Allyl β-D-galactofuranoside | 107691-60-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Allyl β-D-galactofuranoside
• 英文别名: 1-allyl-β-D-galactofuranoside；Prop-2-En-1-Yl Beta-D-Galactofuranoside；(2S,3R,4R,5R)-2-[(1R)-1,2-dihydroxyethyl]-5-prop-2-enoxyoxolane-3,4-diol
• CAS: 107691-60-1
• 化学式: C₉H₁₆O₆
• 分子量: 220.222
• InChiKey: ZOIPKVBHIUBYNB-GOFVFXDOSA-N

物化性质

• 沸点：
  462.7±45.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Allyl β-D-galactofuranoside 在 camphor-10-sulfonic acid sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 16.5h， 生成 Allyl 2,3-O-dibenzyl-5,6-O-isopropyliden-β-D-galactofuranoside
  参考文献：
  名称：

  Sugawara, Fumio; Nakayama, Haruhiko; Ogawa, Tomoya, Agricultural and Biological Chemistry, 1986, vol. 50, # 6, p. 1557 - 1562

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2,3,5,6-penta-O-acetyl-β-D-galactofuranose 在 三氯化铝 、 sodium methylate 、 mercury dibromide 作用下， 以 甲醇 、 氯仿 、 乙腈 为溶剂， 反应 1.0h， 生成 Allyl β-D-galactofuranoside
  参考文献：
  名称：

  Sugawara, Fumio; Nakayama, Haruhiko; Ogawa, Tomoya, Agricultural and Biological Chemistry, 1986, vol. 50, # 6, p. 1557 - 1562

  摘要：

  DOI：

文献信息

• MICROBIAL GLYCANS AS A TARGET OF HUMAN INTELECTIN
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20160131649A1

  公开（公告）日：2016-05-12

  The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including Streptococcus pneumonia, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumonia and Yersinia pestis . This interaction can be targeted to identify, purify and therapeutically target such organisms.

  本公开提供了一种诊断和治疗细菌感染的方法。已经证明人类Intelectin 1（hIntL-1）选择性地结合细菌的糖基组分，包括肺炎链球菌、奇异变形杆菌、普通变形杆菌、肺炎克雷伯菌和鼠疫耶尔森氏菌。这种相互作用可以被用来识别、纯化和治疗这些细菌。
• Microbial glycans as a target of human intelectin
  申请人：Wisconsin Alumni Research Foundation

  公开号：US10082506B2

  公开（公告）日：2018-09-25

  The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including Streptococcus pneumonia, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumonia and Yersinia pestis. This interaction can be targeted to identify, purify and therapeutically target such organisms.

  本公开提供了诊断和治疗细菌感染的方法。人类因特蛋白 1（hIntL-1）已被证明可选择性地与细菌（包括肺炎链球菌、奇异变形杆菌、普通变形杆菌、肺炎克雷伯氏菌和鼠疫耶尔森菌）上的聚糖成分结合。这种相互作用可用于识别、纯化和治疗这类生物。
• Probiotic function of human intelectin
  申请人：Wisconsin Alumni Research Foundation

  公开号：US10413588B2

  公开（公告）日：2019-09-17

  The present disclosure provides for methods providing a pre/probiotic agent to a subject. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria, thereby promoting and protecting the microbiome.

  本公开提供了向受试者提供前/生物制剂的方法。人类因特蛋白 1（hIntL-1）已被证明可选择性地与细菌上的聚糖成分结合，从而促进和保护微生物组。
• Kinetic Products Under Thermal Conditions: Rapid Entry into α/β-D-Galactofuranosides Using Microwave Irradiation and Selective Lewis Acids
  作者：Soumava Santra、Emily Jonas、Jean-Paul Bourgault、Tarick El-Baba、Peter R. Andreana

  DOI：10.1080/07328303.2011.585259

  日期：2011.1.1

  A modified Fischer-Lubineau reaction, employing microwave irradiation and selected Lewis acids such as Mn(ClO4)(2), Mn(C2H3O2)(3), FeCl3, CoCl2, and AgF as independent additives, induces rapid entry into alpha/beta-D-galactofuranosides in very good yield and purity.
• PROBIOTIC FUNCTION OF HUMAN INTELECTIN
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20170136088A1

  公开（公告）日：2017-05-18

  The present disclosure provides for methods providing a pre/probiotic agent to a subject. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria, thereby promoting and protecting the microbiome.