methyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate | 1119581-71-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate
• 英文别名: Methyl 2-(7-chloro-5,8-dioxoquinolin-6-yl)-2-cyanoacetate；methyl 2-(7-chloro-5,8-dioxoquinolin-6-yl)-2-cyanoacetate
• CAS: 1119581-71-3
• 化学式: C₁₃H₇ClN₂O₄
• 分子量: 290.663
• InChiKey: JPZMDWJRMQPGTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  97.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate 、 甲氧苯胺 以 乙醇 为溶剂， 反应 5.0h， 生成 Methyl 2-amino-1-(4-methoxyphenyl)-4,9-dioxo-pyrrolo[3,2-g]quinoline-3-carboxylate
  参考文献：
  名称：

  Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles

  摘要：

  1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.131
• 作为产物：
  描述：

  6,7-二氯-5,8-喹啉二酮 、 氰乙酸甲酯 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.17h， 生成 methyl 2-(7-chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate
  参考文献：
  名称：

  Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles

  摘要：

  1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.131

文献信息

• Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles
  作者：Chung-Kyu Ryu、Jung Yoon Lee、Seong Hee Jeong、Ji-Hee Nho

  DOI：10.1016/j.bmcl.2008.10.131

  日期：2009.1

  1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents. (C) 2008 Elsevier Ltd. All rights reserved.