2-cyclopropyl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}quinoline | 689291-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-cyclopropyl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}quinoline
• 英文别名: (R)-2-cyclopropyl-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline；2-cyclopropyl-6-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]quinoline
• CAS: 689291-94-9
• 化学式: C₁₉H₂₄N₂
• 分子量: 280.413
• InChiKey: HRMBWUJLMDNIED-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-amino-5-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}benzaldehyde 、 环丙甲基酮 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 2-cyclopropyl-6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}quinoline
  参考文献：
  名称：

  In vitro studies on a class of quinoline containing histamine H3 antagonists

  摘要：

  A series of quinoline containing histamine H-3 antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.045

文献信息

• Bicyclic-substituted amines as histamine-3 receptor ligands
  申请人：——

  公开号：US20040092521A1

  公开（公告）日：2004-05-13

  Compounds of formula (I) 1 are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.

  式（I）的化合物在治疗由组胺-3受体配体预防或改善的病症或紊乱方面是有用的。还公开了包括组胺-3受体配体的药物组合物以及使用这类化合物和组合物的方法。
• [EN] BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS<br/>[FR] AMINES BICYCLIQUES SUBSTITUEES UTILISEES COMME LIGANDS DES RECEPTEURS DE L'HISTAMINE-3
  申请人：ABBOTT LAB

  公开号：WO2004043458A1

  公开（公告）日：2004-05-27

  Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

  公式（I）的化合物在治疗由组胺-3受体配体预防或缓解的疾病或疾病中非常有用。此外，还披露了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法以及制备公式（I）范围内的化合物的过程。
• BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS
  申请人：Altenbach Robert J.

  公开号：US20090054420A1

  公开（公告）日：2009-02-26

  Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

  公式(I)的化合物可用于治疗由组胺-3受体配体预防或改善的情况或疾病。还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备公式(I)范围内化合物的过程。
• JP2006514926A
  申请人：——

  公开号：JP2006514926A

  公开（公告）日：2006-05-18
• US7153889B2
  申请人：——

  公开号：US7153889B2

  公开（公告）日：2006-12-26