(Z)-7-heptadecen-2-one | 1265227-06-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-7-heptadecen-2-one
• 英文别名: (Z)-heptadec-7-en-2-one
• CAS: 1265227-06-2
• 化学式: C₁₇H₃₂O
• 分子量: 252.44
• InChiKey: JSQCJGGAXMOVJV-QXMHVHEDSA-N

物化性质

• 沸点：
  358.4±21.0 °C(Predicted)
• 密度：
  0.841±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (Z)-7-heptadecen-2-one 在 10% palladium on activated carbon 、 氢气 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醇 、 正庚烷 、 乙基苯 为溶剂， 反应 25.5h， 生成 1-methyl-2-pentadecyl-4(1H)-quinolone
  参考文献：
  名称：

  Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1H)-quinolones

  摘要：

  A series of 23 new 1-methyl-2-alkenyl-4(1H)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as Mycobacterium fortuitum, M. smegmatis and M. phlei. The compounds displayed good to excellent inhibition of the growth of the mycobacterial test strains with improved antimycobacterial activity compared to the hit compound, evocarpine. The most active compounds, which possessed chain length of 11-13 carbons at position-2 displayed potent inhibitory effects with an MIC value of 1.0 mg/L. In a human diploid embryonic lung cell line, MRC-5 cytotoxicity assay, the alkaloids showed weak to moderate cytotoxic activity. Biological evaluation of these evocarpine analogues on the less pathogenic fast growing strains of mycobacteria showed an interesting antimycobacterial profile and provided significant insight into the structure-activity relationships. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.060
• 作为产物：
  描述：

  (5-羧基戊基)三苯基溴化磷 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 8.0h， 生成 (Z)-7-heptadecen-2-one
  参考文献：
  名称：

  Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1H)-quinolones

  摘要：

  A series of 23 new 1-methyl-2-alkenyl-4(1H)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as Mycobacterium fortuitum, M. smegmatis and M. phlei. The compounds displayed good to excellent inhibition of the growth of the mycobacterial test strains with improved antimycobacterial activity compared to the hit compound, evocarpine. The most active compounds, which possessed chain length of 11-13 carbons at position-2 displayed potent inhibitory effects with an MIC value of 1.0 mg/L. In a human diploid embryonic lung cell line, MRC-5 cytotoxicity assay, the alkaloids showed weak to moderate cytotoxic activity. Biological evaluation of these evocarpine analogues on the less pathogenic fast growing strains of mycobacteria showed an interesting antimycobacterial profile and provided significant insight into the structure-activity relationships. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.10.060

文献信息

• Opioid receptor antagonist prodrugs
  申请人：Nirsum Laboratories, Inc.

  公开号：US10544154B2

  公开（公告）日：2020-01-28

  Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.

  本文提供了阿片受体拮抗剂（如纳美芬和纳曲酮）的原药、包含所述化合物的药物组合物以及使用所述化合物治疗行为紊乱的方法。
• ALKOXYLATED SORBITAN ESTERS AS CRUDE OIL EMULSION BREAKERS
  申请人：Ecolab USA Inc.

  公开号：US20140213668A1

  公开（公告）日：2014-07-31

  Disclosed herein are alkoxylated sorbitan ester compounds and compositions useful in emulsion breaking applications relating to the production, transportation, storage, and separation of crude oil and natural gas. Also disclosed herein are methods of using the compounds and compositions as emulsion breakers, particularly in applications relating to the production, transportation, storage, and separation of crude oil and natural gas.
• BIOCIDE COMPOSITIONS
  申请人：Ecolab USA Inc.

  公开号：US20150038470A1

  公开（公告）日：2015-02-05

  Disclosed are biocide compositions. The compositions are useful in applications relating to the production, transportation, storage, and separation of crude oil and natural gas. Also disclosed are methods of using the compositions, particularly in applications relating to the production, transportation, storage, and separation of crude oil and natural gas.
• OPIOID RECEPTOR ANTAGONIST PRODRUGS
  申请人：Nirsum Laboratories, Inc.

  公开号：US20190308989A1

  公开（公告）日：2019-10-10

  Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders.
• GEMCITABINE PRODRUGS
  申请人：CURE BIOPHARMA INC.

  公开号：US20210323992A1

  公开（公告）日：2021-10-21

  Provided herein are phosphorylated gemcitabine derivative prodrug compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of cancer.