1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-imidazole | 195304-84-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-imidazole
• 英文别名: 1-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]imidazole
• CAS: 195304-84-8
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: CCDVNDSSFXXPFA-UHFFFAOYSA-N

物化性质

• 沸点：
  314.2±17.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙酮缩甘油 以 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 121.0h， 生成 1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-imidazole
  参考文献：
  名称：

  Synthesis, antifungal activity and structure-activity relationships of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)-1, 3-dioxolanes

  摘要：

  A series of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)-1,3-dioxolanes Ia-u was synthesized and tested in vitro against pathogenic fungi in man, animals and plants: Candida albicans, Aspergillus flavus and Fusarium solani. Compounds Iq-t with two polyazol groups have an in vitro activity against these fungi with MIC (minimum inhibitory concentration) value of 5 mu g mL(-1).

  DOI：

  10.1016/s0223-5234(97)83290-4

文献信息

• Cationic Lipids and Uses Thereof
  申请人：Dande Prasad A.

  公开号：US20090263407A1

  公开（公告）日：2009-10-22

  Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

  阳离子脂质、基于阳离子脂质的药物传递系统、制备它们的方法以及利用它们治疗疾病的方法被披露。
• Basic compound, resist composition and patterning process
  申请人：——

  公开号：US20040234884A1

  公开（公告）日：2004-11-25

  Resist compositions comprising basic compounds having an imidazole skeleton and a polar functional group have an excellent resolution and an excellent focus margin and are useful in microfabrication using electron beams or deep-UV light.

  包含咪唑骨架和极性官能团的碱性化合物的抗蚀组合物具有优异的分辨率和优异的聚焦余量，并且适用于使用电子束或深紫外光进行微型加工。
• CATIONIC LIPIDS AND USES THEREOF
  申请人：Dande Prasad A.

  公开号：US20100104629A1

  公开（公告）日：2010-04-29

  Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

  本发明揭示了阳离子脂质、基于阳离子脂质的药物传递系统、制备它们的方法以及使用它们治疗疾病的方法。
• US7141351B2
  申请人：——

  公开号：US7141351B2

  公开（公告）日：2006-11-28
• Synthesis, antifungal activity and structure-activity relationships of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)-1, 3-dioxolanes
  作者：H Baji、Tan Kimny、F Gasquez、M Flammang、P.L. Compagnon、A Delcourt、G Mathieu、B Viossat、G Morgant、D Nguyen-Huy

  DOI：10.1016/s0223-5234(97)83290-4

  日期：1997.7

  A series of 2-(alkyl or aryl)-2-(alkyl or polyazol-1-ylmethyl)-4-(polyazol-1-ylmethyl)-1,3-dioxolanes Ia-u was synthesized and tested in vitro against pathogenic fungi in man, animals and plants: Candida albicans, Aspergillus flavus and Fusarium solani. Compounds Iq-t with two polyazol groups have an in vitro activity against these fungi with MIC (minimum inhibitory concentration) value of 5 mu g mL(-1).