2-(2-chloro-6-fluoro-phenyl)-3-quinolin-2-yl-thiazolidin-4-one | 1097721-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2-chloro-6-fluoro-phenyl)-3-quinolin-2-yl-thiazolidin-4-one
• 英文别名: 2-(2-Chloro-6-fluoro-phenyl)-3-(2-quinolyl)thiazolidin-4-one；2-(2-chloro-6-fluorophenyl)-3-quinolin-2-yl-1,3-thiazolidin-4-one
• CAS: 1097721-67-9
• 化学式: C₁₈H₁₂ClFN₂OS
• 分子量: 358.823
• InChiKey: YCCHQUOMZVHIOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基喹啉 、 2-氯-6-氟-苯甲醛 、 巯基乙酸 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以56%的产率得到2-(2-chloro-6-fluoro-phenyl)-3-quinolin-2-yl-thiazolidin-4-one
  参考文献：
  名称：

  Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-Aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives

  摘要：

  Hepatitis C virus (HCV) NS5B RNA polymerase is crucial for replicating the HCV RNA genome and is an attractive target for developing anti-HCV drugs. A novel series of 2,3-diaryl-1,3-thiazolidin-4-one derivatives were evaluated for their ability to inhibit HCV NS5B. Of this series, compounds 4c, 5b, 5c and 6 emerged as more potent, displaying over 95% inhibition of NS5B RNA polymerase activity in vitro. The two most active compounds 4c and 5c exhibited an IC50 of 31.9 mu M and 32.2 mu M, respectively, against HCV NS5B. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.023

文献信息

• Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-Aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives
  作者：Ravindra K. Rawal、S.B. Katti、Neerja Kaushik-Basu、Payal Arora、Zhenhua Pan

  DOI：10.1016/j.bmcl.2008.10.023

  日期：2008.12

  Hepatitis C virus (HCV) NS5B RNA polymerase is crucial for replicating the HCV RNA genome and is an attractive target for developing anti-HCV drugs. A novel series of 2,3-diaryl-1,3-thiazolidin-4-one derivatives were evaluated for their ability to inhibit HCV NS5B. Of this series, compounds 4c, 5b, 5c and 6 emerged as more potent, displaying over 95% inhibition of NS5B RNA polymerase activity in vitro. The two most active compounds 4c and 5c exhibited an IC50 of 31.9 mu M and 32.2 mu M, respectively, against HCV NS5B. (C) 2008 Elsevier Ltd. All rights reserved.