7-diethylaminomethyl-8-hydroxyquinoline | 77895-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-diethylaminomethyl-8-hydroxyquinoline
• 英文别名: 7-[(Diethylazaniumyl)methyl]quinolin-8-olate
• CAS: 77895-34-2
• 化学式: C₁₄H₁₈N₂O
• 分子量: 230.31
• InChiKey: ZDKKFSNLZTZYRN-UHFFFAOYSA-N

物化性质

• 沸点：
  362.7±27.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-diethylaminomethyl-8-hydroxyquinoline 在 palladium on activated charcoal 氢氧化钾 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 18.0h， 生成 8-methoxy-7-methyl-quinoline
  参考文献：
  名称：

  Origins of ‘on–off’ fluorescent behavior of 8-hydroxyquinoline containing chemosensors

  摘要：

  Derivatives of 8-hydroxyquinoline were used as model compounds to probe the pathways of non-radiative relaxation of fluorophores in two fluorescent chemosensors. Results suggest that both photo-induced proton transfer and photo-induced electron transfer contribute to quenching the fluorescence of the chemosensors. Crystal structures of an 8-hydroxyquinoline-containing chemosensor complexed to various metal ions indicate that a proton shift occurs concomitant with complex formation. This proton shift precludes both photo-induced proton and electron transfer allowing fluorescence emission from chemosensor-metal ion complexes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.08.062
• 作为产物：
  描述：

  8-羟基喹啉 生成 7-diethylaminomethyl-8-hydroxyquinoline
  参考文献：
  名称：

  SHIXALIEV, SH. M.;GADZHIEVA, M. A.;SHAMXALOV, R. M.;RZAEV, A. A.

  摘要：

  DOI：

文献信息

• Novel Quinoline-Hepcidine Antagonists
  申请人：Dürrenberger Franz

  公开号：US20120196853A1

  公开（公告）日：2012-08-02

  The present invention relates to novel hepcidin antagonists of the general formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

  本发明涉及一种新型的肝铁蛋白拮抗剂，其一般式为(I)，包括它们的药物组合物以及将其用作药物的用途，特别是用于治疗铁代谢紊乱的疾病，如特别是铁缺乏病和贫血，特别是与慢性炎症性疾病相关的贫血（ACD：慢性疾病贫血和AI：炎症性贫血）。
• Dibromomethane as One‐Carbon Source in Organic Synthesis: The Mannich Base Formation from the Reaction of Phenolic Compounds with a Preheated Mixture of Dibromomethane and Diethylamine
  作者：Yung‐Son Hon、Yu‐Yu Chou、I‐Che Wu

  DOI：10.1081/scc-120038509

  日期：2004.12.31

  salt formed from the reaction of dihalomomethane and diethylamine reacted with phenolic compounds to give the corresponding Mannich bases in modest to good yields. As for the relative rates and yields are in the following order: CH2Br2 > CH2Cl2. The CD2Cl2 is also applicable to prepare the deuterated analogues. At higher temperature, the elimination of diethylamine from Mannich base occurred to give the

  摘要 二卤甲烷和二乙胺反应形成的盐与酚类化合物反应生成相应的曼尼希碱，收率适中。至于相对率和收率的顺序如下：CH2Br2>CH2Cl2。CD2Cl2 也适用于制备氘代类似物。在较高温度下，二乙胺从曼尼希碱中消除，得到相应的邻醌甲基化物中间体，然后被另一种酚类化合物捕获，得到双（2-羟基-1-芳基）甲烷。
• Soliman, Fouad M.; Said, Medhat M., Zeitschrift fur Naturforschung, B: Chemical Sciences, 1991, vol. 46, # 8, p. 1105 - 1109
  作者：Soliman, Fouad M.、Said, Medhat M.

  DOI：——

  日期：——
• Chelating Properties of 8-Quinolinol Mannich Bases
  作者：J. P. Phillips、Quintus Fernando

  DOI：10.1021/ja01111a048

  日期：1953.8
• SHIXALIEV, SH. M.;GADZHIEVA, M. A.;SHAMXALOV, R. M.;RZAEV, A. A.
  作者：SHIXALIEV, SH. M.、GADZHIEVA, M. A.、SHAMXALOV, R. M.、RZAEV, A. A.

  DOI：——

  日期：——