2-(4-morpholinophenyl)-2-phenyl-5-methoxycarbonyl-6-hydroxy-2H-naphtho[1,2-b]pyran | 194940-94-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(4-morpholinophenyl)-2-phenyl-5-methoxycarbonyl-6-hydroxy-2H-naphtho[1,2-b]pyran
• 英文别名: Methyl 6-hydroxy-2-(4-morpholin-4-ylphenyl)-2-phenylbenzo[h]chromene-5-carboxylate
• CAS: 194940-94-8
• 化学式: C₃₁H₂₇NO₅
• 分子量: 493.559
• InChiKey: ZEVMGWMPCMZMDH-UHFFFAOYSA-N

物化性质

• 沸点：
  704.1±60.0 °C(Predicted)
• 密度：
  1.294±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  68.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4-morpholinophenyl)-2-phenyl-5-methoxycarbonyl-6-hydroxy-2H-naphtho[1,2-b]pyran 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 2-(4-morpholinophenyl)-2-phenyl-5-methoxycarbonyl-6-methoxy-2H-naphtho[1,2-b]pyran
  参考文献：
  名称：

  SUBSTITUTED NAPHTHOPYRANS

  摘要：

  公开号：

  EP1000025B1
• 作为产物：
  描述：

  1-苯基-1-(4-吗啉-4-基)苯基-丙-2-炔-1-醇 、 1,4-二羟基-2-萘甲酸甲酯 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 2-(4-morpholinophenyl)-2-phenyl-5-methoxycarbonyl-6-hydroxy-2H-naphtho[1,2-b]pyran
  参考文献：
  名称：

  SUBSTITUTED NAPHTHOPYRANS

  摘要：

  公开号：

  EP1000025B1

文献信息

• 置換ナフトピラン類
  申请人：トランジションズ・オプティカル・インコーポレイテッド

  公开号：JP2010001297A

  公开（公告）日：2010-01-07

  【課題】新規な光発色性[光互変性（フォトクロミック）]ナフトピラン化合物並びに該ナフトピラン化合物を含有する組成物および物品の提供。【解決手段】ナフトピランのナフト部分の５−位の炭素原子およびピラン環の２−位に特定の置換基を有する化合物。例えば２−（４−モリホリノフェニル）−２−フェニル−５−メトキシカルボニル−６−ヒドロキシ−２Ｈ−ナフト［１，２−ｂ］ピラン、２−（９−エチルカルバゾール−２−イル）−２−フェニル−５−メトキシカルボニル−６−アセトキシ−２Ｈ−ナフト［１，２−ｂ］ピラン等が挙げられる。該化合物を含有する有機ホスト材料または該化合物で被覆された有機ホスト材料。さらに、このような新規なナフトピラン化合物または該ナフトピラン化合物と相補的光発色性化合物（例えば、スピロ（インドリン）型化合物等）との混合物を配合した物品、例えば、眼科用レンズおよびその他のプラスチック製透明物品。【選択図】なし

  问题是提供新型光致变色[photochromic]萘化合物以及含有该萘化合物的组合物和物品。解决方案：在萘并吡喃萘部分的 5 位碳原子和吡喃环的 2 位具有特定取代基的化合物。例如，2-(4-多叶酚苯基)-2-苯基-5-甲氧基羰基-6-hydroxy-2H-naphtho[1,2-b]pyran, 2-(9-ethylcarbazol-2-2-苯基-5-甲氧基羰基-6-乙酰氧基-2H-萘并[1,2-b]吡喃等。含有此类化合物的有机主材料或涂有此类化合物的有机主材料。此外，含有此类新型萘并吡喃化合物或此类萘并吡喃化合物与互补光色素化合物（如螺（吲哚啉）类化合物等）混合物的物品，如眼科镜片和其他塑料透明物品。无。
• EP1000025A4
  申请人：——

  公开号：EP1000025A4

  公开（公告）日：2002-10-09
• PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS
  申请人：Alcon Inc.

  公开号：US20210284806A1

  公开（公告）日：2021-09-16

  The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.
• METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES
  申请人：Alcon Inc.

  公开号：US20210371731A1

  公开（公告）日：2021-12-02

  Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).
• METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES
  申请人：Alcon Inc.

  公开号：US20220281193A1

  公开（公告）日：2022-09-08

  Described herein is a method for producing a contact lens comprising a central zone that has a diameter of about 13 mm or less, is concentric with the central axis of the contact lens, and possesses at least one photo functionality. The method comprises: applying a first polymerizable fluid composition containing at least one photochemically functional compound on a central portion of the molding surface of a female mold half to form a circular layer; partially curing, in situ, the circular layer in the female mold half; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the the molding surfaces of the female mold half and a male mold half.