[2]quinolyl-acetic acid amide | 2859-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [2]quinolyl-acetic acid amide
• 英文别名: [2]Chinolyl-essigsaeure-amid；2-Chinolin-acetamid；2-Chinolyl-acetamid；2-Chinolinacetamid；2-quinolin-2-ylacetamide
• CAS: 2859-22-5
• 化学式: C₁₁H₁₀N₂O
• mdl: MFCD00624870
• 分子量: 186.213
• InChiKey: WEHFQXPHQWWTGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [2]quinolyl-acetic acid amide 在 盐酸 作用下， 生成 2-(喹啉-2-基)乙酸乙酯
  参考文献：
  名称：

  制备喹啉基和吡啶基乙酸酯的新方法。

  摘要：

  DOI：

  10.1002/ardp.19572900505
• 作为产物：
  描述：

  3-Methyl-4-quinolin-2-yl-1,2-oxazol-5-amine 以75%的产率得到
  参考文献：
  名称：

  YAMANAKA H.; EGAWA H.; SAKAMOTO T., CHEM. AND PHARM. BULL., 1978, 26, NO 9, 2759-2764

  摘要：

  DOI：

文献信息

• Compounds for inhibiting KSP kinesin activity
  申请人：Tagat R. Jayaram

  公开号：US20060247320A1

  公开（公告）日：2006-11-02

  The present invention provides compounds of Formula I (wherein R 1 , R 3 , X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.

  本发明提供了I式化合物（其中R1、R3、X、W、Z和环Y的定义如本文所述）。本发明还提供了包含这些化合物的组合物，用于治疗与KSP肌动蛋白活性相关的细胞增殖性疾病或紊乱，并抑制KSP肌动蛋白活性。
• Substituted imidazolinyl nicotine acids, esters and salts and use thereof as herbicidal agents
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0041623A2

  公开（公告）日：1981-12-16

  There are provided novel 2-(2-imidazolin-2-yl)pyridine and quinoline compounds, a process and intermediate compounds forthe preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.

  本文提供了新型 2-(2-咪唑啉-2-基)吡啶和喹啉化合物、其制备工艺和中间体化合物，以及用其控制多种一年生和多年生植物物种的方法。
• Method to beneficially influence & alter the development & life cycle of agronomic and horticultural crops with certain imidazolinyl nicotinic acids and derivatives thereof
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0041624A2

  公开（公告）日：1981-12-16

  There is provided a method for increasing axillary branching, tillering, flowering, and yield of agronomic and horticultural crops, by applying to said crop plants or to soil containing the seeds or other propagating organs of said plants, an effective amount of a 2-(2-imidazolin-2-yl)pyridine or 2-(2-imidazolin-2-yl)quinoline derivative.

  本发明提供了一种增加农艺和园艺作物腋枝、分蘖、开花和产量的方法，该方法是将有效量的 2-(2-咪唑啉-2-基)吡啶或 2-(2-咪唑啉-2-基)喹啉衍生物施用于所述作物植株或含有所述植株种子或其他繁殖器官的土壤中。
• Thiazolo [f]-fused hexahydroquinoline derivatives as dopaminergic agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0260642A2

  公开（公告）日：1988-03-23

  Hetero [f] fused carbocyclic pyridines of the formula I are described, as well as processes for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

  描述了式 I 的杂[f]融合碳环吡啶及其制备工艺和药物组合物。 描述了其作为多巴胺激动剂对突触前多巴胺受体具有选择性的作用，可用作多巴胺能药、抗精神病药和抗高血压药以及治疗高泌乳素血症相关疾病和中枢神经系统疾病。
• Aryl–indolyl maleimides as inhibitors of CaMKIIδ. Part 1: SAR of the aryl region
  作者：Daniel E. Levy、Dan-Xiong Wang、Qing Lu、Zheng Chen、John Perumattam、Yong-jin Xu、Albert Liclican、Jeffrey Higaki、Hanmin Dong、Maureen Laney、Babu Mavunkel、Sundeep Dugar

  DOI：10.1016/j.bmcl.2008.02.059

  日期：2008.4

  A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin dependant kinase. Inhibitory activities against the enzyme ranged from 34 nM to > 20 mu M and were dependant upon both the nature of the aryl group and the hydrogen bond donating potential of the maleimide ring. Key interactions with the kinase ATP site and hinge region were found to be consistent with homology modeling predictions. (C) 2008 Elsevier Ltd. All rights reserved.