1-tert-Butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | 1026156-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-tert-Butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
• 英文别名: Ethyl 1-tert-butyl-7-[4-(4-methoxyphenyl)piperazin-1-yl]-6-nitro-4-oxoquinoline-3-carboxylate
• CAS: 1026156-23-9
• 化学式: C₂₇H₃₂N₄O₆
• 分子量: 508.574
• InChiKey: ZCVDZOJEVLWJHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1-tert-Butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 在 镍 氢气 作用下， 以 乙二醇甲醚 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、207.73 kPa 条件下， 反应 4.0h， 生成 6-Amino-1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  6-Aminoquinolones as New Potential Anti-HIV Agents

  摘要：

  A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human lymphoblastoid cell lines. The 12a EC50 value was 0.1 mu M, a 7-20-fold lower concentration relative to that for compounds 8a and 7a containing a cyclopropyl and tert-butyl substituent at the N-1 position, respectively. When the C-6 amino group was replaced with a fluorine atom, a decreased antiviral effect was observed. The observed effects are selective, since potency is substantially reduced when testing the compounds against the herpes simplex virus type 1 (HSV-1). Active quinolone derivatives very efficiently interact with TAR RNA, which suggests a nucleic acid-targeted mechanism of action.

  DOI：

  10.1021/jm9903390
• 作为产物：
  描述：

  1-(4-甲氧基苯基)哌嗪 、 ethyl 1-(t-butyl)-7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 1-tert-Butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  6-Aminoquinolones as New Potential Anti-HIV Agents

  摘要：

  A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human lymphoblastoid cell lines. The 12a EC50 value was 0.1 mu M, a 7-20-fold lower concentration relative to that for compounds 8a and 7a containing a cyclopropyl and tert-butyl substituent at the N-1 position, respectively. When the C-6 amino group was replaced with a fluorine atom, a decreased antiviral effect was observed. The observed effects are selective, since potency is substantially reduced when testing the compounds against the herpes simplex virus type 1 (HSV-1). Active quinolone derivatives very efficiently interact with TAR RNA, which suggests a nucleic acid-targeted mechanism of action.

  DOI：

  10.1021/jm9903390

文献信息

• 6-Aminoquinolones as New Potential Anti-HIV Agents
  作者：Violetta Cecchetti、Cristina Parolin、Stefano Moro、Teresa Pecere、Enrica Filipponi、Arianna Calistri、Oriana Tabarrini、Barbara Gatto、Manlio Palumbo、Arnaldo Fravolini、Giorgio Palu’

  DOI：10.1021/jm9903390

  日期：2000.10.1

  A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human lymphoblastoid cell lines. The 12a EC50 value was 0.1 mu M, a 7-20-fold lower concentration relative to that for compounds 8a and 7a containing a cyclopropyl and tert-butyl substituent at the N-1 position, respectively. When the C-6 amino group was replaced with a fluorine atom, a decreased antiviral effect was observed. The observed effects are selective, since potency is substantially reduced when testing the compounds against the herpes simplex virus type 1 (HSV-1). Active quinolone derivatives very efficiently interact with TAR RNA, which suggests a nucleic acid-targeted mechanism of action.