甘氨酸,N-[2-(4-羟基苯基)乙酰基]- | 6061-06-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 甘氨酸,N-[2-(4-羟基苯基)乙酰基]-
• 英文名称: 1,1,-dichloro-1,3-butadiene
• 英文别名: 1,1-dichlorobuta-1,3-diene
• CAS: 6061-06-9；28577-62-0
• 化学式: C₄H₄Cl₂
• 分子量: 122.982
• InChiKey: PDKAXHLOFWCWIH-UHFFFAOYSA-N

物化性质

• 沸点：
  99.04°C (estimate)
• 密度：
  1.1829 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903299090

反应信息

• 作为反应物：
  描述：

  甘氨酸,N-[2-(4-羟基苯基)乙酰基]- 、 1-氯-N,N,2-三甲基丙烯胺 在 氯化锌 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成 2,2-Dimethyl-3-(β,β-dichlorvinyl)-cyclobutanon
  参考文献：
  名称：

  Production of insecticidally active vinyl-cyclopropane carboxylic acid

  摘要：

  公式为##STR1##的杀虫活性乙烯-环丙烷羧酸酯可通过将##STR2##与R.sup.12为从##STR3##中选择的基团反应，与公式M--O--R.sup.8的醇酸盐反应制备而成。还描述了制备中间体的各种方法。许多中间体和最终产品都是新的。

  公开号：

  US04291176A1
• 作为产物：
  描述：

  1,1,1,3-四氯丁烷 生成 甘氨酸,N-[2-(4-羟基苯基)乙酰基]-
  参考文献：
  名称：

  Kooyman, Recueil des Travaux Chimiques des Pays-Bas, 1951, vol. 70, p. 684,687

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCTION OF 2,3-DICHLOROBUTADIENE-1,3
  申请人：REDWINE TERRY WAYNE

  公开号：US20090163745A1

  公开（公告）日：2009-06-25

  2,3-dichlorobutadiene-1,3 of high purity is produced from 1,2,3,4-tetrachlorobutane by a process comprising the steps of dehydrochlorination, chlorination of the reaction product obtained in the dehydrochlorination step and subsequent separation of a 2,3-dichlorobutadiene-1,3 composition from the reaction product of the chlorination step.

  高纯度的2,3-二氯丁二烯-1,3是通过从1,2,3,4-四氯丁烷中经过脱氯化、氯化脱氯化步骤得到的反应产物进行氯化，然后从氯化步骤的反应产物中分离出2,3-二氯丁二烯-1,3组成的过程来生产的。
• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF 2,3,-DICHLORO 1,3,BUTADIENE FROM 1,3 BUTADIENE<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE 2,3-DICHLORO-1,3-BUTADIÈNE À PARTIR DE 1,3-BUTADIÈNE
  申请人：PIDILITE IND LTD

  公开号：WO2011058575A1

  公开（公告）日：2011-05-19

  The present invention relates to an improved process for the production of 2,3-Dichloro 1,3-Butadiene which comprises Chlorinating Butadiene, in liquid phase, in the presence of chlorinated solvents & phase transfer catalyst, Distilling the solvent, Distilling the formed 3,4-dichlorobutene-1, 1,4-dichlorobutene-2; and 1,2,3,4-Tetrachlorbutane; under reduced pressure,chlorinating the separated 3,4-dichlorobutene-1 and 1,4-dichlorobutene-2 to give 1,2,3,4-Tetrachlorobutane.,double Dehydrochlorinating the 1,2,3,4-Tetrachlorobutane using methanol,alkali and inhibitors under atmosphere of 1% oxides of nitrogen in nitrogen atmosphere the total period of Dehydrochlorinating being in the range of 15-33 hours to give 2,3-Dichloro 1,3-Butadiene and separating methanol to get 2,3-Dichloro 1,3-Butadiene

  本发明涉及一种改进的生产2,3-二氯-1,3-丁二烯的方法，包括在液相中存在氯化溶剂和相转移催化剂的情况下氯化丁二烯，蒸馏溶剂，蒸馏形成的3,4-二氯丁烯-1，1,4-二氯丁烯-2和1,2,3,4-四氯丁烷；在减压下氯化分离的3,4-二氯丁烯-1和1,4-二氯丁烯-2以得到1,2,3,4-四氯丁烷，使用甲醇、碱和抑制剂双脱氯化1,2,3,4-四氯丁烷，在含有1%氮氧化物的氮气氛围下进行总脱氯化时间范围在15-33小时，得到2,3-二氯-1,3-丁二烯并分离甲醇以获得2,3-二氯-1,3-丁二烯。
• Preparation of cyclobutanones
  申请人：Bayer Aktiengesellschaft

  公开号：US04216172A1

  公开（公告）日：1980-08-05

  A process for the preparation of a cyclobutanone of the formula ##STR1## in which R.sup.1 to R.sup.6 each independently is a hydrogen, halogen, cyano, alkoxy, alkoxycarbonyl, carboxamido, dialkylphosphono, alkyl, cycloalkyl, aryl, aralkyl or alkenyl radical, or two of them together with the carbon atom to which each is linked form a ring, comprising reacting an N,N-disubstituted carboxylic acid amide of the formula ##STR2## in which R.sup.7 and R.sup.8 each independently is an alkyl, cycloalkyl, alkenyl, aryl or aralkyl radical or together form a ring, with an inorganic acid halide, and then reacting the product with a tertiary amine, an olefin of the formula ##STR3## and a Lewis acid, and subsequently hydrolyzing the mass. Preferably isobutyric acid dimethylamide is employed as the carboxylic acid amide, phosgene is employed as the inorganic acid halide, triethylamine is employed as the tertiary amine and zinc chloride or titanium tetrachloride is employed as the Lewis acid. The products are known intermediates for insecticides.

  一种制备分子式为##STR1##的环丁酮的方法，其中R.sup.1至R.sup.6分别独立地是氢、卤素、氰基、烷氧基、烷氧羰基、羧胺基、二烷基磷酸酯基、烷基、环烷基、芳基、芳基烷基或烯基基团，或其中的两个与其连接的碳原子形成环，包括将分子式为##STR2##的N,N-二取代羧酸酰胺与无机酸卤反应，然后将产物与三级胺、分子式为##STR3##的烯烃和路易斯酸反应，随后水解。最好使用异丁酸二甲酰胺作为羧酸酰胺，光气作为无机酸卤，三乙胺作为三级胺，氯化锌或四氯化钛作为路易斯酸。产品是杀虫剂的已知中间体。
• Process for production of 2,3-dichlorobutadiene-1,3
  申请人：REDWINE TERRY WAYNE

  公开号：US20090163746A1

  公开（公告）日：2009-06-25

  Purified chlorinated alkenes are produced by a process in which a mixture of i) a first chlorinated alkene that has at least one beta-chlorine substituent and no alpha-chlorine substituents and ii) a second chlorinated alkene that has at least one alpha-chlorine substituent is contacted with chlorine in an amount sufficient to further chlorinate the second chlorinated alkene, but which is insufficient to cause conversion of more than 20% of the first chlorinated alkene. The resultant reaction product may be easily enriched to provide a chlorinated alkene product wherein a) the weight percentage of chlorinated alkenes having at least one beta-chlorine substituent and no alpha-chlorine substituents, based on the total weight of the chlorinated alkenes present in the enriched chlorinated alkene product compared to b) the weight percentage of chlorinated alkenes having at least one beta-chlorine substituent and no alpha-chlorine substituents, based on the total weight of the chlorinated alkenes present in the mixture prior to chlorination is increased by at least 0.25 wt. %.

  经过一种方法制备纯化的氯化烯烃，其中混合物包括i）至少有一个β-氯代取代基且没有α-氯代取代基的第一氯化烯烃和ii）至少有一个α-氯代取代基的第二氯化烯烃，该混合物与氯气接触，氯气的量足以进一步氯代第二氯化烯烃，但不足以使第一氯化烯烃的转化率超过20％。所得的反应产物可以轻松富集，以提供氯化烯烃产品，其中a）基于富集的氯化烯烃产品中存在的氯化烯烃的总重量，至少有一个β-氯代取代基且没有α-氯代取代基的氯化烯烃的重量百分比，与b）基于氯化前混合物中存在的氯化烯烃的总重量，至少有一个β-氯代取代基且没有α-氯代取代基的氯化烯烃的重量百分比相比，增加了至少0.25重量％。
• Reactions of cycloalkanecarboxylic acids with SF4. II. Fluorination of gem-dichlorocyclopropanecarboxylic acids with SF4
  作者：Yu.M. Pustovit、P.I. Ogojko、V.P. Nazaretian、A.B. Rozhenko

  DOI：10.1016/0022-1139(93)02995-q

  日期：1994.12

  Treatment of gem-dichlorocyclopropanecarboxylic acids with SF4 yields many rearranged products, i.e. 1,1-difluoro-substituted olefins. The mechanism of the rearrangement is discussed.

  用SF 4处理宝石-二氯环丙烷羧酸产生许多重排产物，即1，1-二氟取代的烯烃。讨论了重排的机制。