3,6,9,16,19,22-hexaoxa-12,13-dithiatetracosane-1,24-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6,9,16,19,22-hexaoxa-12,13-dithiatetracosane-1,24-diol
• 英文别名: 11,11'-dithio-bis[undecanyl-3,6,9-trioxa-undecan-1-ol]；Hydroxy-PEG3-SS-PEG3-alcohol；2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyldisulfanyl]ethoxy]ethoxy]ethoxy]ethanol
• 化学式: C₁₆H₃₄O₈S₂
• 分子量: 418.573
• InChiKey: LSCOQDOWFVSGMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  26
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4,4'-dithiobisbenzoic acid dichloride 、 3,6,9,16,19,22-hexaoxa-12,13-dithiatetracosane-1,24-diol 在 三乙胺 、 1,4-二巯基-2,3-丁二醇 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 2-[2-(2-(2-mercaptoethoxy)ethoxy)ethoxy]ethyl 4-mercaptobenzoate
  参考文献：
  名称：

  Oxidative folding of lysozyme with aromatic dithiols, and aliphatic and aromatic monothiols

  摘要：

  In vitro protein folding of disulfide containing proteins is aided by the addition of a redox buffer, which is composed of a small molecule disulfide and/or a small molecule thiol. In this study, we examined redox buffers containing asymmetric dithiols 1-5, which possess an aromatic and aliphatic thiol, and symmetric dithiols 6 and 7, which possess two aromatic thiols, for their ability to fold reduced lysozyme at pH 7.0 and 8.0. Most in vivo protein folding catalysts are dithiols. When compared to glutathione and glutathione disulfide, the standard redox buffer, dithiols 1-5 improved the protein folding rates but not the yields. However, dithiols 6 and 7, and the corresponding monothiol 8 increased the folding rates 8-17 times and improved the yields 15-42% at 1 mg/mL lysozyme. Moreover, aromatic dithiol 6 increased the in vitro folding yield as compared to the corresponding aromatic monothiol 8. Therefore, aromatic dithiols should be useful for protein folding, especially at high protein concentrations. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.049
• 作为产物：
  描述：

  乙酰硫酯-四聚乙二醇系列 在 氧气 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以93%的产率得到3,6,9,16,19,22-hexaoxa-12,13-dithiatetracosane-1,24-diol
  参考文献：
  名称：

  金糖纳米颗粒：模仿糖萼状表面的合成多价配体，是糖生物学研究的工具。

  摘要：

  描述了一种简单通用的方法，用于定制具有3D多价碳水化合物展示和球状形状的糖官能化金纳米团簇（糖纳米颗粒）。该方法允许制备具有生物学上显着的低聚糖以及具有不同碳水化合物密度的糖纳米颗粒。还已经制备了荧光糖纳米颗粒以在生物测试中标记细胞。该材料是水溶性的，在生理条件下稳定，并且呈现出特别小的芯尺寸。所有这些都已通过（1）NMR，UV和IR光谱，TEM和元素分析进行​​了表征。它们的高度多价网络可以模拟糖鞘脂的聚集和质膜上的相互作用，从而为糖生物学研究提供了可控的系统。此外，

  DOI：

  10.1002/chem.200204544

文献信息

• IONIC RESERVOIR AT ELECTRODE SURFACE
  申请人：AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD. Commonwealth Scientific and Industrial Research Organization

  公开号：EP0639269A1

  公开（公告）日：1995-02-22
• EP0639269A4
  申请人：——

  公开号：EP0639269A4

  公开（公告）日：1995-04-19
• ETHER POLYSULFIDES AND POLYETHER POLYSULFIDES, THEIR PREPARATION AND USE
  申请人：Cheng Yang

  公开号：US20110306531A1

  公开（公告）日：2011-12-15

  Novel sulfur-containing compositions comprise a polyether polysulfide or an ether polysulfide. The polyether polysulfide may be based upon an alkoxylate (an alcohol or glycol-initiated compound) that is a copolymer of at least two of ethylene oxide, propylene oxide and butylene oxide. The polyether polysulfide may alternatively be based upon a homopolymer of ethylene oxide, propylene oxide or butylene oxide. The ether polysulfide may be based upon a methoxy-capped polyglycol or an alkyl ether of 1,3-dichloro-2-propanol.
• US5401378A
  申请人：——

  公开号：US5401378A

  公开（公告）日：1995-03-28
• [EN] IONIC RESERVOIR AT ELECTRODE SURFACE
  申请人：AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE

  公开号：WO1992017788A1

  公开（公告）日：1992-10-15

  (EN) The present invention relates to electrode membrane combinations for use in biosensors. The membrane is attached to the electrode by means of a linker molecule in a manner such that a hydrophilic space is provided between the membrane and the electrode. The linker molecule comprises within the same molecule a hydrophobic region which constitutes at least a proportion of the amphiphilic molecules making up the membrane or is attached to or is embedded in the membrane, an attachment region attached to the electrode and a hydrophilic region intermediate said hydrophobic and attachment regions. The hydrophilic region spans the space between the membrane and the electrode.(FR) L'invention concerne des combinaisons de membranes d'électrode destinées aux biodétecteurs. La membrane est fixée à l'électrode au moyen d'une molécule de liaison, de manière qu'un espace hydrophile existe entre la membrane et l'electrode. La molécule de liaison comprend, dans la même molécule, une zone hydrophobe qui constitue au moins un pourcentage donné des molécules amphiphiliques constituant la membrane, ou est fixée à la membrane ou noyée dans celle-ci, une zone de fixation sur l'électrode et une zone hydrophile entre lesdites régions hydrophobe et de fixation. La zone hydrophile s'étend à travers l'espace entre la membrane et l'électrode.