(S)-(-)-Blebbistatin O-Benzoate | 1217832-61-5

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-(-)-Blebbistatin O-Benzoate
• 英文别名: [(3aS)-6-methyl-4-oxo-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-3a-yl] benzoate
• CAS: 1217832-61-5
• 化学式: C₂₅H₂₀N₂O₃
• 分子量: 396.4
• InChiKey: ICIURMLAMQGRRU-RUZDIDTESA-N

物化性质

• 熔点：
  147-148°C
• 沸点：
  581.7±60.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)
• 溶解度：
  氯仿（微溶）、二氯甲烷（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHOD FOR DESTROYING CELLULAR MECHANICAL HOMEOSTASIS AND PROMOTING REGENERATION AND REPAIR OF TISSUES AND ORGANS, AND USE THEREOF
  申请人：INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES

  公开号：US20210069177A1

  公开（公告）日：2021-03-11

  Disclosed are a method for destroying cellular mechanical homeostasis and the use thereof, especially disclosed is a method for destroying cellular mechanical homeostasis by using a Myosin inhibitor thereby leading to cell softening and reduction of fibrosis in tissues and organs. Also disclosed are a method for promoting regeneration and repair of tissues and organs and the use thereof. The Myosin inhibitor can destroy the homeostasis of the cellular mechanical stress system, reduce the rigidity of tissues and organs in a pathological state, and stimulate stress and regeneration reactions similar to those in the regeneration processes in lower organisms; and can use the characteristics to greatly inhibit fibrosis during the organ damage and to promote the regeneration and repair of tissues and organs, and meanwhile can use stress response to greatly improve the ability of cellular genetic repair. The Myosin inhibitor is preferably (−)-Blebbistatin, or a derivative thereof (−)-Blebbistatin O-Benzoate. The method requires only a single small molecule or single factor treatment, and is simple in operation and good in repeatability, and can be used as a new method to stimulate stress response, to stimulate regeneration response, to improve the ability of cellular genetic repair and/or promote regeneration and repair of tissues and organs.
• CELL INDUCTION METHOD
  申请人：INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES

  公开号：US20210230550A1

  公开（公告）日：2021-07-29

  The present invention relates to a cell induction method, in particular to a method for inducing differentiation of fibroblasts into adipocytes, comprising the following steps: Cultivating the fibroblasts in a culture medium, adding a Myosin inhibitor and BMP4 to the culture medium, and continuously cultivating same until adipocytes are obtained. The present invention further relates to a method for inducing the conversion of fibroblasts into immortalized cells and use thereof. The method comprises the following steps: cultivating the fibroblasts in a culture medium, adding Myosin inhibitor to the culture medium, and continuously cultivating same until immortalized cells are obtained. The present invention further relates to a method for inducing in vitro amplification of hepatocytes. The present invention further relates to use of a Myosin inhibitor, especially (-)-Blebbistatin or (S)-(-)-Blebbistatin, O-Benzoate, and hepatocytes obtained by means of the method for inducing in vitro amplification of hepatocytes, constructing of bioartificial livers, and constructing models of liver disease.