 6-[4'-N-(N'-trans,trans 2,4-tridecadienoylglycyl)spicaminyl-amino]purine, and 6-[4'-N-(N'-trans,trans-2,4 dodecadienyoly glycyl) spicaminyl-amino]purine. Comopunds according to this invention are useful as a pharmaceutical for inhibition of a tumor, for example, human colon cancer.

  公式（I）代表的Spicamycin衍生物或其盐：其中R代表特定的不同取代基，例如，具有11至13个碳原子的直链烯基，而R.sub.1和R.sub.2分别代表H或OH。具体化合物的示例是6-[4'-N-(N'-反式、反式2,4-十三碳二烯酰基甘氨酸)孢菌素基氨基]嘌呤，以及6-[4'-N-(N'-反式、反式-2,4-十二碳烯基甘氨酸)孢菌素基氨基]嘌呤。根据本发明的化合物可用作抑制肿瘤的药物，例如，人类结肠癌。
• Polyol esters of alpha-hydroxy carboxylic acids
  申请人：The Procter & Gamble Company

  公开号：US04469635A1

  公开（公告）日：1984-09-04

  Polyol esters of alpha-hydroxy carboxylic acids are disclosed which are excellent oil-in-water emulsifiers for food products, drug delivery vehicles, cosmetic ointments and the like. The compounds are also useful as detergent surfactants and can be combined with cosurfactants, builders and detergent adjunct materials.

  本文介绍了一种α-羟基羧酸的聚醇酯，它们是食品产品、药物传递载体、化妆品软膏等优秀的油水乳化剂。这些化合物还可用作洗涤剂表面活性剂，并可与共表面活性剂、建筑剂和洗涤剂辅助材料结合使用。
• Composition for controlling lipase catalyzed reactions
  申请人：Nestec S.A.

  公开号：EP2044930A1

  公开（公告）日：2009-04-08

  The present invention relates to the field of lipolysis mediated by lipases. In particular the present invention relates to the modulation of lipase activity by regulation of the composition of the interface between a hydrophobic and a hydrophilic phase. More particularly the present invention relates to a the use of a formulation comprising at least one surfactant with an interfacial pressure that is sufficiently high to control the access of lipase substrates to the interface between a lipophilic phase and a hydrophilic phase to regulate lipolysis and to a composition comprising at least one oil and enriched with at least one surfactant wherein the surfactant is non-cleavable by at least one lipase, has a higher affinity to the interface between the hydrophilic and lipophilic phase than the at least one lipid and is present in a weight ratio to the at least one lipid of about 1:1000 - 100:1.

  本发明涉及由脂肪酶介导的脂肪分解领域。特别地，本发明涉及通过调节疏水相和亲水相之间界面的组成来调节脂肪酶活性的调节。更具体地，本发明涉及使用至少一种表面活性剂组成的配方，该表面活性剂的界面压力足够高，以控制脂肪酶底物对脂肪亲相相和亲水相之间界面的接触，以调节脂肪分解，以及一种至少包含一种油并富含至少一种表面活性剂的组合物，其中表面活性剂至少不被一种脂肪酶水解，与至少一种脂类相比，在亲水相和脂肪亲相相之间的界面上具有更高的亲和力，并且在至少一种脂肪酸的重量比下存在于大约1:1000-100:1的范围内。
• Polyol esters of alpha-hydroxy carboxylic acids and compositions containing them
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0034858A2

  公开（公告）日：1981-09-02

  Polyol esters of alpha-hydroxy carboxylic acids are disclosed which are excellent oil-in-water emulsifiers for food products, drug delivery vehicles, cosmetic ointments and the like. The compounds are also useful as detergent surfactants and can be combined with cosurfactants, builders and detergent adjunct materials.

  本发明公开了α-羟基羧酸多元醇酯，它们是用于食品、给药载体、化妆品软膏等的极好的水包油型乳化剂。 这些化合物还可用作洗涤剂表面活性剂，并可与助表面活性剂、增效剂和洗涤剂辅助材料结合使用。
• Alphaphoshato amide compounds and lubricant and hydrocarbon fuel compositions containing them
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0083123A1

  公开（公告）日：1983-07-06

  Alpha-phosphato amides useful as antiwear additives for lubricants and liquid hydrocarbon fuels are disclosed. Alpha-dithiophosphato amides and alpha-thiophosphato amides containing sulfur at the alpha position are also useful as extreme pressure additives. Non-sulfur containing alpha phosphato amides and alpha-thiophosphato amides containing oxygen at the alpha position are also useful as friction-reducing additives. The compounds are non-corrosive and effective at relatively low concentrations when compared with common phosphorus-based additives.

  本发明公开了可用作润滑油和液态烃燃料抗磨添加剂的α-磷酰胺。α-位含硫的α-二硫代磷酸酰胺和α-硫代磷酸酰胺也可用作极压添加剂。不含硫的α-磷酰胺和α-硫代磷酰胺在α位含氧，也可用作减摩添加剂。与常见的磷基添加剂相比，这些化合物无腐蚀性，浓度相对较低时也有效。