2-(N,N-dimethylamino)dimethylphosphinoethane | 154781-52-9

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(N,N-dimethylamino)dimethylphosphinoethane
• 英文别名: Ethanamine, 2-(dimethylphosphino)-N,N-dimethyl-(9CI)；2-dimethylphosphanyl-N,N-dimethylethanamine
• CAS: 154781-52-9
• 化学式: C₆H₁₆NP
• 分子量: 133.173
• InChiKey: MUOQGMMQUSHAOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(N,N-dimethylamino)dimethylphosphinoethane 在 sulfur 作用下， 以 四氢呋喃 为溶剂， 生成 N-(2'-dimethylphosphinothioylethyl)dimethylamine
  参考文献：
  名称：

  Synthesis of bidentate mixed donor phosphorus/nitrogen ligands

  摘要：

  3-(N,N-Dimethylamino)-1-(dimethylphosphino)propane was synthesised by the photochemical addition of one equivalent of dimethylphosphine to N,N-dimethylallylamine. Synthesis of 2-(N,N-dimethylamino)dimethylphosphinoethane was achieved by the reaction of tetramethyldiphosphine with N,N-dimethyl-2-chloroethylamine.

  DOI：

  10.1016/s0040-4039(00)79978-3
• 作为产物：
  描述：

  N-(2'-dimethylphosphinothioylethyl)dimethylamine 在 lithium aluminium tetrahydride 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-(N,N-dimethylamino)dimethylphosphinoethane
  参考文献：
  名称：

  Nucleophilic addition to dimethylvinylphosphine sulfide as a convenient route to polydentate ligands containing the 2-dimethylphosphinoethyl unit

  摘要：

  The synthesis of a range of new phosphine-containing polydentate ligands has been achieved by addition of sulfur and nitrogen nucleophiles to dimethylvinylphosphine sulfide, followed by reduction of the resulting phosphine sulfides with lithium aluminium hydride. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.012

文献信息

• [EN] GOLD COMPOUNDS AND THEIR USE IN THERAPY<br/>[FR] COMPOSÉS D'OR ET LEUR UTILISATION DANS LE CADRE D'UNE THÉRAPIE
  申请人：AUSPHERIX LTD

  公开号：WO2018220171A1

  公开（公告）日：2018-12-06

  Compound of formula (I) and pharmaceutically acceptable salts and solvates thereof are described, wherein: Px selected from (P1), (P2) or (P3); The compounds are useful in the prevention or treatment of a bacterial infection.

  描述了化合物的公式（I）及其药用可接受的盐和溶剂化合物，其中：Px选自（P1）、（P2）或（P3）；这些化合物在预防或治疗细菌感染方面是有用的。
• Preparation of a,B-Ethylenically Unsaturated Carboxylic Salts By Catalytic Carboxylation Of Alkenes
  申请人：BASF SE

  公开号：US20130172616A1

  公开（公告）日：2013-07-04

  In a process for preparing an alkali metal or alkaline earth metal salt of an α,β-ethylenically unsaturated carboxylic acid, a) a transition metal-alkene complex is reacted with CO 2 to give a metallalactone, b) the metallalactone is reacted with a base to give an adduct of the alkali metal or alkaline earth metal salt of the α,β-ethylenically unsaturated carboxylic acid with the transition metal complex, and c) the adduct is reacted with an alkene to release the alkali metal or alkaline earth metal salt of the α,β-ethylenically unsaturated carboxylic acid and regenerate the transition metal-alkene complex. The base is selected from alkali metal or alkaline earth metal hydroxides and alkali metal or alkaline earth metal superbases. The alkene is, for example, ethene. The transition metal complex comprises, for example, nickel and a bidentate P,P, P,N, P,O or P,carbene ligand, such as 1,2-bis(di-tert-butylphosphino)ethane.

  在制备α，β-乙烯基不饱和羧酸的碱金属或碱土金属盐的过程中，a) 过渡金属-烯烃配合物与CO2反应形成金属内酯，b) 金属内酯与碱反应形成α，β-乙烯基不饱和羧酸的碱金属或碱土金属盐与过渡金属配合物的加合物，c) 加合物与烯烃反应释放出α，β-乙烯基不饱和羧酸的碱金属或碱土金属盐，并再生过渡金属-烯烃配合物。碱为选自碱金属或碱土金属的氢氧化物和碱金属或碱土金属的超碱。烯烃可以是乙烯等。过渡金属配合物包括镍和双齿P，P，P，N，P，O或P，卡宾配体，例如1,2-双(二叔丁基膦基)乙烷。
• Preparation and Characterization of Nickel(II), Palladium(II), and Platinum(II) Complexes Containing (2-Aminoethyl)dimethylphosphine or the Related Didentate Phosphine Ligands
  作者：Takayoshi Suzuki、Akira Morikawa、Kazuo Kashiwabara

  DOI：10.1246/bcsj.69.2539

  日期：1996.9

  determined by NMR spectroscopy. All the palladium(II) complexes prepared in this study are cis-isomers, in contrast to the analogous Me2PCH2CH2S− (dmsp) complex (trans-[Pd(dmsp)2]), which indicates that the anionic phosphine-thiolate ligand prefers the trans geometry more than the neutral phosphine-amine or -thioether ligand does. The dichloride salts of the bis(edmp) complexes, cis-[M(edmp)2]Cl2 (M = Ni (4a)

  这里描述了几种新的双（螯合）型镍 (II)、钯 (II) 和铂 (II) 配合物，双齿膦配体具有氨基或硫醚供体基团：Me2PCH2CH2NH2 (edmp)、Ph2PCH2CH2NH2 (edpp)、 Me2PCH2CH2NMe2 (dmedmp) 或 Me2PCH2CH2SMe (mtdmp)。[M(P-N or S)2]2+ (M = Ni, Pd, and Pt; (P-N or S) = 上述配体）的双（四氟硼酸盐）盐已制备，几何结构由下式确定核磁共振光谱。本研究中制备的所有钯 (II) 配合物都是顺式异构体，与类似的 Me2PCH2CH2S− (dmsp) 配合物（反式-[Pd(dmsp)2]）相反，这表明阴离子膦硫醇配体更喜欢反式几何比中性膦胺或硫醚配体多。双 (edmp) 络合物的二氯化盐，顺式-[M(edmp)2]Cl2 (M = Ni (4a), Pd(5a),
• [EN] PREPARING AN UNSATURATED CARBOXYLIC ACID SALT FROM AN ALKENE AND CARBON DIOXIDE USING A HETEROGENEOUS BASE<br/>[FR] PRÉPARATION D'UN SEL D'ACIDE CARBOXYLIQUE INSATURÉ À PARTIR D'UN ALCÈNE ET DE DIOXYDE DE CARBONE À L'AIDE D'UNE BASE HÉTÉROGÈNE
  申请人：BASF SE

  公开号：WO2015173296A1

  公开（公告）日：2015-11-19

  Process for preparing an α,β-ethylenically unsaturated carboxylic acid salt, comprising, reacting an alkene and carbon dioxide in the presence of a carboxylation catalyst to obtain a catalyst-coordinated carboxylated intermediate, treating the catalyst- coordinated carboxylated intermediate with a heterogeneous base, and releasing the α,β-ethylenically unsaturated carboxylic acid salt, wherein the heterogeneous base comprises an organic basic moiety that is immobilized on a solid support. The process avoids accumulation of the conjugate acid of the base in the reaction medium.

  制备α，β-乙烯基不饱和羧酸盐的过程包括，在羧化催化剂存在下，使烯烃和二氧化碳反应，得到一个催化剂协同的羧化中间体；用异相碱处理催化剂协同的羧化中间体，释放α，β-乙烯基不饱和羧酸盐。其中，异相碱包括有机碱基固定在固体支撑上的基团。该过程避免了反应介质中碱的共轭酸的积累。
• [EN] PROCESS FOR PREPARING AN UNSATURATED CARBOXYLIC ACID SALT<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN SEL D'ACIDE CARBOXYLIQUE INSATURÉ
  申请人：BASF SE

  公开号：WO2017178282A1

  公开（公告）日：2017-10-19

  The present invention relates to a catalytic process for preparing an α,β-ethylenically unsaturated carboxylic acid salt, comprising contacting an alkene and carbon dioxide with a carboxylation catalyst being a transition metal complex, an alkoxide, and an organic solvent, to obtain an α,β-ethylenically unsaturated carboxylic acid salt, the organic solvent being incompletely miscible with water at a pressure of 1 bar at at least one temperature T and selected from amides and ureas, T being a temperature in the range from 10°C to 90°C.

  本发明涉及一种催化制备α，β-乙烯基不饱和羧酸盐的过程，包括将烯烃和二氧化碳与羧化催化剂接触，该催化剂为过渡金属配合物、醇盐和有机溶剂，以获得α，β-乙烯基不饱和羧酸盐，所述有机溶剂在至少一温度T下在1巴压力下与水不完全混溶，所述有机溶剂选自酰胺和脲，T为10℃至90℃范围内的温度。