[2-(4-fluorophenyl)-1H-imidazol-5-yl]methanol | 191158-31-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [2-(4-fluorophenyl)-1H-imidazol-5-yl]methanol
• CAS: 191158-31-3
• 化学式: C₁₀H₉FN₂O
• mdl: MFCD10001459
• 分子量: 192.193
• InChiKey: VSSRQWLMZUGXRC-UHFFFAOYSA-N

物化性质

• 沸点：
  429.1±30.0 °C(Predicted)
• 密度：
  1.331±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [2-(4-fluorophenyl)-1H-imidazol-5-yl]methanol 在 氯化亚砜 作用下， 反应 0.17h， 生成 5-(chloromethyl)-2-(4-fluorophenyl)-1H-imidazole
  参考文献：
  名称：

  2-Phenyl-4-(aminomethyl)imidazoles as Potential Antipsychotic Agents. Synthesis and Dopamine D2 Receptor Binding

  摘要：

  A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D-2 selective benzamide antipsychotics. The title compounds were synthesized and tested for blockade of[H-3]YM-09151 binding in cloned African green monkey dopamine D-2 receptor preparations. The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)-pyrroles.

  DOI：

  10.1021/jm00012a026
• 作为产物：
  描述：

  对氟苯腈 在 ammonium hydroxide 、 氯化铵 、 lithium hexamethyldisilazane 作用下， 以 乙醚 为溶剂， 反应 2.5h， 生成 [2-(4-fluorophenyl)-1H-imidazol-5-yl]methanol
  参考文献：
  名称：

  2-Phenyl-4-(aminomethyl)imidazoles as Potential Antipsychotic Agents. Synthesis and Dopamine D2 Receptor Binding

  摘要：

  A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D-2 selective benzamide antipsychotics. The title compounds were synthesized and tested for blockade of[H-3]YM-09151 binding in cloned African green monkey dopamine D-2 receptor preparations. The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)-pyrroles.

  DOI：

  10.1021/jm00012a026

文献信息

• [EN] HERBICIDAL IMIDAZOLE COMPOUNDS<br/>[FR] COMPOSÉS IMIDAZOLE HERBICIDES
  申请人：[en]SYNGENTA CROP PROTECTION AG

  公开号：WO2023066783A1

  公开（公告）日：2023-04-27

  The present invention relates to compounds of Formula (I) or an agronomically acceptable salt of said compounds wherein Q, R1and R2are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.