2-甲氧基-3-甲基丁-2-烯 | 26578-81-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-甲氧基-3-甲基丁-2-烯
• 英文名称: 3-Methoxy-2-methyl-2-butene
• 英文别名: 2-methoxy-3-methylbut-2-ene；2-Methoxy-3-methylbuten-2；2-Methoxy-3-methyl-but-2-en；3-Methoxy-3-methyl-2-buten；2-Butene, 2-methoxy-3-methyl-
• CAS: 26578-81-4
• 化学式: C₆H₁₂O
• 分子量: 100.161
• InChiKey: QFVDGBFHOZBSII-UHFFFAOYSA-N

物化性质

• 熔点：
  120 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• 沸点：
  97 °C
• 密度：
  0.787±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-甲氧基-3-甲基丁-2-烯 在 potassium tert-butylate 、 甲基锂 作用下， 以 甲醇 、 四氯化碳 、 乙醚 、 正戊烷 为溶剂， 反应 8.0h， 生成 4-methyl-3-penten-2-one (2,4-dinitrophenyl)hydrazone
  参考文献：
  名称：

  Hamon, David P. G.; Trenerry, Craige V., Australian Journal of Chemistry, 1980, vol. 33, # 4, p. 809 - 821

  摘要：

  DOI：
• 作为产物：
  描述：

  3-methoxy-3,4,4-trimethyloxetan-2-one 在 potassium carbonate 作用下， 以65%的产率得到2-甲氧基-3-甲基丁-2-烯
  参考文献：
  名称：

  Hamon, David P. G.; Trenerry, Craige V., Australian Journal of Chemistry, 1980, vol. 33, # 4, p. 809 - 821

  摘要：

  DOI：

文献信息

• DRUG DELIVERY POLYMER AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20140308234A1

  公开（公告）日：2014-10-16

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

  本文描述了基于铂的刷状臂星形聚合物（Pt-BASPs），或其药物组合物，用于传递基于铂的药剂，如顺铂。还提供了涉及Pt-BASPs，或其药物组合物，用于治疗增殖性疾病如癌症（例如肺癌、头颈癌、食道癌、胃癌、乳腺癌、胰腺癌、肝癌、肾癌或前列腺癌）的方法和试剂盒。
• CHLOROFLUOROBENZENE COMPOUND, OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE
  申请人：HASEBA YASUHIRO

  公开号：US20130085306A1

  公开（公告）日：2013-04-04

  A liquid crystal compound and a liquid crystal medium are described. The liquid crystal compound is stable to heat and light and has a large dielectric anisotropy and a large optical anisotropy. The liquid crystal medium has a wide temperature range of liquid crystal phase, a large optical anisotropy and a large dielectric anisotropy, and exhibits an optically isotropic liquid crystal phase. The liquid crystal compound has 4 or 5 benzene rings, one of which is a chlorofluorobenzene ring. The liquid crystal medium is characterized in containing the liquid crystal compound and a chiral dopant and exhibiting an optically isotropic liquid crystal phase.

  描述了一种液晶化合物和液晶介质。该液晶化合物对热和光稳定，并具有较大的介电各向异性和较大的光学各向异性。液晶介质具有宽广的液晶相温度范围，较大的光学各向异性和较大的介电各向异性，并表现出光学各向同性的液晶相。该液晶化合物具有4或5个苯环，其中一个是氯氟苯环。该液晶介质的特点是含有该液晶化合物和一个手性掺杂剂，并表现出光学各向同性的液晶相。
• OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE
  申请人：JNC CORPORATION

  公开号：US20160186060A1

  公开（公告）日：2016-06-30

  A liquid crystal composition is described, containing an achiral component T and a chiral dopant and exhibiting an optically isotropic liquid crystal phase. The achiral component T contains at least one compound represented by formula (1). In formula (1), for example, R 1 is alkyl having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkoxy having 1 to 11 carbons, ring A 1 and ring A 2 independently represent fluorinated 1,4-phenylene or unsubstituted 1,4-phenylene, Z 1 , Z 2 and Z 3 are independently a single bond, —(CH 2 ) 2 —, —COO—, —CF 2 O— or —CH═CH—, X 1 is hydrogen, halogen, —CF 3 , —OCF 3 or —C≡N, L 1 , L 2 , L 3 and L 4 are independently hydrogen or halogen, and i is 0 or 1.

  描述了一种液晶组合物，包含一个无手性成分T和一个手性掺杂剂，并展示出光学各向同性液晶相。无手性成分T至少包含一个由式（1）表示的化合物。 在式（1）中，例如，R1是具有1到12个碳的烷基，具有2到12个碳的烯基，或具有1到11个碳的烷氧基，环A1和环A2独立地表示氟代的1,4-苯撑基或未取代的1,4-苯撑基，Z1、Z2和Z3独立地表示单键，—(CH2)2—，—COO—，—CF2O—或—CH═CH—，X1是氢，卤素，—CF3，—OCF3或—C≡N，L1、L2、L3和L4独立地表示氢或卤素，i为0或1。
• LIQUID CRYSTAL COMPOUND HAVING CHLORONAPHTHALENE MOIETY, LIQUID CRYSTAL COMPOSITION, AND OPTICAL DEVICE
  申请人：HASEBA Yasuhiro

  公开号：US20090065739A1

  公开（公告）日：2009-03-12

  A compound represented by formula (1): wherein R 1 is hydrogen or alkyl having 1 to 20 carbons, in which in the alkyl, arbitrary —CH 2 — may be replaced by —O—, —S—, —COO—, —CH═CH— or —C≡C—, and arbitrary hydrogen may be replaced by halogen or alkyl having 1 to 3 carbons; ring A 1 , ring A 2 , ring A 3 , ring A 4 and ring A 5 are each independently a benzene ring, a piperidine ring, a tetrahydropyrane ring or a dioxane ring, in which in the rings, arbitrary hydrogen may be replaced by halogen, alkyl having 1 to 3 carbons, alkoxy having 1 to 3 carbons or halogenated alkyl having 1 to 3 carbons, and —CH═ may be replaced by —N═; Z 1 , Z 2 , Z 4 , Z 5 and Z 6 are each independently a single bond, —COO— or —CF 2 O—; Z 3 is a single bond or —CF 2 O—, and in the case where Z 3 is a single bond, ring A 3 is a ring represented by formula (RG-5), or L 1 and L 2 are both fluorine, or at least one of Z 1 , Z 2 , Z 4 , Z 5 and Z 6 is —CF 2 O—; L 1 , L 2 , L 3 and L 4 are each independently hydrogen or halogen; X 1 is hydrogen, halogen, —C≡N, —N═C═S, —C≡C—C≡N, —SF 5 or alkyl having 1 to 10 carbons, in which in the alkyl, arbitrary —CH 2 — may be replaced by —O—, —S—, —CH═CH— or —C≡C—, and arbitrary hydrogen may be replaced by halogen; and 1, m, n, o and p are each independently 0 or 1, provided that l+m+n+o+p≦4:

  化合物的化学式为(1):其中R1是氢原子或具有1至20个碳的烷基，其中在烷基中，任意的—CH2—可以被—O—，—S—，—COO—，—CH═CH—或—C≡C—所取代，并且任意的氢可以被卤素或具有1至3个碳的烷基所取代；环A1，环A2，环A3，环A4和环A5分别独立地是苯环，哌啶环，四氢吡喃环或二噁烷环，在环中，任意的氢可以被卤素，具有1至3个碳的烷基，具有1至3个碳的烷氧基或卤代的具有1至3个碳的烷基所取代，而—CH═可以被—N═所取代；Z1，Z2，Z4，Z5和Z6分别独立地是单键，—COO—或—CF2O—；Z3是单键或—CF2O—，在Z3为单键的情况下，环A3是由(RG-5)式所表示的环，或L1和L2都是氟原子，或Z1，Z2，Z4，Z5和Z6中至少有一个是—CF2O—;L1，L2，L3和L4分别独立地是氢原子或卤素；X1是氢原子，卤素，—C≡N，—N═C═S，—C≡C—C≡N，—SF5或具有1至10个碳的烷基，在烷基中，任意的—CH2—可以被—O—，—S—，—CH═CH—或—C≡C—所取代，并且任意的氢可以被卤素所取代；而1，m，n，o和p独立地为0或1，但要求l+m+n+o+p≦4。
• CHLOROFLUOROBENZENE COMPOUND, OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM, AND OPTICAL DEVICE
  申请人：Yasuhiro Haseba

  公开号：US20100296029A1

  公开（公告）日：2010-11-25

  A liquid crystal compound and a liquid crystal medium are described. The liquid crystal compound is stable to heat and light and has a large dielectric anisotropy and a large optical anisotropy. The liquid crystal medium has a wide temperature range of liquid crystal phase, a large optical anisotropy and a large dielectric anisotropy, and exhibits an optically isotropic liquid crystal phase. The liquid crystal compound has 4 or 5 benzene rings, one of which is a chlorofluorobenzene ring. The liquid crystal medium is characterized in containing the liquid crystal compound and a chiral dopant and exhibiting an optically isotropic liquid crystal phase.

  本文描述了一种液晶化合物和液晶介质。该液晶化合物对热和光稳定，并具有大的介电各向异性和大的光学各向异性。液晶介质具有广泛的液晶相温度范围，大的光学各向异性和大的介电各向异性，并表现出光学各向同性的液晶相。液晶化合物具有4或5个苯环，其中一个是氯氟苯环。液晶介质的特点在于含有液晶化合物和手性掺杂剂，并表现出光学各向同性的液晶相。