N-tert-butoxycarbonyl bis(2-thioethyl)amine | 321658-87-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tert-butoxycarbonyl bis(2-thioethyl)amine
• 英文别名: N-tert-butoxycarbonylbis(2-thioethyl)amine；tert-butyl N,N-bis(2-sulfanylethyl)carbamate
• CAS: 321658-87-1
• 化学式: C₉H₁₉NO₂S₂
• 分子量: 237.387
• InChiKey: LMTNKAMVFZCGTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  31.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-tert-butoxycarbonyl bis(2-thioethyl)amine 在 sodium carbonate 、 potassium carbonate 、 caesium carbonate 、 溶剂黄146 、 potassium iodide 、 sodium iodide 、 锌 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 、 苯 为溶剂， 反应 98.0h， 生成 Tritert-butyl 11-[4-[[4-[(2-methylpropan-2-yl)oxycarbonyl]-1,7-dithia-4,11-diazacyclotetradec-11-yl]methyl]benzoyl]-1,4,8,11-tetrazacyclotetradecane-1,4,8-tricarboxylate
  参考文献：
  名称：

  New heteroditopic, linked macrocyclic systems derived from selectively protected N2S2-, N3O2- and N4-donor macrocycles

  摘要：

  使用经过选择性叔丁氧羰基保护的1,9-二硫-5,13-二氮杂环十六烷1、1,7-二硫-4,11-二氮杂环十四烷2、1,4,8,11-四氮杂环十四烷3以及2,5-二氧-8,11,14-三氮-1,6(1,2)-二苯并环十五烷4的衍生物，实现了包括N2S2-和N4-或N3O2-供体位点组合在内的新型连结异双位点大环体系的合成。这些产物中引入两种不同类型的结合位点，使它们成为合成一系列混合金属、二核和寡核金属配合物的合适候选。

  DOI：

  10.1039/b004797j
• 作为产物：
  描述：

  N,N-双(2-氯乙基)氨基甲酸叔丁酯 在 sodium methylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.08h， 生成 N-tert-butoxycarbonyl bis(2-thioethyl)amine
  参考文献：
  名称：

  New heteroditopic, linked macrocyclic systems derived from selectively protected N2S2-, N3O2- and N4-donor macrocycles

  摘要：

  使用经过选择性叔丁氧羰基保护的1,9-二硫-5,13-二氮杂环十六烷1、1,7-二硫-4,11-二氮杂环十四烷2、1,4,8,11-四氮杂环十四烷3以及2,5-二氧-8,11,14-三氮-1,6(1,2)-二苯并环十五烷4的衍生物，实现了包括N2S2-和N4-或N3O2-供体位点组合在内的新型连结异双位点大环体系的合成。这些产物中引入两种不同类型的结合位点，使它们成为合成一系列混合金属、二核和寡核金属配合物的合适候选。

  DOI：

  10.1039/b004797j

文献信息

• Syntheses and Crystal Structures of Anthracene-Attached and Anthracene-Bridged NO₂S₂-Macrocycles as Fluoroionophores
  作者：Ji-Eun Lee、Eun-Ji Lee、Young-Jin Kang、Ki-Min Park、Shim-Sung Lee

  DOI：10.5012/bkcs.2011.32.5.1761

  日期：2011.5.20

  with metal ions as well as great structural variety, macrocyclic ligands make them ideal candidates for the receptor part in the fluoroionophores. In this regard, many efforts have been devoted to the development of new fluorescent macrocycles. In the view of the receptor part, several NO2S2 macrocycles involving L that show an affinity for Hg and bind to this cation in both an exoor endocyclic manner

  荧光化学传感器因其在许多领域的物种检测和定量方面的潜在应用而受到了相当多的关注。在他们的协议中，已通过耦合结合单元（受体部分）和信号单元来制备氟离子载体，以将结合事件（输入信号）转导为可观察的输出信号。由于它们与金属离子的选择性络合以及结构多样性，大环配体使其成为氟离子载体中受体部分的理想候选者。在这方面，人们致力于开发新的荧光大环化合物。从受体部分来看，我们和另一组报道了几个涉及 L 的 NO2S2 大环，它们显示出对 Hg 的亲和力并以外环内环方式与该阳离子结合。基于这一结果，我们研究了 N-偶氮偶联类似物，它显示出 Hg 选择性；Hg 配合物的颜色也由存在的阴离子的性质控制。我们还参与了一项制备单环和连接大环的计划，该大环具有混合供体组，对重金属离子表现出高选择性。例如，我们已经报道了基于 L 和结构表征的单环和连接大环的软金属配合物的合成和结构。作为我们之前研究的延伸，我们一直对具
• A Chromo- and Fluoroionophoric Thiaoxaaza-Macrocycle Functionalized with Nitrobenzofurazan Exhibiting Mercury(II) Selectivity
  作者：Ji-Eun Lee、Shim-Sung Lee、Kyu-Seong Choi

  DOI：10.5012/bkcs.2010.31.12.3707

  日期：2010.12.20

  analytical reagent grade. NMR spectra were rec-orded on a Bruker DRX-300 spectrometer (300 MHz). Infrared spectra were measured with a Mattson Genesis Series FT-IR spectrophotometer. The mass spectra were obtained on a JEOL JMS-700 spectrometer at the Central Instrument Facility of Gyeongsang National University. The melting points were de-termined on a Electrothermal IA-9200 laboratory device and were

  包括溶剂在内的所有商业试剂均为分析试剂级。在 Bruker DRX-300 光谱仪 (300 MHz) 上记录 NMR 光谱。用 Mattson Genesis 系列 FT-IR 分光光度计测量红外光谱。质谱是在庆尚国立大学中央仪器设施的 JEOL JMS-700 光谱仪上获得的。熔点是在 Electrothermal IA-9200 实验室设备上测定的，未经校正。
• Luminescent metalloreceptors with pendant macrocyclic ionophores with NS2O3 donor sites: Synthesis, characterization and ion-binding property
  作者：Vinod P. Boricha、Subrata Patra、Sanjay Parihar、Yogendra S. Chouhan、Parimal Paul

  DOI：10.1016/j.poly.2012.06.024

  日期：2012.8

  Three new luminescent metalloreceptors have been synthesized, incorporating the Ru(II)-bipyridine moiety as a fluorogenic unit and a six membered macrocyclic moiety containing NS2O3 donor atoms as ionophores. The sulfur donor atoms have been incorporated to enhance the complexing ability of the ionophore towards heavy metal ions, although for comparison, an ionophore having NO5 donor sites has also been used. The ion-binding property of these fluoroionophores has been investigated with a large number of cations and anions, and the recognition event is monitored by fluorescence and NMR spectroscopy. The luminescence intensity is strongly quenched in the presence of Cu2+ and Fe3+ for 1; Cu2+, Fe3+, Hg2+ and Pb2+ for 2 and with Cu2+ for 3, indicating strong complexation of these metal ions with the ionophore. The fluoroionophore 2 also exhibited strong interactions with the anions F-, H2PO4- and I-. A H-1 NMR study was carried out to get information about the binding site of the ions with the ionophores. Binding constants (K-s) and the composition of the complexes formed for all the three fluoroionophores with strongly interacting ions have been determined from emission titration data. The K-s values for the metal ions are in the range 3.19 x 10(2)-8.86 x 10(3) M-1 and for anions they are in the range 8.89 x 10(2)-5.33 x 10(3) M-1. The ion-selectivity and energy transfer involved in quenching process have been discussed. (C) 2012 Elsevier Ltd. All rights reserved.
• Extra Large Macrocycle: 40-Membered Macrocycle via 2:2 Cyclization and Its Dimercury(II) Complex
  作者：Daram Jung、Rie Chamura、Yoichi Habata、Shim Sung Lee

  DOI：10.1021/ic2009607

  日期：2011.9.5

  A large 40-membered N(4)O(4)S(4) macrocyde (L(2)) was obtained through a 2:2 cyclization of the corresponding dithiol and dichloride as a minor product during the preparation of a 20-membered N(2)O(2)S(2) macrocycle (L(1), 1:1 cyclization product). Each macrocyde was successfully separated from the mixed products and identified. The larger macrocyde L(2) allowed the preparation of its dimercury(I) complex, adopting a one-dimensional (1D) stairway-like polymeric chain linked with the anion. A monomercury(II) complex of the smaller macrocyde L(1) was also prepared. Both complexes and the larger macrocyde L(2) were structurally characterized by the single crystal X-ray analysis.
• Mono- and Bis-Type NS₂-Donor Macrocyclic Fluoroionophores Exhibiting Mercury(II)-Selectivity
  作者：Sun-Hong Park、Chul-Soon Park、Seul-Gi Lee、Shim-Sung Lee

  DOI：10.5012/bkcs.2011.32.11.4117

  日期：2011.11.20