(R)-2-Hydroxypropanoyl chloride | 685141-32-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: (R)-2-Hydroxypropanoyl chloride
• 英文别名: (2R)-2-hydroxypropanoyl chloride
• CAS: 685141-32-6
• 化学式: C₃H₅ClO₂
• 分子量: 108.525
• InChiKey: HGVUWQBXZZWUGD-UWTATZPHSA-N

物化性质

• 沸点：
  144.5±23.0 °C(Predicted)
• 密度：
  1.285±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  色醇 、 (R)-2-Hydroxypropanoyl chloride 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以47.4 mg的产率得到(S)-2-(1H-indol-3-yl)ethyl 2-hydroxypropanoate
  参考文献：
  名称：

  Indole Derivatives from a Marine Sponge-Derived Yeast as DPPH Radical Scavengers

  摘要：

  Two new indole derivatives (3, 4) and three known compounds (1, 2, 5) were isolated as radical scavengers from the culture filtrate of a marine sponge-derived yeast. Their structures were determined to be tyrosol (1), tryptophol (2). 2-(1H-indol-3-yl)ethyl 2-hydroxypropanoate (3), 2-(1H-indol-3-yl)ethyl 5-hydroxypentanoate (4), and cyclo(L-Pro-L-Tyr) (5) on the basis of their spectroscopic data. The absolute configurations of compounds 3 and 5 were determined by chiral HPLC analysis combined with synthesis and Marfey's method, respectively. Each obtained compound was evaluated for DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, and all compounds exhibited weak activities.

  DOI：

  10.1021/np900483g
• 作为产物：
  描述：

  (R)-2-羟基丙酸 在 氯化亚砜 作用下， 反应 6.0h， 生成 (R)-2-Hydroxypropanoyl chloride
  参考文献：
  名称：

  Indole Derivatives from a Marine Sponge-Derived Yeast as DPPH Radical Scavengers

  摘要：

  Two new indole derivatives (3, 4) and three known compounds (1, 2, 5) were isolated as radical scavengers from the culture filtrate of a marine sponge-derived yeast. Their structures were determined to be tyrosol (1), tryptophol (2). 2-(1H-indol-3-yl)ethyl 2-hydroxypropanoate (3), 2-(1H-indol-3-yl)ethyl 5-hydroxypentanoate (4), and cyclo(L-Pro-L-Tyr) (5) on the basis of their spectroscopic data. The absolute configurations of compounds 3 and 5 were determined by chiral HPLC analysis combined with synthesis and Marfey's method, respectively. Each obtained compound was evaluated for DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, and all compounds exhibited weak activities.

  DOI：

  10.1021/np900483g

文献信息

• Indole Derivatives from a Marine Sponge-Derived Yeast as DPPH Radical Scavengers
  作者：Yasumasa Sugiyama、Yuki Ito、Motofumi Suzuki、Akira Hirota

  DOI：10.1021/np900483g

  日期：2009.11.30

  Two new indole derivatives (3, 4) and three known compounds (1, 2, 5) were isolated as radical scavengers from the culture filtrate of a marine sponge-derived yeast. Their structures were determined to be tyrosol (1), tryptophol (2). 2-(1H-indol-3-yl)ethyl 2-hydroxypropanoate (3), 2-(1H-indol-3-yl)ethyl 5-hydroxypentanoate (4), and cyclo(L-Pro-L-Tyr) (5) on the basis of their spectroscopic data. The absolute configurations of compounds 3 and 5 were determined by chiral HPLC analysis combined with synthesis and Marfey's method, respectively. Each obtained compound was evaluated for DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, and all compounds exhibited weak activities.