2-溴喹啉-4-甲醛 | 866831-75-6

• 物质功能分类: 医药中间体 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2-溴喹啉-4-甲醛
• 英文名称: 2-bromo-4-quinolinecarboxaldehyde
• 英文别名: 2-Bromoquinoline-4-carbaldehyde
• CAS: 866831-75-6
• 化学式: C₁₀H₆BrNO
• 分子量: 236.068
• InChiKey: LLFVQQKMECYPGQ-UHFFFAOYSA-N

物化性质

• 沸点：
  362.7±22.0 °C(Predicted)
• 密度：
  1.632±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS
  申请人：HADDACH Mustapha

  公开号：US20100331315A1

  公开（公告）日：2010-12-30

  The invention provides compounds that inhibit PIM kinases and/or CK2, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders.

  该发明提供了能够抑制PIM激酶和/或CK2的化合物以及含有这些化合物的组合物。这些化合物和组合物可用于治疗增殖性疾病如癌症，以及其他与激酶相关的疾病，包括炎症、疼痛、血管疾病、病原体感染和某些免疫性疾病。
• [EN] RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS<br/>[FR] RHODANINES ET HÉTÉROCYCLES ASSOCIÉS EN TANT QU'INHIBITEURS DE KINASE
  申请人：CYLENE PHARMACEUTICALS INC

  公开号：WO2010148351A1

  公开（公告）日：2010-12-23

  The invention provides compounds that inhibit PIM kinases and/or CK2, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders.