Benzyloxycarbonyl-L-glutamyl-L-glutaminsaeure

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Benzyloxycarbonyl-L-glutamyl-L-glutaminsaeure
• 英文别名: N-Benzyloxycarbonyl-α-L-glutamyl-L-glutaminsaeure；N-(N-benzyloxycarbonyl-L-α-glutamyl)-glutamic acid；N-(N-Benzyloxycarbonyl-L-α-glutamyl)-glutaminsaeure；N-(N-Benzyloxycarbonyl-α-L-glutamyl)-L-glutaminsaeure；(2S)-2-[[(2S)-4-carboxy-2-(phenylmethoxycarbonylamino)butanoyl]amino]pentanedioic acid
• 化学式: C₁₈H₂₂N₂O₉
• 分子量: 410.381
• InChiKey: LLURAMYWCOYECS-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  29
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  179
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  Benzyloxycarbonyl-L-glutamyl-L-glutaminsaeure 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 水 为溶剂， 生成 L-alpha-谷氨酰-L-谷氨酸
  参考文献：
  名称：

  Studies on Peptides. VIII. The Synthesis of α,γ-Glutamyl Peptides and the Cleavage Reactions of their γ-Glutamyl Peptide Linkages

  摘要：

  DOI：

  10.1246/bcsj.33.1721
• 作为产物：
  描述：

  L-谷氨酸5乙脂 在 sodium hydroxide 作用下， 生成 Benzyloxycarbonyl-L-glutamyl-L-glutaminsaeure
  参考文献：
  名称：

  Pteroic Acid Derivatives. V. Pteroyl-α-glutamyl-α-glutamylglutamic Acid, Pteroyl-γ-glutamyl-α-glutamylglutamic Acid, Pteroyl-α-glutamyl-γ-glutamylglutamic Acid

  摘要：

  DOI：

  10.1021/ja01175a012

文献信息

• Synthesis of an Enlarged Library of Dynamic DNA Activators with Oxime, Disulfide and Hydrazone Bridges
  作者：Javier Montenegro、Eun-Kyoung Bang、Naomi Sakai、Stefan Matile

  DOI：10.1002/chem.201200550

  日期：2012.8.13

  heads. Here, we report synthesis efforts to enlarge this focused library with oxime and disulfide bridges and dynamic amphiphiles with more than one positive charge. Evaluation in fluorogenic vesicles reveals best activation of DNA as ion transporters by dynamic amphiphiles with dendritic scaffolds, doubly charged heads and four tails. Moreover, oximes, contrary to hydrazones, remain active under acidic

  动态的两亲物在带电的头部和疏水的尾巴之间有一个“桥梁”。动态共价键的存在对于差异和生物传感应用以及快速访问筛选siRNA的基因传递或细胞摄取所需的文库非常重要。但是，迄今为止，开发文库的努力都集中在to与单阳离子头的连接上。在这里，我们报告了合成的努力，以扩大肟和二硫键和带有两个以上正电荷的动态两亲物的聚焦库。对荧光囊泡的评估表明，具有树突状支架，双电荷头和四尾的动态两亲分子可最佳地激活DNA作为离子转运蛋白。而且，与相反，肟在酸性条件下仍保持活性。
• Depth-sensing indentation at macroscopic dimensions
  作者：Jeremy Thurn、Dylan J. Morris、Robert F. Cook

  DOI：10.1557/jmr.2002.0388

  日期：2002.10

  A macroscopic-scale depth-sensing indentation apparatus with the ability to be mounted on an inverted microscope for in situ observation of contact events was calibrated using the Oliver and Pharr [J. Mater. Res. 7, 1564 (1992)] procedure with a two-parameter area function. The calibrated Vickers tip was used to determine the projected contact area at peak load and the modulus and hardness of a variety of non-metallic materials through deconvolution of the measured load-displacement traces. The predicted contact area was found to be identical to the measured area of residual contact impressions. Furthermore, for transparent ceramic materials the projected contact area during loading was found to be the same as the area measured from the diagonal of post-indentation residual contact impressions. The modulus and hardness values deconvoluted from the load–displacement traces were compared with independent measurements. The effects of sample clamping, column compliance, and tip radius on the load–displacement data and inferred materials properties were also examined. It is suggested that the simplicity of instrumentation and operation, combined with the ability to observe indentations optically, even in situ, makes macroscopic-scale depth-sensing indentation ideal for fundamental studies of contact mechanics.

  使用 Oliver 和 Pharr [J. Mater. Res. 7, 1564 (1992)]的双参数面积函数程序校准了可安装在倒置显微镜上现场观察接触事件的宏观尺度深度感应压痕仪。校准后的维氏针尖用于确定峰值载荷时的预计接触面积，以及通过对测量的载荷-位移轨迹进行解卷积来确定各种非金属材料的模量和硬度。结果发现，预测的接触面积与测量的残留接触印痕面积相同。此外，对于透明陶瓷材料，加载期间的预测接触面积与压痕后残留接触印痕对角线上测量的面积相同。从加载-位移轨迹中分解出的模量和硬度值与独立测量值进行了比较。此外，还研究了样品夹持、柱顺应性和顶端半径对载荷-位移数据和推断材料属性的影响。研究表明，仪器和操作的简易性，加上光学观测压痕的能力，甚至是原位观测的能力，使宏观尺度的深度感应压痕成为接触力学基础研究的理想选择。
• Bergmann; Zervas, Chemische Berichte, 1932, vol. 65, p. 1192,1198
  作者：Bergmann、Zervas

  DOI：——

  日期：——
• Klieger,E.; Gibian,H., Justus Liebigs Annalen der Chemie, 1961, vol. 649, p. 183 - 202
  作者：Klieger,E.、Gibian,H.

  DOI：——

  日期：——
• DE556798
  申请人：——

  公开号：——

  公开（公告）日：——