D-lyxo-[2]hexulosonic acid methyl ester | 109214-36-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-lyxo-[2]hexulosonic acid methyl ester
• 英文别名: D-lyxo-[2]Hexulosonsaeure-methylester；methyl (3S,4S,5R)-3,4,5,6-tetrahydroxy-2-oxohexanoate
• CAS: 109214-36-0
• 化学式: C₇H₁₂O₇
• 分子量: 208.168
• InChiKey: KPHIBLNUVRGOGU-WISUUJSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  D-lyxo-[2]hexulosonic acid methyl ester 在 乙醇 、 sodium methylate 作用下， 生成 D-抗坏血酸
  参考文献：
  名称：

  Bench to Bedside Resuscitation from Prolonged Ventricular Fibrillation

  摘要：

  AbstractVentricular fibrillation (VF) remains the most common cardiac arrest heart rhythm. Defibrillation is the primary treatment and is very effective if delivered early within a few minutes of onset of VF. However, successful treatment of VF becomes increasingly more difficult when the duration of VF exceeds 4 minutes. Classically, successful cardiac arrest resuscitation has been thought of as simply achieving restoration of spontaneous circulation (ROSC). However, this traditional approach fails to consider the high early post—cardiac arrest mortality and morbidity and ignores the reperfusion injuries, which are manifest in the heart and brain. More recently, resuscitation from cardiac arrest has been divided into two phases; phase I, achieving ROSC, and phase II, treatment of reperfusion injury. The focus in both phases of resuscitation remains the heart and brain, as prolonged VF remains primarily a two‐organ disease. These two organs are most sensitive to oxygen and substrate deprivation and account for the vast majority of early post‐resuscitation mortality and morbidity. This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain.

  DOI：

  10.1111/j.1553-2712.2001.tb01155.x
• 作为产物：
  描述：

  甲醇 、 D-半乳糖酸-1,4-内酯 在 sodium chlorate 、 phosphorus pentoxide 、 vanadia 作用下， 生成 D-lyxo-[2]hexulosonic acid methyl ester
  参考文献：
  名称：

  Bench to Bedside Resuscitation from Prolonged Ventricular Fibrillation

  摘要：

  AbstractVentricular fibrillation (VF) remains the most common cardiac arrest heart rhythm. Defibrillation is the primary treatment and is very effective if delivered early within a few minutes of onset of VF. However, successful treatment of VF becomes increasingly more difficult when the duration of VF exceeds 4 minutes. Classically, successful cardiac arrest resuscitation has been thought of as simply achieving restoration of spontaneous circulation (ROSC). However, this traditional approach fails to consider the high early post—cardiac arrest mortality and morbidity and ignores the reperfusion injuries, which are manifest in the heart and brain. More recently, resuscitation from cardiac arrest has been divided into two phases; phase I, achieving ROSC, and phase II, treatment of reperfusion injury. The focus in both phases of resuscitation remains the heart and brain, as prolonged VF remains primarily a two‐organ disease. These two organs are most sensitive to oxygen and substrate deprivation and account for the vast majority of early post‐resuscitation mortality and morbidity. This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain.

  DOI：

  10.1111/j.1553-2712.2001.tb01155.x

文献信息

• Kinetics of Transformation of 2-Ketopolyhydroxy Acids
  作者：Peter P. Regna、B. P. Caldwell

  DOI：10.1021/ja01230a027

  日期：1944.2
• Asai et al., Nippon Nogeikagaku Kaishi, 1952, vol. 26, p. 625,629
  作者：Asai et al.

  DOI：——

  日期：——
• VLASSA, M.
  作者：VLASSA, M.

  DOI：——

  日期：——
• KRACHANOVA, M.;POPOVA, YA.;KOVACHEVA, E., NAUCH. TR. VISSH IN-T XRANIT. I BKYC. PROM-CT. PLOVDIV, 1984, 31, N 2, 17+
  作者：KRACHANOVA, M.、POPOVA, YA.、KOVACHEVA, E.

  DOI：——

  日期：——
• RUBTSOV, I. A.;ZOTCHIK, N. V.;MALCHENKO, O. A.;POPOVA, YA. G.;ANGELOVA, S+
  作者：RUBTSOV, I. A.、ZOTCHIK, N. V.、MALCHENKO, O. A.、POPOVA, YA. G.、ANGELOVA, S+

  DOI：——

  日期：——